AbstractIminopyridines were found to be a sort of efficient bidentate ligands for the palladium(II)-catalyzed cyclization of (Z)-4′-acetoxy-2′-butenyl 2-alkynoates in acetic acid to afford the α-(Z)-acetoxyalkylidene-β-vinyl-γ-butyrolactones. The iminopyridine ligands could not only inhibit β-hydride elimination but also stabilize the vinyl-palladium intermediate in acetic acid in the reaction.
Highlights•Copper-exchanged montmorillonites can be an alternative to antibiotic in weaned pigs.•No difference was observed in the in vivo efficiency of the Cu*Ca-MMT and Cu*Na-MMT.•Both of Cu-MMT improved growth performance and alleviated diarrhea in weaned pigs.•Both of Cu-MMT lowered Clostridium and Escherichia coli in ileum and proximal colon.•Both of Cu-MMT reduced weaning-induced inflammation and improved intestinal barrier.
AbstractAim: To study dynamic changes in the hemodynamic parameters in pregnant women during different weeks of gestation and to comprehend changes to the cardiovascular system in normal pregnant women and in patients with pregnancy-induced hypertension (PIH), with the object of finding predictors of pregnancy-induced hypertension. Methods: Radialis artery pulse waves of 132 pregnant women were examined from 10 weeks of gestation onward, and the subjects’ hemodynamics were examined every 4 weeks. Results: In the women with PIH hemodynamic changes occurred earlier than the onset of disease and even presented in early pregnancy; there might be another mode, and there were factors disturbing the blood pressure modulating mechanism. Conclusion: The prediction of PIH from the dynamic changes in hemodynamic parameters has significant implications for clinical practice.
Highlights•X-chromosome dosage modulates the pluripotent chromatin accessibility landscape•Increased X-chromosome dosage slows down growth•Dusp9 heterozygous female ESCs display pluripotency exit delay