Biography:

One of their most recent publications is Prolonged depolarization of rat cerebral synaptosomes leads to an increase in vesicular glutamate content. Which was published in journal Neuroscience Letters.

More information about David G. Bole research including statistics on their citations can be found on their Copernicus Academic profile page.

David G. Bole's Articles: (1)

Prolonged depolarization of rat cerebral synaptosomes leads to an increase in vesicular glutamate content

AbstractGlutamate accumulation into synaptic vesicles is a vital step in glutamate synaptic transmission. In this study, we have explored the possibility that vesicular glutamate storage may be subject to some regulation. Synaptosomes were depolarized and subjected to [3H] glutamate under non-depolarizing conditions, and vesicular [3H] glutamate content was determined by a filter-based assay. We present evidence here that prolonged depolarization of synaptosomes leads to an increase in vesicular glutamate content. Induction of this enhanced state is time- and temperature-dependent. The enhanced state has two components, one readily reversible and the other long-lasting. The up-regulation of glutamate storage capacity could lead to an increase in quantal size and play a role in modulation of glutamate transmission efficiency.

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