Biography:

In the past Jason W Chin has collaborated on articles with Stacey E Rutledge and T Ashton Cropp. One of their most recent publications is Methodology for optimizing functional miniature proteins based on avian pancreatic polypeptide using phage display. Which was published in journal Bioorganic & Medicinal Chemistry Letters.

More information about Jason W Chin research including statistics on their citations can be found on their Copernicus Academic profile page.

Jason W Chin's Articles: (4)

Methodology for optimizing functional miniature proteins based on avian pancreatic polypeptide using phage display

AbstractSynthetic genes for avian pancreatic polypeptide (aPP) and for the miniature DNA binding protein PPBR4 were cloned and expressed on the surface of M13 bacteriophage. We anticipate that these constructs will have utility optimizing the properties of miniature proteins based on aPP that result from our previously described protein grafting procedure.

ReviewA view to a kill: ligands for Bcl-2 family proteins

AbstractApoptosis is the essential process of programmed cell death that, in multicellular organisms, regulates development and maintains homeostasis. Defects in the apoptotic molecular machinery that result in either excessive or insufficient apoptosis are observed in a remarkably wide range of human disease, prompting intense interest in pro- and anti-apoptotic proteins as therapeutic targets. A number of recent reports have described the discovery of ligands for anti-apoptotic Bcl-2 family proteins by a variety of approaches, including computational, combinatorial and evolutionary strategies. Both the design of ligands and the exploration of their mechanisms of action have been greatly enhanced by recent high-resolution structure determinations of proteins from this family. Several of the newly discovered ligands promote apoptosis, and some do so even in the face of overexpressed anti-apoptotic Bcl-2 proteins. Ligands that overcome the protective effects associated with up-regulation of anti-apoptotic Bcl-2 proteins represent especially promising therapeutic leads.

Expanding nucleic acid function in vitro and in vivo

Nucleic Acids composed of the five natural bases and a phosphate backbone can be designed or evolved to have a wide variety of sequence-dependent functions. Recent in vitro work has addressed some outstanding issues in evolving nucleic acid catalysts, as well as the creation of prescribed shapes and arrays from oligonucleotides and long single-stranded nucleic acids. Nucleic acids have also been engineered in vivo, leading to new modes of gene regulation. It is likely that the improving ability to synthesize long DNA sequences will accelerate the creation of novel functions from nucleic acids.

Genetic code expansion and bioorthogonal labelling enables cell specific proteomics in an animal

Highlights•The PylRS/tRNACUA pair is a versatile tool for site-specific incorporation of unnatural amino acids in proteins.•Inverse electron demands Diels Alder reaction of tetrazines enable rapid bioorthogonal labelling of proteins in vivo.•SORT-M labels proteins at diverse codons using diverse bioorthogonal chemistry via PylRS/tRNAXXX pairs.•SORT-M labels proteomes in spatially and temporally defined sets of cells without starvation.•SORT-M has been used for tissue-specific and developmental stage-specific proteome labelling and protein identification in the fly.

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