In the past Roberto G. Lucchini has collaborated on articles with Yueh-Hsiu Mathilda Chiu. One of their most recent publications is Sex differences in sensitivity to prenatal and early childhood manganese exposure on neuromotor function in adolescents. Which was published in journal Environmental Research.

More information about Roberto G. Lucchini research including statistics on their citations can be found on their Copernicus Academic profile page.

Roberto G. Lucchini's Articles: (3)

Sex differences in sensitivity to prenatal and early childhood manganese exposure on neuromotor function in adolescents

Highlights•Literature on perinatal Mn exposure and motor function in adolescents is limited.•We used a novel tooth biomarker to reconstruct prenatal and childhood Mn exposure.•Sex-specific association between Mn exposure and neuromotor functions was observed.•Prenatal Mn was associated with better body stability in boys but instability in girls.

Tremor, olfactory and motor changes in Italian adolescents exposed to historical ferro-manganese emission

AbstractBackground and objectiveIncreased prevalence of Parkinsonism was observed in Valcamonica, Italy, a region impacted by ferroalloy plants emissions containing manganese and other metals for a century until 2001. The aim of this study was to assess neurobehavioral functions in adolescents from the impacted region and the reference area of Garda Lake.MethodsAdolescents age 11–14 years were recruited through the school system for neuro-behavioral testing. Metals including manganese, lead, iron, zinc, copper were measured in airborne particulate matter collected with 24-h personal samplers, and in soil, tap water, blood, urine and hair. Independent variables included parental education and socio-economic status, children's body mass index, number of siblings, parity order, smoking and drinking habits.ResultsA total of 311 subjects (49.2% females), residing in either the exposed (n = 154) or the reference (n = 157) area participated. Average airborne and soil manganese were respectively 49.5 ng/m3 (median 31.4, range 1.24–517) and 958 ppm (median 897, range 465–1729) in the impacted area, and 27.4 ng/m3 (median 24.7, range 5.3–85.9) ng/m3 and 427 ppm (median 409 range 160–734) in the reference area. Regression models showed significant impairment of motor coordination (Luria-Nebraska test, p = 0.0005), hand dexterity (Aiming Pursuit test, p = 0.0115) and odor identification (Sniffin’ task, p = 0.003) associated with soil manganese. Tremor intensity was positively associated with blood (p = 0.005) and hair (p = 0.01) manganese.ConclusionHistorical environmental exposure to manganese from ferroalloy emission reflected by the concentration in soil and the biomarkers was associated with sub-clinical deficits in olfactory and motor function among adolescents.

Torvis oculis: Occupational roots of behavioral neurotoxicology in the last two centuries and beyond

AbstractBehavioral toxicology is an important discipline of toxicology that traces its roots back to the origin of psychology. A parallel development can be traced for behavioral toxicology and psychology, in that both were focused on the mind or behavior, as distinct from neurology, that recognized the brain as the ultimate target. Ancient physicians and non-medical authors incidentally described the effects of neurotoxic agents on mood. In the last two centuries, experimental psychology, behaviorism and behavioral pharmacology further developed the observation of behavior with scientific methodology. During the Industrial Revolution exposure to neurotoxicants became widespread in the western world and the consequent “psycho-organic syndrome” was likely to affect a large part of the working population. Occupational Medicine met behavioral toxicology in the 1960s. The assessment of the effects of exposure on behavior was achieved with specific tests for motor and cognitive functions, and computer technology could be used to control and analyze behavioral experiments. The contribution of this discipline became further important in the identification of early adverse effects, also from environmental and dietary exposure. The detection of behavioral changes can precede the detection of neural changes, which makes the assessment of behavior especially suitable for risk assessment. Neurobehavioral methodology has further developed in the latest years towards a global and integrated approach to the different life stages of individuals, from early life to old age.

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