Biography:

In the past E.Roy Skinner has collaborated on articles with Colin Hay and John A.O. Besson. One of their most recent publications is The composition and concentration of umbilical cord plasma lipoproteins; their relationship to the birth weight and other clinical factors of the newborn. Which was published in journal Clinica Chimica Acta.

More information about E.Roy Skinner research including statistics on their citations can be found on their Copernicus Academic profile page.

E.Roy Skinner's Articles: (5)

The composition and concentration of umbilical cord plasma lipoproteins; their relationship to the birth weight and other clinical factors of the newborn

AbstractThe present studies confirmed that plasma obtained from individual umbilical cords contains very low density, low density and high density lipoprotein particles whose mean compositions are similar to those of the adult, though they are present in considerably lower concentrations. A fairly wide variation in both composition and concentration was found between different individuals. For full-term deliveries, a positive correlation (p < 0.01) was found between the cholesteryl ester: free cholesterol ratio of the high density lipoprotein fraction and the birth weight, suggesting differences in the distribution of the particles that constitute this lipoprotein fraction. Otherwise, no correlation was found between the composition or concentration of any lipoprotein fraction and birth weight, gestation, sex or other factor investigated. Premature newboms (30–36 weeks) had concentrations of high density lipoproteins and cholesteryl ester: free cholesterol ratios of the high density lipoprotein that were markedly high in relation to their birth weights and in the same range as full-term newborns (37–40 weeks).

Original contribution1H-NMR relaxation times and water content of red blood cells from chronic alcoholic patients during withdrawal

AbstractRed blood cell proton nmr, T1 and T2 times, and water content were measured for normal control subjects and thirteen patients with chronic alcoholism during the withdrawal phase. T1 and T2 were significantly increased without significant alteration in cell water content. The relaxation times were more markedly affected in those with symptoms of delirium trements. These findings suggest that the intracellular free: bound water states rather than water content is the more likely explanation for these changes. The results are discussed in relation to similar findings obtained from in vivo studies in man and in vitro studies in animals.

Alterations in plasma lipids, lipoproteins and high density lipoprotein subfractions in peripheral arterial disease

AbstractThe concentrations of the major lipoprotein classes and of high density lipoprotein (HDL) subfractions in 63 male patients with arteriosclerosis of the lower limbs (claudication) were determined and compared with values from 63 healthy controls. The patients with peripheral arterial disease (PAD) had reduced levels of total HDL-cholesterol and HDL2b of large particle size, increased levels of small HDL3C particles and a high ratio of total plasma-cholesterol to HDL-cholesterol (coronary risk factor). The PAD patients, however, had lower levels of low density lipoprotein (LDL)-cholesterol but higher concentrations of very low density lipoprotein (VLDL)-cholesterol and plasma triglyceride than healthy subjects. This study therefore suggests that in PAD, the protective effect of HDL may be more important than the atherogenic effect of LDL. It further suggests that while HDL-cholesterol HDL2b and the ratio of total plasma-cholesterol to HDL-cholesterol may provide valid indices for identifying individuals at risk of PAD, other factors, such as LDL and total cholesterol, may not provide such an appropriate risk indicator.

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