Biography:

In the past Ronald J. Barr has collaborated on articles with Matthew M. Goodman and Burson T. Williams. One of their most recent publications is Original ArticleA Model of Human Melanoma in Cyclosporine-Immunosuppressed Rats. Which was published in journal Journal of Investigative Dermatology.

More information about Ronald J. Barr research including statistics on their citations can be found on their Copernicus Academic profile page.

Ronald J. Barr's Articles: (5)

Original ArticleA Model of Human Melanoma in Cyclosporine-Immunosuppressed Rats

A human malignant melanoma maintained in athymic nude mice has been successfully implanted and grown in cyclosporine (Cys-)immunosuppressed Lewis rats. Suspended melanoma cells (106) or solid tumor sections measuring 2–4 mm in diameter were implanted s.c. in rats receiving parenteral Cys doses of 15–50 mg/kg each day for 1 weeks, and 3 times per week thereafter. Eighty-five percent of solid tumor section implanted in animals receiving 25 mg/kg resulted in tumor growth, whereas no tumors grew from cell suspension injection sites. The average maximum tumor growth rate was 2 cm3/day, with a doubling time of 8 days. Tumors retained pretransplant gross and microscopic morphology, karyotype, and labeling index. Possible advantages of this model over the athymic nude mouse include greater longevity, larger animal and tumor size, and less stringent aseptic environmental requirements. This model may prove useful for further study of the pathophysiology of melanoma and for testing of new antimelanoma therapies.

Immunoperoxidase staining of cytoplasmic immunoglobulins: A diagnostic aid in distinguishing cutaneous reactive lymphoid hyperplasia from malignant lymphoma**

A method for staining cytoplasmic immunoglobulins utilizing an immunoperoxidase technic on paraffin-embedded tissue was used to examine two cutaneous lesions. On routine hematoxylin-eosin staining, one lesion exhibited what appeared to be a mixed population of mature cell types and was therefore interpreted as reactive lymphoid hyperplasia, whereas the other lesion showed a uniform population of immature cells and was interpreted as a malignant lymphoma. Immunoperoxidase staining supported these interpretations since the reactive lesion showed polyclonal IgGλ and κ staining, and the malignant lymphoma monoclonal staining with IgGλ. In selected material, immunoperoxidase staining can distinguish a truly mixed population of cell types (probably benign) from a monoclonal population of cells exhibiting either uniform or mixed morphologic configurations associated with B lymphocyte transformation (probably malignant).

Necrobiotic granulomas associated with bovine collagen test site injections

Two patients are presented who developed persistent nodules at the test site after bovine collagen injections. Biopsies were taken, and both exhibited the histologic features of necrobiotic granulomatous inflammation.

Cutaneous cytology2

AbstractCutaneous cytology is the study of scrapings or smears obtained from lesions of the skin. Although not commonly employed, cutaneous cytology has become a useful tool for clinicians due to the development of simplified procedures and staining technics. This review describes basic principles and illustrates the usefulness of cutaneous cytology in studying selected vesiculobullous and pustular dermatoses, neoplasms, superficial fungal infections, and miscellaneous applicable disorders. Sophisticated diagnostic tumor cytology and new methodology, such as immunohistochemistry and intricate morphometric analyses, are also briefly discussed.

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