In the past Yu Yu has collaborated on articles with Angelica M. Merlot and Tian Shen. One of their most recent publications is Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase. Which was published in journal Biochemical Pharmacology.

More information about Yu Yu research including statistics on their citations can be found on their Copernicus Academic profile page.

Yu Yu's Articles: (37)

Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase

AbstractThe endoplasmic reticulum (ER) plays a major role in the synthesis, maturation and folding of proteins and is a critical calcium (Ca2+) reservoir. Cellular stresses lead to an overwhelming accumulation of misfolded proteins in the ER, leading to ER stress and the activation of the unfolded protein response (UPR). In the stressful tumor microenvironment, the UPR maintains ER homeostasis and enables tumor survival. Thus, a novel strategy for cancer therapeutics is to overcome chronically activated ER stress by triggering pro-apoptotic pathways of the UPR. Considering this, the mechanisms by which the novel anti-cancer agent, Dp44mT, can target the ER stress response pathways were investigated in multiple cell-types. Our results demonstrate that the cytotoxic chelator, Dp44mT, which forms redox-active metal complexes, significantly: (1) increased ER stress-associated pro-apoptotic signaling molecules (i.e., p-eIF2α, ATF4, CHOP); (2) increased IRE1α phosphorylation (p-IRE1α) and XBP1 mRNA splicing; (3) reduced expression of ER stress-associated cell survival signaling molecules (e.g., XBP1s and p58IPK); (4) increased cleavage of the transcription factor, ATF6, which enhances expression of its downstream targets (i.e., CHOP and BiP); and (5) increased phosphorylation of CaMKII that induces apoptosis. In contrast to Dp44mT, the iron chelator, DFO, which forms redox-inactive iron complexes, did not affect BiP, p-IRE1α, XBP1 or p58IPK levels. This study highlights the ability of a novel cancer therapeutic (i.e., Dp44mT) to target the pro-apoptotic functions of the UPR via cellular metal sequestration and redox stress. Assessment of ER stress-mediated apoptosis is fundamental to the understanding of the pharmacology of chelation for cancer treatment.

The morphological changes of monocytes in peripheral blood as a potential indicator for predicting active pulmonary tuberculosis

Highlights•The morphology present on monocytes in peripheral blood for discriminating  APTB patients from NHS was conducted.•A significant increase in the MMV and MDW was observed in the APTB patients compared to NHS.•The MMV had positive relationship with the serum level of IL-1β response to M. tuberculosis infection.•Simultaneous measurement of the MMV and MDW was able to distinguish APTB with excellent sensitivity and specificity.

The long-range effect induced by untying hydrogen bonds for single cell test using SECM

Highlights•The enhanced positive feedback current of SECM is observed at a large tip-substrate separation in the case of a 3-MPA SAM.•The long-range effect is resulting from concentration increment of redox species by untying the hydrogen bonds beforehand formed between the tip redox species and the 3-MPA SAM.•The long-range effect is applied to the single cell test using SECM which is beneficial for cell tests without affecting the natural metabolic pathway and cell morphology.

FERM-containing protein FRMD5 is a p120-catenin interacting protein that regulates tumor progression

AbstractFERM family proteins have been known to play an important role in tumor progression. FERM-domain containing protein 5 (FRMD5), a novel putative cytoskeletal protein, is an unknown function protein. Here, we reported that FRMD5 localized at the cell adherens junction and formed a molecular complex with p120-catenin through its C-terminal region. Functionally, we found that knockdown of endogenous FRMD5 promotes lung cancer cell migration and invasion in vitro as well as tumor growth in vivo, suggesting a tumor suppressive effect. These findings indicated that FRMD5 may play a role in p120-catenin-based cell–cell contact and is involved in the regulation of tumor progression.Structured summary of protein interactionsFRMD5 and p120 catenin colocalize by fluorescence microscopy (View interaction) FRMD5 physically interacts with p120 catenin by anti tag coimmunoprecipitation (View interaction)FRMD5 and Beta-catenin colocalize by fluorescence microscopy (View interaction)FRMD5 and gamma-catenin colocalize by fluorescence microscopy (View interaction) FRMD5 physically interacts with p120 catenin and E cadherin by anti bait coimmunoprecipitation (View interaction)

Synthesis, structure, cytotoxic activities and DNA-binding properties of tetracopper(II) complexes with dissymmetrical N,N′-bis(substituted)oxamides as ligands

AbstractTo compare the cytotoxicities and the DNA-binding properties in tetranuclear complexes with different bridging ligands, two tetracopper(II) complexes with formulae of [Cu4(oxbe)2Cl2(bpy)2]·4H2O (1) and [Cu4(oxbm)2Cl2(bpy)2]·2H2O (2) were synthesized, where H3oxbe and H3oxbm stand for N-benzoato-N′-(2-aminoethyl)oxamide and N-benzoato-N′-(1,2-propanediamine)oxamide, respectively, and bpy is 2,2′-bipyridine. Complex 1 was characterized by elemental analyses, IR and electronic spectra and single-crystal X-ray diffraction. The crystal structure reveals the presence of the circular tetranuclear copper(II) cations which are assembled by a pair of cis-oxamido-bridged dinuclear copper(II) units through carboxyl bridges. The crystal structure of complex 2 has been reported in our previous paper. However, the bioactivities were not studied. Cytotoxicities experiments reveal that both the two complexes exhibit cytotoxic effects against human hepatocellular carcinoma cell SMMC-7721 and human lung adenocarcinoma cell A549, and complex 1 has the better activities than those of complex 2. The results of the interactions between the two complexes and herring sperm DNA (HS-DNA) suggest that the two complexes interact with HS-DNA in the mode of intercalation with the intrinsic binding constants of 3.93 × 104 M−1 (1) and 2.48 × 104 M−1 (2). These results indicated that the bridging ligands may play an important role in the cytotoxicities and the DNA-binding properties of tetranuclear complexes.

Public key encryption resilient to leakage and tampering attacks

Highlights•Formalize LTR-CCA security w.r.t. both bounded-memory and auxiliary-input leakage.•Introduce the notion of KH-HPS, and present a generic construction of LTR-CCA PKE.•Get the 1st PKE secure against both auxiliary-input leakage and tampering attacks.•Give several instantiations based on some standard number-theoretical assumptions.

Research-ArticleDehydrated Poultry Waste as a Feed for Milking Cows and Growing Sheep1

AbstractDehydrated feces from caged layers were fed to milking cows to provide 23% of total dietary protein and 11% of total dry matter intake and to fattening sheep to provide 61 or 90% of total dietary protein and 25 or 50% of feed intake. Cows fed these dehydrated feces produced more milk than those fed inadequate protein and produced equal amount to those fed usual protein supplements. Sheep fed rations containing 25 or 50% dehydrated feces gained .16 and .15 kg/day which was significantly less than those fed a control corn-corn cob-soybean meal ration (.21 kg/day). Carcass grade of those fed 25% feces was equal to that of control lambs. When the dehydrated feces cost $20/908 kg, then feed cost per unit gain was similar to that of control lambs. Results indicate the feasibility of using relatively large amounts of dehydrated caged layer feces as a nitrogen and energy source for cows and lambs.

Research-articleFermented Bovine Colostrum for Holstein Replacement Calf Rearing

AbstractColostrum (composite of the first six milkings) from 85 Holstein cows was stored individually for 7 days at room temperature and then pooled for storage of 35 days. Analyses of composition for 20 cows gave means of percent acidity, pH, total solids, lactose, protein, nonprotein nitrogen as a percent of total nitrogen, and fat contents of the initial and 7-day old fermented colostrum as .534, 1.049%; 5.91, 4.74%; 20.06, 15.52%; 3.16, 3.25%; 10.56, 6.47%;4.46, 7.16%; and 5.38, 5.01%. Contents of lactose, total solids, and protein reduced slightly further for colostrum stored longer than 7 days (8 to 35). Forty Holstein female calves were fed either 1) 1.64 kg whole milk, or 2) .9 kg fermented colostrum plus .9 kg water twice daily from birth until weaning at 5 wk during autumn, winter, and spring. A 20% crude protein starter was available to calves during the experimental period. Growth was not different between treatments. Calves of group 1 consumed comparable total dry matter but less amount of crude protein than calves of group 2 (23.5 versus 22.5 kg for dry matter and 2.91 versus 3.53 kg for crude protein). Starter consumption was consistently greater for calves of group 2 than calves of group 1 (13.3 versus 10.6 kg/35 days). Number of calves treated for diarrhea was six for group 1 and two for group 2. Feed cost was reduced by 90% with fermented colostrum feeding program as compared to the whole milk feeding program.

Balanced 2p-variable rotation symmetric Boolean functions with optimal algebraic immunity, good nonlinearity, and good algebraic degree

AbstractIn designing cryptographic Boolean functions, it is challenging to achieve at the same time the desirable features of algebraic immunity, balancedness, nonlinearity, and algebraic degree for necessary resistance against algebraic attack, correlation attack, Berlekamp–Massey attack, etc. This paper constructs balanced rotation symmetric Boolean functions on n variables where n=2p and p is an odd prime. We prove the construction has an optimal algebraic immunity and is of high nonlinearity. We check that, at least for those primes p which are not of the form of a power of two plus one, the algebraic degree of the construction achieves in fact the upper bound n−1.

Finite mixture models for sensitivity analysis of thermal hydraulic codes for passive safety systems analysis

Highlights•Uncertainties of TH codes affect the system failure probability quantification.•We present Finite Mixture Models (FMMs) for sensitivity analysis of TH codes.•FMMs approximate the pdf of the output of a TH code with a limited number of simulations.•The approach is tested on a Passive Containment Cooling System of an AP1000 reactor.•The novel approach overcomes the results of a standard variance decomposition method.

Eleven-wavelength switchable fiber ring laser with a dispersion compensation fiber and a delayed interferometer

AbstractWe demonstrate a fiber ring laser with a dispersion compensation fiber (DCF) and a delayed interferometer (DI) with temperature control, which is able to switch eleven wavelengths one by one. In ring cavity, DCF supplies different effective cavity lengths for different wavelengths, DI generates a wavelength comb corresponding to the ITU grid, a flat-gain erbium-doped fiber amplifier (EDFA) provides uniform gain for each lasting wavelength, and a semiconductor optical amplifier (SOA) not only acts as active modulator, but also alleviates homogeneous broadening effect of EDFA. Stable pulse trains with a pulsewidth about 40 ps at 10 GHz have been obtained by injecting external optical control signals into the laser. Wavelength switching process among eleven wavelengths is achieved by merely tuning an intracavity optical delay line.

Simultaneous all-optical multi-channel RZ and CSRZ to NRZ format conversion

AbstractWe propose and demonstrate multi-channel all-optical return-to-zero (RZ) and carrier-suppressed RZ (CSRZ) to non-return-to-zero (NRZ) format conversions using a same fiber delay-interferometer (DI). The conversions are based on simultaneous constructive interference induced by the periodical comb-like filtering characteristic of the DI. By using a DI with free spectral range of 40 GHz, 8 channel RZ and CSRZ signals at 20 Gb/s can be converted to corresponding NRZ signals at the same time. Furthermore, a duplicate output can be obtained for multi-channel CSRZ input. Bit error ratio measurements show 4 and 3.5 dB penalties for the proposed multi-channel RZ and CSRZ to NRZ conversions respectively. Further transmission for the converted NRZ signals verifies the good performance of the proposed all-passive multi-channel format converter. The potential of multi-channel RZ signals with mixed duty-cycle to NRZ conversions is also investigated.

CMOS-compatible polarizer with tilted polarization angle

AbstractA novel CMOS-compatible polarizer with tilted polarization angle is proposed and theoretically analyzed. It is the first time, to the best of our knowledge, that an on-chip polarizer with polarization angle other than 0°or 90°is investigated. The polarizer consists of a waveguide, a cladding etched trench and a metal strip. The trench and metal break the symmetry of the waveguide structure and rotate the polarization axes, while the metal also attenuates the specific polarization component. The proposed polarizer is comprehensively investigated from design to fabrication tolerance and 3 different cases with polarization angle 30°, 45°and 60°are demonstrated. The simulated results reveal that extinction ratio as large as 20 dB at 1550 nm can be achieved with excess loss as low as 1 dB, over 100 nm wavelength range. Furthermore, the Monte Carlo analysis shows the feasibility of the proposed polarizer in terms of practical fabrication.

Spatial decomposition analysis of water intensity in China

Highlights•Spatial difference of water intensity in the six regions are decomposed into intensity effect and structure effect.•Three industrial differences of the intensity effect and the structure effect in the six regions in China are measured.•Spatial differences of water intensity for provinces in China are decomposed into intensity effect and structure effect.

Highly sensitive nonenzymatic glucose sensor based on nickel nanoparticle–attapulgite-reduced graphene oxide-modified glassy carbon electrode

Highlights•A facile one-step electrochemical co-deposition approach is adopted, referring to simultaneous depositions of, attapulgite (ATP), cathodic reduction of Ni2+ into nickel nanoparticles under acidic conditions, and in situ reduction of graphene oxide (GO).•The size and morphology of Ni nanoparticles will be improved by introduction of co-deposition of ATP, resulting in enhancement in electrochemical activity.•The as-prepared NiNPs/ATP/RGO-based glucose sensor exhibits outstanding performance for enzymeless glucose sensing with sensitivity (1414.4 μA mM−1 cm−2), linear range (1–710 μM) and detection limit (0.37 μM).•NiNPs/ATP/RGO exhibited a high selectivity towards glucose against the interferents, such as ascorbic acid (AA), 4-Aminophenol (AP), and uric acid (UA).

SeriesThe magnitude of and health system responses to the mental health treatment gap in adults in India and China

SummaryThis Series paper describes the first systematic effort to review the unmet mental health needs of adults in China and India. The evidence shows that contact coverage for the most common mental and substance use disorders is very low. Effective coverage is even lower, even for severe disorders such as psychotic disorders and epilepsy. There are vast variations across the regions of both countries, with the highest treatment gaps in rural regions because of inequities in the distribution of mental health resources, and variable implementation of mental health policies across states and provinces. Human and financial resources for mental health are grossly inadequate with less than 1% of the national health-care budget allocated to mental health in either country. Although China and India have both shown renewed commitment through national programmes for community-oriented mental health care, progress in achieving coverage is far more substantial in China. Improvement of coverage will need to address both supply-side barriers and demand-side barriers related to stigma and varying explanatory models of mental disorders. Sharing tasks with community-based workers in a collaborative stepped-care framework is an approach that is ripe to be scaled up, in particular through integration within national priority health programmes. India and China need to invest in increasing demand for services through active engagement with the community, to strengthen service user leadership and ensure that the content and delivery of mental health programmes are culturally and contextually appropriate.

Effect of Nu correlation uncertainty on safety margin for passive containment cooling system in AP1000

Highlights•Nu correlation is fitted for PCCS in AP1000.•Probabilistic density distribution of (Nue/Nuc) is fitted.•Influence of Nu correlation uncertainty on system safety margin is evaluated.•Uncertainties in Nu correlation and parameters influence each other.•It is suitable to consider Nu correlation uncertainty in system reliability model.

A dynamic duopoly model with bounded rationality based on constant conjectural variation

Highlights•We construct dynamic models on the basis of constant conjectural variation.•We consider constructing a dynamic system of duopolists with bounded rationality.•The complexion of dynamic models is analyzed by numerical simulation.•Bifurcation and chaos occur with the speed of output adjustment increasing.•Strange attractors and fractal dimensions are also shown in this article.

Frequency fine adjusting of LTCC microwave resonators based on BZN ceramics

AbstractBZN-based ceramics with low sintering temperature were prepared using a conventional route. Green sheets of ceramics were formed using tape casting technique. The laminated tapes were pressed together for forming multilayer microwave resonators. The green chips were sintered at about 950 °C. In order to adjust the resonant frequency of resonator, the width of the ground terminal electrode of the stripline can be changed. When the width of the ground terminal electrode varied from 1.0 to 2.4 mm, the resonant frequency of resonator changed from 0.971 GHz to 0.986 GHz. As the width of the ground terminal electrode increased, the resonant frequency of resonator varied slowly and then saturated. The maximum adjusting value of the resonant frequency of resonator is about 1.5%.

Research papersDistribution, sources and budgets of particulate phosphorus and nitrogen in the East China Sea

AbstractSuspended particles were collected from the northern East China Sea (ECS) in four spring and autumn cruises to study the sources and biogeochemical behavior of particulate inorganic and organic phosphorus and nitrogen (PIP, POP, PIN, and PON). PIP and PON were dominant forms of particulate P and N, accounting for 57.2% of TPP and 78.2% of TPN, respectively. PIP and POP concentrations decreased seaward from the estuary, and had high values near Zhoushan Islands and in the northern ECS. It was indicated that the Changjiang dilute water (CDW) and the Jiangsu coastal currents (JCC), which were rich in particulate phosphorus were the major sources of PIP and POP. PIN and PON concentrations exhibited decreasing trend from the middle shelf toward land and offshore, suggesting the dilution effect of N-depleted riverine particles on particulate nitrogen in coastal waters. The highest concentrations of PIN and PON were observed in the coast of Zhejiang and in the northern ECS, which were two productive areas in the ECS. PON and PIN were primarily of marine source and POP was also influenced by phytoplankton productivity. The concentrations, compositions and distribution of particulate nutrients varied between spring and autumn, in response to the seasonal variations of phytoplankton productivity and terrestrial input. Budget calculation demonstrated that the sediment flux of Changjiang accounted for 88% of total input flux in spring and summer, indicating that the Changjiang River was the major particle source in the ECS. Particulate P was mainly from phytoplankton and the input of the Changjiang River, while the major source of particulate N was phytoplankton. Phytoplankton production contributed 70% of TPP input flux and 95% of TPN input flux in spring and summer, while 64% of TPP input and 89% of TPN input in autumn and winter. It was shown that riverine particles were enriched in inorganic P, whereas marine particles had high organic P and N content, which suggested that the component characteristics of particles could be used to identify the particle sources.

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