Biography:

In the past Susumu Iketani has collaborated on articles with Hiroyuki Yamada. One of their most recent publications is Gene Expression of 5-Fluorouracil Metabolic Enzymes in Head and Neck Squamous Cell Carcinomas. Which was published in journal Asian Journal of Oral and Maxillofacial Surgery.

More information about Susumu Iketani research including statistics on their citations can be found on their Copernicus Academic profile page.

Susumu Iketani's Articles: (2)

Gene Expression of 5-Fluorouracil Metabolic Enzymes in Head and Neck Squamous Cell Carcinomas

AbstractObjective: To measure the gene expression of the metabolic enzymes of 5 fluorouracil (thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate phosphoribosyltransferase) to assess the efficacy of 5 fluorouracil inpatients with head and neck cancerPatients and Methods: Tissue specimens of 64 patients with head and neck cancer (41 men and 23 women with a mean age of 62.6 years) who had been surgically treated from April 1997 to March 2004 were included in this study. The mRNA expressions of thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate phosphoribosyltransferase genes were examined from the surgically resected tissues using the Danenberg tumour profile method. The mRNA levels of the 4 enzymes were compared between tumour tissues and adjacent healthy tissues.Results: All specimens showed that thymidylate synthase, thymidine phosphorylase, and orotate phosphoribosyltransferase levels were significantly higher in the primary tumours than in the adjacent healthy tissues, while the levels of dihydropyrimidine dehydrogenase were significantly lower in the primary tumours than in the adjacent healthy tissues.Conclusion: Prediction of the efficacy of 5 fluorouracil therapy in the treatment of head and neck cancer from the measurement of mRNA levels of its metabolic enzymes appears to be feasible and possibly beneficial. Key words: Head and neck neoplasms, Orotate phosphoribosyltransferase, Thymidine phosphorylase, Thymidylate synthase

Feasibility of Blue Dye Method to Identify Sentinel Lymph Node Metastasis in Patients with Oral Cancer

AbstractObjective: To examine the feasibility of a combination of the blue dye injection method and reverse transcriptase-nested polymerase chain reaction for squamous cell carcinoma antigen mRNA to detect sentinel lymph node metastasis in patients with oral cancer.Patients and Methods: Ten individuals with previously untreated oral cancer participated in the study. Sentinel lymph nodes were identified by the blue dye injection method during neck dissection. We investigated the comparative effectiveness of frozen haematoxylin and eosin section analysis and molecular analysis of squamous cell carcinoma antigen for sentinel lymph node diagnosis.Results: In 8 out of the 10 cases, sentinel lymph nodes were identified. One histologically positive sentinel lymph node also showed positive for squamous cell carcinoma antigen. The remaining 7 histologically negative sentinel lymph nodes were also negative for squamous cell carcinoma antigen. However, in 3 cases, squamous cell carcinoma antigen-positive-non-sentinel lymph nodes were detected despite sentinel lymph nodes being negative for squamous cell carcinoma antigen.Conclusion: Our preliminary results suggest that the combination of the single blue dye injection method and reverse transcriptase-nested polymerase chain reaction for the squamous cell carcinoma antigen mRNA was not very accurate for detection of sentinel lymph node metastasis in patients with oral cancer.

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