Biography:

In the past Israel Nissenkorn has collaborated on articles with Rachel Rubinstein and Moshe Rehavi. One of their most recent publications is Affinity of nortriptyline to muscarinic receptors in the bladder and ileum of man and guinea-pig. Which was published in journal European Journal of Pharmacology.

More information about Israel Nissenkorn research including statistics on their citations can be found on their Copernicus Academic profile page.

Israel Nissenkorn's Articles: (9)

Affinity of nortriptyline to muscarinic receptors in the bladder and ileum of man and guinea-pig

AbstractThe antagonism by nortriptyline of carbachol- or urecholine-induced contractions was studied in strips of ileum and bladder derived from man and guinea-pig. Analyses of the results by the dose ratio method (Schild plots) showed significant differences in the affinities of the relevant muscarinic receptors to the antagonist: The Ki values in μM were as follows: Human ileum, 0.938; human bladder, 0.298; guinea-pig ileum, 0.159; guinea-pig bladder, 0.333 and 0.453. In man, the higher affinity of the drug to the receptors in the bladder than to those in the ileum may be of consequence in its therapeutic application as an antienuretic agent.

A comparative study of the affinities of some tricyclic antidepressants for the muscarinic cholinergic receptor in human and guinea-pig bladder, ileum and brain in relation to differential drug potency

AbstractFollowing a report that nortriptyline was found useful in the control of enuresis in adults, presumably as an anticholinergic, its likely mechanism of action and apparent bladder specificity have now been investigated in vitro. The ratios of anticholinergic potencies (reciprocal of dissociation contants, Ki) for four different tricyclic antidepressants, derived from competitive binding assays with (−)[3H]QNB in tissue homogenates, in the order (human) detrusor muscle / ileal longitudinal muscle / caudate, are as follows: Nortriptyline, 5/4/7; desipramine, 2/1/5/; clomipramine, 4/3/27; amitriptyline, 25/14/56. The apparent selective effect of nortriptyline on the bladder cannot be ascribed to its higher affinity to bladder receptors. Still, this drug is the least discriminatory of the four. Hence, at a given concentration, it is expected to affect tissue embodying a low density receptor pool sooner than tissue having a large receptor reserve. The ratios of the densities of (−)[3H]QNB binding sites in the order detrusor muscle / ileal muscle / cortex is 1/3/5, supporting the present contention. In the guinea-pig, the ratios of the anticholinergic potency in the order bladder / proximal ileum / distal ileum / cortex are as follows: Nortriptyline, 25/5/6/33; desipramine, 8/2/2/14; amitriptyline, 100/14/20/100; clomipramine, 17/3/5/33. Also, the ratios of the densities of binding sites are 1/6/5/2. Hence, data derived from assays in the guinea-pig are not representative of those derived from human tissue

Widespread dissemination of gelfoam particles complicating occlusion of renal circulation

AbstractEmbolization of renal circulation by Gelfoam particles in a thirty-two-year-old man with renal carcinoma was followed by retrograde regurgitation of the injected particles upstream, with resultant occlusion of the celiac trunk and the superior mesenteric artery. This was followed by a stormy clinical course, which the patient survived. Several possible explanations are offered for the occurrence of this complication.

Scientific articleEarly combined hormonal and chemotherapy for metastatic carcinoma of prostate

AbstractTwenty-five patients with confirmed Stage D carcinoma of the prostate were treated by a combination of bilateral orchiectomy, estrogen, and chemotherapy soon after diagnosis was established. Patients were given diethylstilbestrol (DES) 3 mg. daily, and a weekly intravenous injection of 5-fluorouracil (5-FU) 10 mg./Kg. and cyclophosphamide 10 mg./Kg. They were followed up for between sixteen and forty-two months. The majority of patients reported a subjective improvement. Objectively, the primary tumor shrunk by more than 50 per cent in 84 per cent of the patients, while in 64 per cent there was improvement in the lesions shown on bone scan. The cumulative survival rate during three and one-half years was 76.5 per cent. These encouraging preliminary results appear to justify the early initiation of combined therapy in larger numbers of patients with Stage D prostatic carcinoma.

Evaluation of cystography for detection of bladder carcinoma in mice Comparison with Urinary Cytology

AbstractCystography was compared to urinary cytology in an effort to determine whether or not this modality might be useful in the detection of FANFT-induced bladder tumors in mice. Compared to gross examination of the bladders in 24 mice, cystography had the same degree of accuracy as urinary cytology - 79.2 per cent. Comparison of the cystographic and cytologic diagnoses with histology revealed that cytology was more accurate, 79.2 vs 66.6 per cent. Cystography was especially helpful in detecting papillary tumors while cytology was more accurate in the detection of high-grade, high-stage tumors or carcinoma in situ (CIS). Cystography in mice can complement cytology as an additional useful technique for detection of bladder carcinoma.

Single and sequential combination intravesical chemotherapy of murine bladder cancer☆

AbstractWe investigated the effectiveness of intravesically administered drugs on the tumor incidence and tumor size in a FANFT-induced animal model for bladder cancer. In the first experiment 106 C3H/He mice were divided into a control and three treatment groups. Therapy consisted of either cis-diamminedichloroplatinum (II) (DDP), mitomycin C, or thio-tepa. There was a reduction in the tumor incidence in all treated groups; this was statistically significant for those receiving mitomycin C (p < 0.04) and DDP (p < 0.001). No significant difference in the mean or median tumor weight (an index of tumor volume) between the treated and control groups was found. In a second experiment intravesical combination chemotherapy was compared to single-agent therapy. Animals received either doxorubicin hydrochloride (Adriamycin), mitomycin C, thio-tepa, mitomycin C + doxorubicin, or mitomycin C + thio-tepa. Although there was no significant difference in tumor incidence among the groups with the exception of mice receiving thio-tepa, animals receiving sequential combination chemotherapy had lower mean and median bladder weights suggesting an improved therapeutic effect.

Effect of Media and Growth Promoters on in Vitro Cultivation of Normal Murine Urinary Bladder Epithelium

AbstractGrowth potential of normal murine epithelium was investigated by means of 3 culture media: RPMI 1640 with fetal calf serum, Dulbecco’s with fetal calf serum and McCoy’s with horse serum. The effect of 3 growth promoters was tested separately with each of the 3 media. A total of 886 explants were cultured from 129 murine bladders and epithelial outgrowth was obtained in 35.2 per cent. The growth medium 1640 with 20 per cent fetal calf serum and epithelial growth factor produced the most abundant outgrowth of explants. McCoy’s medium containing 15 per cent horse serum produced significantly lower outgrowth compared to the medium containing fetal calf serum (p <0.001). Epidermal growth factor has a stimulating effect and horse serum has an inhibitory effect on growth of normal murine epithelial cells.

The Clonogenic Growth of Cells Derived From Bladder Barbotage in Patients With Transitional Cell Carcinoma of the Bladder: A Preliminary Report

AbstractTumor cells obtained from bladder washings in 41 patients with transitional cell carcinoma of the bladder and 15 control subjects were analyzed for their ability to produce cluster and/or colony formation in a tumor stem cell assay. In vitro cell growth was correlated with the presence of tumor at the time of bladder washing, tumor grade and treatment status. Of 34 bladder washings from patients with biopsy-proved transitional cell carcinoma 88 per cent produced cluster and/or colony formation. Specimens from patients not currently receiving intravesical chemotherapy at the time of bladder barbotage produced colonies in 54 per cent of the cases, compared to 25 per cent from patients receiving therapeutic or maintenance therapy. Higher grade tumors produced more viable cells at bladder barbotage but clonal growth rates were independent of histologic grade. We conclude that bladder barbotage may serve as a source of cells for chemotherapeutic drug testing in patients with transitional cell carcinoma of the bladder. Bladder washings also may be useful as a source of tumor cells for monitoring the in vivo growth potential of bladder cancer in the tumor stem cell assay.

The Treatment of Osteitis Pubis with Heparin

AbstractWe treated 7 patients with osteitis pubis by heparinization. Of the 7 patients 2 had a dramatic improvement. Small doses of heparin given routinely preoperatively and postoperatively were not found to prevent the development of osteitis pubis. In view of these results as well as the fact that there presently is no effective method of treatment of this disorder, it is considered justifiable to subject all patients with postoperative osteitis pubis to a therapeutic trial with heparinization.

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