Biography:

In the past James B. Kobler has collaborated on articles with Sandra Merscher and Ernest W. Chang. One of their most recent publications is The recruitment order of stapedius motoneurons in the acoustic reflex varies with sound laterality. Which was published in journal Brain Research.

More information about James B. Kobler research including statistics on their citations can be found on their Copernicus Academic profile page.

James B. Kobler's Articles: (4)

The recruitment order of stapedius motoneurons in the acoustic reflex varies with sound laterality

AbstractIn many muscles, motor units are recruited in a fixed order with increasing strength of muscular contraction. We show that for the stapedius muscle of the cat, vastly different recruitment orders can be obtained, depending on which ear is acoustically stimulated. The data support the idea that the distribution of inputs to a motoneuron pool can be inhomogeneous and a significant factor in determining recruitment order.

The recruitment order of stapedius motoneurons in the acoustic reflex varies with sound laterality

AbstractIn many muscles, motor units are recruited in a fixed order with increasing strength of muscular contraction. We show that for the stapedius muscle of the cat, vastly different recruitment orders can be obtained, depending on which ear is acoustically stimulated. The data support the idea that the distribution of inputs to a motoneuron pool can be inhomogeneous and a significant factor in determining recruitment order.

TBX1 Is Responsible for Cardiovascular Defects in Velo-Cardio-Facial/DiGeorge Syndrome

AbstractVelo-cardio-facial syndrome (VCFS)/DiGeorge syndrome (DGS) is a human disorder characterized by a number of phenotypic features including cardiovascular defects. Most VCFS/DGS patients are hemizygous for a 1.5–3.0 Mb region of 22q11. To investigate the etiology of this disorder, we used a cre-loxP strategy to generate mice that are hemizygous for a 1.5 Mb deletion corresponding to that on 22q11. These mice exhibit significant perinatal lethality and have conotruncal and parathyroid defects. The conotruncal defects can be partially rescued by a human BAC containing the TBX1 gene. Mice heterozygous for a null mutation in Tbx1 develop conotruncal defects. These results together with the expression patterns of Tbx1 suggest a major role for this gene in the molecular etiology of VCFS/DGS.

Research paperSimultaneous 3D imaging of sound-induced motions of the tympanic membrane and middle ear ossicles

Highlights•Introducing a novel OCT technique for visualizing the sound-induced motion of the TM and ossicles with three-dimensional resolution.•Imaging sound-induced motion of stapes through the intact TM.•Optical vibrography distinguishes different pathologies in the middle ear.

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