Biography:

In the past Jun Hee Lee has collaborated on articles with Woo Han Kim and Jahyo Kang. One of their most recent publications is Concise synthesis of the xenibellols core. Which was published in journal Tetrahedron Letters.

More information about Jun Hee Lee research including statistics on their citations can be found on their Copernicus Academic profile page.

Jun Hee Lee's Articles: (15)

Concise synthesis of the xenibellols core

AbstractWe describe herein a concise synthesis of an intermediate, via 2,3-Wittig rearrangement and Williamson etherification, en route to the natural products, xenibellols A and B.

An ionic Diels–Alder route to cis-fused octalins containing an all-carbon quaternary stereocenter in an angular position

AbstractWe describe herein the development of efficient and stereoselective synthetic routes to a series of cis-octalins possessing an all-carbon quaternary center in an angular position.

Asymmetric synthesis of a new cylindrically chiral and air-stable ferrocenyldiphosphine and its application to rhodium-catalyzed asymmetric hydrogenation

AbstractA novel, cylindrically chiral air-stable ferrocenyldiphosphine ligand has been synthesized and its rhodium complexes have been applied to asymmetric hydrogenation. High reactivity and selectivity have been realized in hydrogenation of various dehydroamino acid derivatives.

Combination of MSC spheroids wrapped within autologous composite sheet dually protects against immune rejection and enhances stem cell transplantation efficacy

Highlights•MSC: MSC spheroids produced more angiogenic cytokines and ECM molecules.•MSC spheroids showed high IDO expression and low macrophage proliferation.•MSC spheroids in cell sheets caused high survival and low inflammatory response.

ArticleDietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

SummaryEpidemiological studies indicate that overweight and obesity are associated with increased cancer risk. To study how obesity augments cancer risk and development, we focused on hepatocellular carcinoma (HCC), the common form of liver cancer whose occurrence and progression are the most strongly affected by obesity among all cancers. We now demonstrate that either dietary or genetic obesity is a potent bona fide liver tumor promoter in mice. Obesity-promoted HCC development was dependent on enhanced production of the tumor-promoting cytokines IL-6 and TNF, which cause hepatic inflammation and activation of the oncogenic transcription factor STAT3. The chronic inflammatory response caused by obesity and enhanced production of IL-6 and TNF may also increase the risk of other cancers.

In vivo evaluation and characterization of a bio-absorbable drug-coated stent fabricated using a 3D-printing system

Highlights•A bioabsorbable sirolimus-eluting stent was successfully fabricated using a 3D-printing system.•The release of sirolimus from stent was maintained up to 31 days in vitro.•A pilot porcine study was used to demonstrate the in vivo behavior of the bioabsorbable sirolimus-eluting stent produced in this study.

Sphalerite geochemistry of the Zn-Pb orebodies in the Taebaeksan metallogenic province, Korea

Highlights•The Zn-Pb orebodies in the Taebaeksan region were formed by magmatic-hydrothermal activities.•Economic Zn-Pb mineralization is associated with minimal fluid-rock interaction.•Trace elements in sphalerites show a temperature-dependent systematic trend.•Geochemistry of the sphalerite provides insights regarding hidden Zn-Pb orebody.

ArticleTransneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

Highlights•Gut-to-brain propagation of pathologic α-synuclein via the vagus nerve causes PD•Dopamine neurons degenerate in the pathologic α-synuclein gut-to-brain model of PD•Gut injection of pathologic α-synuclein causes PD-like motor and non-motor symptoms•PD-like pathology and symptoms require endogenous α-synuclein

Structure-dependent catalytic properties of mesoporous cobalt oxides in furfural hydrogenation

Highlights•Mesoporous cobalt oxide catalysts are developed for furfural hydrogenation.•CoO is proven to be the most active phase in furfural hydrogenation.•The CoO site induces selective hydrogenation of furfuryl alcohol to methyl furan.•Furfural is adsorbed much strongly on CoO(111) than on Co(111).•Cobalt oxides have low production cost and high efficiency for biomass conversion.

Preparation of pseudo-C2-symmetric P,S-hybrid ferrocenyl ligand and its application to some asymmetric reactions

AbstractA solely planar chiral pseudo-C2-symmetric ferrocene-based P,S-chelating 2 was prepared and applied to some asymmetric reactions. Although a poor enantioselectivity is obtained in the asymmetric allylic alkylation (AAA) of rac-8 using the Pd complex bearing the P,S-hybrid ligand 2, it is noteworthy that this result is superior to that obtained using the C2-symmetric bisphosphine counterpart of 2. The intermolecular asymmetric heck reaction (AHR) of 11 with aryl triflates catalyzed by another palladium complex containing 2 was also carried out. Although both relatively low reactivity and poor enantioselectivity were obtained, a high regioselectivy favoring the 2,5-dihydrofuran derivative (14) over the regioisomeric 2,3-dihydrofuran derivative (15) was observed in this study.

Heparin coating on 3D printed poly (l-lactic acid) biodegradable cardiovascular stent via mild surface modification approach for coronary artery implantation

Highlights•Biodegradable polymeric stent was successfully prepared using 3D printing system.•Heparinization enhances biocompatibility and anti-coagulation activity.•Developed 3D stent showed excellent property in vitro and in vivo.

ReviewSestrins Orchestrate Cellular Metabolism to Attenuate Aging

The Sestrins constitute a family of evolutionarily conserved stress-inducible proteins that suppress oxidative stress and regulate AMP-dependent protein kinase (AMPK)-mammalian target of rapamycin (mTOR) signaling. By virtue of these activities, the Sestrins serve as important regulators of metabolic homeostasis. Accordingly, inactivation of Sestrin genes in invertebrates resulted in diverse metabolic pathologies, including oxidative damage, fat accumulation, mitochondrial dysfunction, and muscle degeneration, that resemble accelerated tissue aging. Likewise, Sestrin deficiencies in mice led to accelerated diabetic progression upon obesity. Further investigation of Sestrin function and regulation should provide new insights into age-associated metabolic diseases, such as diabetes, myopathies, and cancer.

ArticleLiver Damage, Inflammation, and Enhanced Tumorigenesis after Persistent mTORC1 Inhibition

Highlights•mTORC1 inhibition results in STAT3 activation•Raptor ablation results in liver damage, inflammation, and oxidative stress•Raptor ablation potentiates hepatocarcinogenesis in lean and obese mice•Prolonged mTORC1 inhibition results in adverse effects on liver physiology

Full length articleSurface modification of 3D-printed porous scaffolds via mussel-inspired polydopamine and effective immobilization of rhBMP-2 to promote osteogenic differentiation for bone tissue engineering☆

AbstractFor tissue engineering, a bio-porous scaffold which is applied to bone-tissue regeneration should provide the hydrophilicity for cell attachment as well as provide for the capability to bind a bioactive molecule such as a growth factor in order to improve cell differentiation. In this work, we prepared a three-dimensional (3D) printed polycaprolactone scaffold (PCLS) grafted with recombinant human bone morphogenic protein-2 (rhBMP2) attached via polydopamine (DOPA) chemistry. The DOPA coated PCL scaffold was characterized by contact angle, water uptake, and X-ray photoelectron spectroscopy (XPS) in order to certify that the surface was successfully coated with DOPA. In order to test the loading and release of rhBMP2, we examined the release rate for 28 days. For the In vitro cell study, pre-osteoblast MC3T3-E1 cells were seeded onto PCL scaffolds (PCLSs), DOPA coated PCL scaffold (PCLSD), and scaffolds with varying concentrations of rhBMP2 grafted onto the PCLSD 100 and PCLSD 500 (100 and 500 ng/ml loaded), respectively. These scaffolds were evaluated by cell proliferation, alkaline phosphatase activity, and real time polymerase chain reaction with immunochemistry in order to verify their osteogenic activity. Through these studies, we demonstrated that our fabricated scaffolds were well coated with DOPA as well as grafted with rhBMP2 at a quantity of 22.7 ± 5 ng when treatment with 100 ng/ml rhBMP2 and 153.3 ± 2.4 ng when treated with 500 ng/ml rhBMP2. This grafting enables rhBMP2 to be released in a sustained pattern. In the in vitro results, the cell proliferation and an osteoconductivity of PCLSD 500 groups was greater than any other group. All of these results suggest that our manufactured 3D printed porous scaffold would be a useful construct for application to the bone tissue engineering field.Statement of SignificanceTissue-engineered scaffolds are not only extremely complex and cumbersome, but also use organic solvents which can negatively influence cellular function. Thus, a rapid, solvent-free method is necessary to improve scaffold generation. Recently, 3D printing such as a rapid prototyping technique has several benefits in that manufacturing is a simple process using computer aided design and scaffolds can be generated without using solvents. In this study, we designed a bio-active scaffold using a very simple and direct method to manufacture DOPA coated 3D PCL porous scaffold grafted with rhBMP2 as a means to create bone-tissue regenerative scaffolds. To our knowledge, our approach can allow for the generation of scaffolds which possessed good properties for use as bone-tissue scaffolds.

ResourceTED-Seq Identifies the Dynamics of Poly(A) Length during ER Stress

Highlights•TED-seq reveals the regulation of polyadenylation in ER stress response•Poly(A) lengths are increased in ER stress-induced mRNAs•Increased poly(A) lengths are linked to translation and stability in ER stress•mRNAs in stress-induced RNA-granule fraction have shorter poly(A) tails

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