In the past Hiroyuki Miura has collaborated on articles with Yutaka Suzuki and Young-Chul Jung. One of their most recent publications is Primary lung cancer of the middle lobe. Is its prognosis poor?. Which was published in journal Lung Cancer.

More information about Hiroyuki Miura research including statistics on their citations can be found on their Copernicus Academic profile page.

Hiroyuki Miura's Articles: (14)

Primary lung cancer of the middle lobe. Is its prognosis poor?

AbstractThe right middle lobe is unique because it is surrounded by two other lobes and the pericardium, and it is the smallest lobe. The proper surgical treatment and prognosis for cancer of the right middle lobe has not been definitively established. In order to clarify its prognosis and the best operative technique, 31 surgically treated patients with lung cancer of the right middle lobe were studied clinically and pathologically. The outcome of surgical treatment of the right middle lobe cancer was compared with other locations in the lung. The 5-year survival rate of this group was 51.5%, with a median survival time of 82.3 months. For resectable cases, the outcome for carcinomas of the middle lobe was no worse than for other locations. However the rate of exploratory thoracotomy was highest for the right middle lobe. All five patients with lobectomies are alive and disease free at 26.4–151.4 months. The 5-year survival rate of 23 bilobectomies was 40.0%, with a median survival time of 48.4 months. The difference between lobectomy and bilobectomy cases was statistically significant (P < 0.025). When the tumor was limited to the completely separated middle lobe without dissemination, pulmonary or mediastinal lymph node metastasis, lobectomy was sufficient for curative treatment.

Clinical InvestigationsSputum Cytology-Positive, Bronchoscopically Negative Adenocarcinoma of the Lung

Among a total of 114 cases of resected lung adenocarcinoma that were examined by sputum cytologic study before bronchoscopy, 17 were sputum cytology-positive, but had no abnormal bronchoscopic findings. In most of these cases, the reason for detection was sputum and bloody sputum (58.8 percent). Pathologically, many cases were classified as stage in A or more (82.4 percent) due to mediastinal lymph node metastases. More than 70 percent of the cases showed vascular invasion. The proportion of well-differentiated cases was also high (52.9 percent). The prognosis of these cases was worse than sputum cytology-negative adenocarcinoma without abnormal bronchoscopic findings and better than sputum cytology-positive adenocarcinoma with abnormal bronchoscopic findings. There was no significant difference between these cases and sputum cytology-negative adenocarcinoma with abnormal bronchoscopic findings. Combined with the bronchoscopic findings, sputum cytologic study is useful for preoperative evaluation of lymph node metastasis and prognosis. This combined approach can provide information necessary to perform sufficient dissection of mediastinal lymph nodes and proper adjuvant therapy in sputum cytology-positive adenocarcinoma cases, even though there are no abnormal bronchoscopic findings.

Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia1

AbstractThe gene encoding a transmembrane glycoprotein LIG-1, of which the extracellular region was organized with the leucine-rich repeats and immunoglobulin-like domains, was disrupted in mice by gene targeting. LIG-1-deficient mice developed a skin change on the tail and facial area after birth. The affected skin was histologically reminiscent of the epidermis in human common skin disease ‘psoriasis’. LIG-1 was expressed in basal cells of the epidermis and outer root sheath cells of hair follicles in mice. Interestingly, the LIG-1 expression was apparently down-regulated in the psoriatic lesions, suggesting that LIG-1 inversely correlates with proliferative ability of epidermal keratinocytes.

Improvement of the surface morphology of the epitaxial γ-Al2O3 films on Si(1 1 1) grown using template growth with different temperatures by Al solid and N2O gas source molecular beam epitaxy (MBE)

AbstractWe have investigated the crystalline quality and surface morphology of γ-Al2O3 films to make clear growth mode of Al2O3 grown by Al solid and N2O gas source MBE, and proposed a template growth method with different growth temperatures. The single-crystalline epitaxial Al2O3 layers were successfully grown at growth temperatures between 650 and 900°C. However, at the higher temperatures above 800°C, the surface morphology of films was very rough because of the etching of Si substrates by N2O gas in the initial growth stage of Al2O3 growth. The Al2O3 films grown at low temperatures below 650°C were polycrystalline due to SiO2 formed in the initial growth stage. The Al2O3 films grown with a template growth method have a lower values of RMS than that of Al2O3 films grown by usual growth method for same film thickness.

Petrogenesis of ferromanganese nodules from east of the Chagos Archipelago, Central Indian Basin, Indian Ocean

AbstractDeep-sea ferromanganese nodules occur over a large area and on many different sediment types of the Central Indian Basin, Indian Ocean. Selected samples were studied to determine their chemical and mineralogical compositions and microstructural features. Repeated laminations of variable thickness, alternately dominated by todorokite and vernadite, are characteristic of these nodules. These laminae show, on electron microprobe line scans, corresponding interlaminar partitioning of Mn–Cu–Ni and Fe–Co. The bulk chemical compositions of these nodules plot in both the hydrogenetic and early diagenetic fields on the Fe–Mn–(Ni + Cu + Co) ×10 ternary diagram. The binary diagram depicting the covariation of Mn + Ni + Cu against Fe + Co shows two distinct parallel regression lines, one delineated by nodules from terrigenous, siliceous ooze and siliceous ooze–terrigenous sediments and the other by nodules from red clay, siliceous ooze–red clay and calcareous ooze–red clay. An increasing diagenetic influence in the nodules with the nature of the host sediment types was observed in the sequence: terrigenous → siliceous ooze and red clay → siliceous/calcareous ooze–red clay. A negative correlation between Mn/Fe ratio and Co and a positive correlation between Mn/Fe ratio and (Ni + Cu) was established. The nodules show dendritic, laminated, and globular microstructures formed by primary growth of Fe–Mn oxide laminae. Depositional hiatuses in the primary microstructures indicate that the growth of these nodules was episodic. The oxide laminations show extremely complex growth patterns. Scattered biogenic remains and mineral grains acted as accessory `seeds' for growth of oxide layers in addition to the main nuclei. None of the primary microstructures can be uniquely linked to a particular growth process or growth rate. Radial cracks, cutting across primary microstructures, are often filled by todorokite of a later generation. Post-depositional modifications of the nodules were largely controlled by accreted biogenic remains as indicated by their progressive dissolution with increasing depth from nodule surfaces, their pseudomorphic replacement by todorokite and the later growth of phillipsite and todorokite in the microfossil molds. The growth patterns of the in-filled oxides are often controlled entirely by the cavity-walls and are discordant with the primary growth fabric. Primary todorokite was recrystallized to coarser grains of different chemical composition. Later generation veins of todorokite cut across and chaotically disrupted primary laminae.

Relationship between ceramic primer and ceramic surface pH on the bonding of dual-cure resin cement to ceramic

AbstractObjectives. This study examined the relationship between a ceramic primer and ceramic surface pH on the microtensile bond strength of dual-cure resin cement to ceramic.Methods. Ceramic blocks (Vita Celay Blanks) were cut into multiple 3 mm-thick slices and polished using 600-grit SiC paper. Two pairs were left untreated (controls), six pairs were treated with 40% phosphoric acid (PA), six pairs were treated with 20% hydrofluoric acid (HFA), and rinsed with water for either 15, 30 or 60 s. Half the specimens were silanated with Tokuso ceramics primer (TCP) (Tokuyama) and the other half with TCP formulated without phosphate monomer (TCP-NoPM). All the pairs were bonded with Bistite II dual-cure resin cement (Tokuyama) and light-cured. After 24 h water storage at 37 °C, the bonded specimens were cut into 6×0.7×0.7 mm3 beams and their microtensile bond strengths (μTBS) determined. Failure modes were determined using a confocal laser-scanning microscope. For scanning chemical analysis, the polished slices were cut into quarters, divided into seven groups of six, and treated in a similar manner as described for the μTBS test. Surface pH was then determined using a scanning chemical microscope. For SEM examination, one ceramic quarter from each of the seven groups was used.Results. Three-way ANOVA revealed that the μTBS of TCP was significantly higher than TCP-NoPM with no acidic treatment (p<0.05). However, after treatment of the ceramic surface with either PA or HFA, and 15 s rinsing, there was a significant reduction in surface pH (p<0.05), and no significant difference in μTBS between TCP and TCP-NoPM (p>0.05). For TCP, there were no significant differences in μTBS and failure mode between the control, PA, and HFA treated groups when the water rinsing time was increased. Whereas, for TCP-NoPM and surface treatment with PA, an increase in rinsing time resulted in a significant reduction in μTBS and a significant increase in surface pH (p<0.05).Significance. Acidic treatment of the ceramic surface did not significantly increase dual-cure resin/ceramic bond strengths when the ceramic primer, TCP, was used. It is suggested that when no phosphate monomer is present in a ceramic primer, dual-cure resin cement/ceramic bond strength is dependent upon the concentration of H+ ions on the ceramic surface.

Earthquake damage estimation in Metro Manila, Philippines based on seismic performance of buildings evaluated by local experts’ judgments

AbstractBuilding damage due to a scenario earthquake in Metro Manila, Philippines is estimated based on seismic performance of the buildings evaluated by local experts’ judgments. For the damage estimation, building capacity curves and fragility curve are developed from questionnaire to the local experts of structural engineering. The Delphi method is used to integrate the experts’ opinions. The derived capacity curves are validated by comparing with the result of pushover analysis for typical buildings. Building responses due to simulated ground motions are estimated by the capacity spectrum method. Damage ratios are calculated from the fragility curves and the building responses. Distributions of the damaged buildings are computed by multiplying the damage ratios and the building inventory. The distribution and the amount of the damaged buildings in this study show significant difference from the estimation with the capacity curves of HAZUS, suggesting the importance of evaluation of the region-specific building performance.

Proteolytic cleavage and cellular toxicity of the human α1A calcium channel in spinocerebellar ataxia type 6

AbstractSpinocerebellar ataxia type 6 (SCA6) is a neurodegenerative disease caused by small CAG repeat expansion in the α1A calcium channel gene. We found that the human α1A calcium channel protein expressed in human embryonic kidney 293T cells produces a 75 kDa C-terminal fragment. This fragment is more toxic to cells than the full-length α1A calcium channel, regardless of polyglutamine tract length. In cells stably transfected with plasmids of full-length α1A calcium channel cDNAs, the C-terminal fragment protein is present in the mutant transformant but not in the wild-type one, indicative that this C-terminal fragment with the expanded polyglutamine tract is more resistant to proteolysis than that with the normal sized polyglutamine tract. We speculate that the toxic C-terminal fragment, in which resistance to proteolysis is rendered by the expanded polyglutamine, has a key role in the pathological mechanism of SCA6.

Meningiomas with brain edema: Radiological characteristics on MRI and review of the literature

AbstractObject: Despite their benign characteristics, meningiomas are often accompanied by perifocal brain edema. The aims of this study are to determine what kind of characteristics on magnetic resonance (MR) image are indicative of a meningioma that produces brain edema and to investigate the mechanism responsible for brain edema accompanying meningiomas. Methods: Fifty-one patients with meningioma were examined by magnetic resonance imaging (MRI), and tumor size, tumor location, shape of tumor margin, peritumoral rim, and signal intensity of tumor on T2-weighted image (T2WI) were compared and correlated with the presence versus absence of brain edema. Surgical histopathology was also examined and correlated with the MRI findings and brain edema. Results: Shape of tumor margin, peritumoral rim, and signal intensity of tumor on T2WI correlated with brain edema on multivariate analyses. Conclusion: Invasive pattern of brain–tumor interface and hyperintensity on T2WI were indicative factors of meningiomas producing brain edema.

A new simple process for carbon coating of ceramic particles using poly(vinyl chloride)

AbstractCarbon-coated ceramic particles (Al2O3, SiO2, TiO2, MgO, CaO) were obtained by a simple mechanical mixing of these ceramic particles with poly (vinyl chloride) (PVC) powders and heating at a temperature between 600 and 1200 °C in an inert atmosphere. Carbon coating of individual particles was successfully achieved by selecting an appropriate mixing ratio between PVC powders and ceramic particles, γ-Al2O3 with high surface area having a wide range of this mixing ratio for coating. The carbon layers coated on the ceramic particles seemed to adhere tightly, but were pervious to air.

Research paperInfluence of dexamethasone on masseter muscle wet weight in growing rats

AbstractThe objective of this study was to investigate the influence of corticosteroids on the masseter wet weight and changes after discontinuation of the administration by comparison with those of hind leg skeletal muscles. Thirty-five male Wister rats, 9 weeks old, were used for the experiment. As a corticosteroids, dexamethasone was administered in drinking water for 14 days in consentrations 0.5 and 3.0 μg/ml administration groups: LD (Low Dose group) and HD (High Dose group), respectively. A 21-day recovery period was set after the discontinuation. Recovery groups: LD-r and HD-r. Non-treated groups: CO (CO-b, CO, CO-r). After the experimental period, the superficial masseter and the rectus femoris and gastrocnemius were excised, and the wet weights were measured. The wet weights of each muscle were significantly lower in the LD and HD than in the CO (p < 0.05). More significant wet weight losses of hind leg were noted in the HD (p < 0.05). The wet weight reduction rates of the rectus femoris and gastrocnemius relative to those in the CO were 50 and 44% in the HD, but that of the masseter was only 25%. The reductions recovered to weights similar to those in the CO-r after the discontinuation in the LD-r, but the weights in the HD-r were significantly lower than those in the other 2 groups (p < 0.05). Dexamethasone reduced the wet weight of the superficial masseter in the growing rats, but the influence was smaller than that on the hind leg muscles, suggesting that the reduction can be recovered by discontinuation when the corticosteroids is not administered at high doses.

Research paperBond strength of an orthodontic bonding material and adhesion energy of artificial saliva to an experimental titanium bracket

AbstractIn this study, to evaluate whether bond strength of an experimentally produced titanium bracket is sufficient for clinical application, we examined the tensile bond strength of the bracket to bovine teeth comparing with stainless steel bracket. We examined the adhesion energy of artificial saliva containing mucin, which is the major component of pellicles, to this bracket, stainless steel and plastic brackets. As a result, there was no significant difference in the tensile bond strength between the titanium and stainless steel brackets. The adhesion energy of mucin-containing artificial saliva to the titanium and stainless steel brackets was slightly lower than that to the plastic bracket. These results suggested that the experimental titanium bracket had a clinically sufficient bond strength, and pellicle formation on this bracket was lower than that on the plastic bracket.

Preliminary noteTauroursodeoxycholate and taurochenodeoxycholate stabilize bile lipid metastability through different mechanisms: relation to phospholipid fatty acid composition1

AbstractLecithin–cholesterol vesicles are present in bile and play a role in cholesterol metastability. Cholesterol holding capacity of vesicles is regulated by lecithin hydrophobicity. In the present study, the effect of therapeutic bile salts on biliary lipid secretion rate and phospholipid fatty acid composition was evaluated in bile duct-fistula rats to determine whether bile salts modulate biliary phospholipid species to, thereby, regulate a physico-chemical metastability of bile cholesterol. Rats were depleted with bile salt pool by overnight biliary diversion and reinfused intravenously with sodium taurocholate (TC) at a constant rate (200 nmol/min per 100 g b.w.) for 3 h, followed by infusion of either sodium taurochenodeoxycholate (TCDC) or tauroursodeoxycholate (TUDC) at a compatible rate. TCDC-infusion increased the biliary secretion rate of cholesterol and phospholipids with a decrease in molar ratio of cholesterol to phospholipid (C/P) when compared to values under TC-infusion, and this was associated with an increase in the molar ratio of phospholipid saturated to unsaturated fatty acids (S/U). In contrast, TUDC-infusion decreased such a biliary lipid secretion rate with an increase in C/P, and this was associated with a decrease in a molar ratio of arachidonate in phospholipids. These findings indicate that TCDC enhances a cholesterol packing density of biliary particulate species by decreasing C/P ratio and increasing S/U, whereas TUDC improves bile lithogenecity by decreasing biliary cholesterol and phospholipid secretion rates and reducing bile arachidonyl phospholipids.

Original articleBiomechanical behavior of adhesive cement layer and periodontal tissues on the restored teeth with zirconia RBFDPs using three-kinds of framework design: 3D FEA study

AbstractPurposeTo investigate stress and strain concentrations on resin-bonded fixed dental prostheses (RBFDPs) frameworks of different design using finite element analysis.MethodsA human dry skull was scanned and models were produced using three-dimensional printer. After abutment preparation, three frameworks, including a three-unit RBFDP, and two-unit cantilevered RBFDPs using #21 and #23 for the abutment tooth, were fabricated. Scanned data were subtracted to define boundary of each structure. Occlusal force (200 N) was loaded at 45° to long axis of the pontic. The distributions of shear stress and principal strain in the RBFDP models were measured to evaluate the risk for framework-debonding from the abutment teeth and the impact on periodontal tissue.ResultsThe percentage voxels with shear stress >11 MPa in adhesive cement layer of three-unit RBFDP using #21 and #23 were 4.16% and 2.25%, respectively; in two-unit cantilevered RBFDPs, it was 19.25% using #21, and 23.4% using #23. The maximum principal strain on periodontal ligaments in two-unit cantilevered RBFDPs using #21 was the largest, and smallest in the three-unit RBFDP. The maximum principal strain in framework was largest in the two-unit cantilevered RBFDP using #23, and smallest in the three-unit RBFDP.ConclusionsThe risk for framework-debonding in three-unit RBFDPs was substantially lower than that in two-unit RBFDPs. In difficult cases with indication for three-unit RBFDPs, two-unit cantilever design using the canine would be more advantageous for preservation of periodontal tissue, while for risk of framework-debonding, the design using the central incisor would be more advantageous.

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