One of their most recent publications is Abstracts of online articleInterindividual differences in circadian rhythmicity and sleep homeostasis in older people: effect of a PER3 polymorphism. Which was published in journal Neurobiology of Aging.

More information about Antoine U. Viola research including statistics on their citations can be found on their Copernicus Academic profile page.

Antoine U. Viola's Articles: (4)

Abstracts of online articleInterindividual differences in circadian rhythmicity and sleep homeostasis in older people: effect of a PER3 polymorphism

AbstractAging is associated with marked changes in the timing, consolidation and structure of sleep. Older people wake up frequently, get up earlier and have less slow wave sleep than young people, although the extent of these age-related changes differs considerably between individuals. Interindividual differences in homeostatic sleep regulation in young volunteers are associated with the variable-number, tandem-repeat (VNTR) polymorphism (rs57875989) in the coding region of the circadian clock gene PERIOD3 (PER3). However, predictors of these interindividual differences have yet to be identified in older people. Sleep electroencephalographic (EEG) characteristics and circadian rhythms were assessed in 26 healthy older volunteers (55–75 years) selected on the basis of homozygosity for either the long or short allele of the PER3 polymorphism. Homozygosity for the longer allele (PER35/5) associated with a phase-advance in the circadian melatonin profile and an earlier occurrence of the melatonin peak within the sleep episode. Furthermore, older PER35/5 participants accumulated more nocturnal wakefulness, had increased EEG frontal delta activity (0.75–1.50 Hz), and decreased EEG frontal sigma activity (11–13 Hz) during non-rapid eye movement (REM) sleep compared with PER34/4 participants. Our results indicate that the polymorphism in the clock gene PER3 may contribute to interindividual differences in sleep and circadian physiology in older people.

ReportPER3 Polymorphism Predicts Sleep Structure and Waking Performance

SummaryCircadian rhythmicity and sleep homeostasis interact to regulate sleep-wake cycles 1, 2, 3, 4, but the genetic basis of individual differences in sleep-wake regulation remains largely unknown [5]. PERIOD genes are thought to contribute to individual differences in sleep timing by affecting circadian rhythmicity [6], but not sleep homeostasis 7, 8. We quantified the contribution of a variable-number tandem-repeat polymorphism in the coding region of the circadian clock gene PERIOD3 (PER3) 9, 10 to sleep-wake regulation in a prospective study, in which 24 healthy participants were selected only on the basis of their PER3 genotype. Homozygosity for the longer allele (PER35/5) had a considerable effect on sleep structure, including several markers of sleep homeostasis: slow-wave sleep (SWS) and electroencephalogram (EEG) slow-wave activity in non-rapid eye movement (non-REM) sleep and theta and alpha activity during wakefulness and REM sleep were all increased in PER35/5 compared to PER34/4 individuals. In addition, the decrement of cognitive performance in response to sleep loss was significantly greater in the PER35/5 individuals. By contrast, the circadian rhythms of melatonin, cortisol, and peripheral PER3 mRNA expression were not affected. The data show that this polymorphism in PER3 predicts individual differences in the sleep-loss-induced decrement in performance and that this differential susceptibility may be mediated by its effects on sleep homeostasis.

Ritanserin, a serotonin-2 receptor antagonist, improves ultradian sleep rhythmicity in young poor sleepers

AbstractObjectives: To determine the effect on sleep electroencephalographic (EEG) activity of ritanserin, a serotonin-2 (5-HT2) receptor antagonist in young poor sleepers.Methods: Eight male subjects underwent two randomized night studies after receiving either a placebo or 5 mg ritanserin administered in the morning. The overnight variations in the delta (0.5–4.0 Hz) and sigma (12.25–15.0 Hz) frequency bands were characterized using a peak analysis which provided a quantitative evaluation of the time-courses in EEG activity.Results: In subjects under ritanserin, slow wave sleep duration and the number of non-rapid eye movement (NREM)–REM sleep cycles were significantly enhanced (P<0.01). The number of peaks in delta activity occurring in the normal 80–120 min range was significantly (P<0.05) increased. Using a delta peak analysis, 4 periods containing or not a significant peak were identified in each subject. A significant increase in delta activity was observed in the areas under the averaged curves during the second and the third periods (P<0.05), while sigma activity decreased under ritanserin during the first, second and third periods (P<0.05).Conclusions: These results demonstrate that ritanserin increases delta activity, possibly by opposing the inhibitory control of 5-HT2 receptor family. It restores sleep ultradian rhythmicity and improves sleep quality in young poor sleepers.

Original ArticleDawn simulation light: a potential cardiac events protector

Highlights•Light minimizes sleep-to-wake increases in heart rate in healthy young men.•Cardiac sympatho-vagal control smoothly increased from sleep-to-wake during light.•Light exposure reduces sleep-to-wake increases in parasympathetic cardiac control.•Light acts as a potential protector for cardiac vulnerability in the morning hours.

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