Biography:

In the past D. Clarke has collaborated on articles with J.-Z. Yin and M.G. Albrow. One of their most recent publications is Prevention by a platelet-derived factor (platelet factor 4) of induction of low dose tolerance to pneumococcal polysaccharides☆. Which was published in journal Cellular Immunology.

More information about D. Clarke research including statistics on their citations can be found on their Copernicus Academic profile page.

D. Clarke's Articles: (16)

Prevention by a platelet-derived factor (platelet factor 4) of induction of low dose tolerance to pneumococcal polysaccharides☆

AbstractIt was previously shown that human or mouse serum, and platelet factor 4 (PF4) prepared from human platelet releasate, counteracts nonspecific immunosuppression induced in mice by injection of concanavalin A or syngeneic γ-irradiated lymphoma cells. The present studies show that PF4 prepared from normal mouse or human serum by absorption to heparin-agarose and elution between 0.5 and 1.5 M NaCl is also active in this respect. The ability of PF4 to counteract antigen-specific suppression of the antibody response to pneumococcal polysaccharide (pps) was now studied. PF4 derived from human or mouse serum as well as recombinant PF4 interferes with induction of antigen-specific low dose tolerance when they are injected at the same time as a low dose (0.2 μg) of type 14 pps 3 days before an optimal immunizing dose (25 μg). Furthermore, injection of platelet releasate at the time of an optimal primary immunizing dose of pps type 14 enhances the secondary response to killed bacteria injected 2 weeks later, but not the primary response itself. Both effects are interpreted as due to interference with antigen-specific suppressor cell induction during primary immunization. Injection of PF4 is much less effective in reversing low dose tolerance to an optimal immunizing dose (0.1 μg) of type 3 pps induced by injection of 0.005 μg of this antigen. Differences in the mechanism of tolerance induction for the two pps types that might be responsible for this are discussed.

The solar-stellar connectionThe solar-stellar connection— Polarimetry

AbstractThe status of the solar-stellar connections that can be made through polarimetry is presented by giving brief reviews of the work in the stellar field and of mechanisms that produce polarization in local areas on the Sun. Results are described from novel measurements of the whole solar disk made at the Glasgow Observatory Solar Polarimetric Experimental Laboratory (GOSPEL), these suggesting that the Sun can be considered as being a polarimetric variable star.

A uranium scintillator calorimeter with plastic-fibre readout

AbstractWe have developed a method for reading out scintillator plates in a compact calorimeter using embedded wavelength-shifting fibres coupled to photomultipliers. A test calorimeter using this technique, with uranium plates as the passive medium, was placed in test beams of 1 to 80 GeV. Results on resolution, uniformity, and electron-pion discrimination are presented, as well as a discussion of compensation (the near-equality of electron and hadron responses).

Proton-antiproton states in high energy photoproduction

AbstractExclusive and inclusive pp photoproduction (with ⩾ 2 accompanying charged particles) have been measured in the photon energy range 44–70 GeV. The exclusive process shows no prominent features; the inclusive process shows evidence for S(1936) production as a resonant-like structure with mass 1930 ± 2 MeV and width 12 ± 7 MeV.

Evidence for a high mass enhancement in K+K− photoproduction

AbstractThe reaction γp → K+K− p has been investigated with tagged photons in the energy range of 20 < Eγ < 70 GeV. A structure in the 1.7 GeV mass region is observed and interpreted in terms of a recurrence of the ø.

Experimental investigation of the energy dependence of the strong coupling strength

AbstractThe energy dependence of the relative production rate of three-jet events is studied in hadronic e+e− annihilation events at center of mass energies between 22 and 46.7 GeV. Three-jet events are defined by a jet finding algorithm which is closely related to the definition of resolvable jets used in O(αs2) perturbative QCD calculations, where the relative production rate of three-jet events is roughly proportional to the size of the strong coupling strength. The production rates of three-jet events in the data decrease significantly with increasing centre of mass energy. The experimental rates, which are independent of fragmentation model calculations, can be directly compared to theoretically calculated jet production rates and are in good agreement with the QCD expectations of a running coupling strength. The hypothesis of an energy independent coupling constant can be excluded with a significance of four standard derivations.

Photoproduction of K+K− pairs on hydrogen at photon enegies of 20 to 36 GeV

AbstractThe reaction γp→K+K−p has been investigated with photons in the energy range of 20

Experimental and numerical study of a generic conventional submarine at 10° yaw

Highlights•Experimental study of a generic submarine hull at both straight ahead and at 10° yaw.•Computational (using both RANS and LES) study of a generic submarine hull at both straight ahead and at 10° yaw.•Experimental data and RANS and LES results provide reciprocal validation.•New information about the key flow physics at both straight ahead and at 10° yaw.•Results have strong implications of hull design and maneuvering.

A malariometric survey in Turkana District, Kenya: chemosensitivity in vivo of Plasmodium falciparum infections and identity of the vector

AbstractWe have carried out a limited survey in vivo of the efficacy of chloroquine (n = 39) and pyrimethamine-sulfadoxine (n = 29) as treatments for falciparum malaria in Kaling, Turkana District, northern Kenya. Both treatments were effective, achieving clinical cure (>75% reduction in parasitaemia on day 2 with clinical improvement, and negative blood slide on day 7) in both children and adults. A limited entomological survey suggested that the main malaria vector in this area was Anopheles arabiensis.

Empirical validation of the InVEST water yield ecosystem service model at a national scale

Highlights•Ecosystem service models are widely used but rarely validated with empirical data.•We validated the InVEST water yield model with long-term river flow data in the UK.•We investigated model sensitivity and compared performance with alternative input data.•The model can be highly sensitive to variation or errors in the input parameters.•The InVEST model performed well when national scale input data were used.

GLUCOSE PROMOTES WHOLE-BODY PROTEIN SYNTHESIS FROM INFUSED AMINOACIDS IN FASTING MAN: Isotopic Demonstration

Abstract15N-glycine constant infusion, with plateau urea enrichment as the endpoint, demonstrated a clear increase in whole-body protein synthesis when glucose was added to aminoacid infusion in fasting men. Whole-body protein-breakdown rates remained unchanged. There was an unexpected fall in whole-body nitrogen turnover when the subjects were changed from an oral intake to either of the intravenous programmes: this finding, not previously reported, may be due to the decrease in gastrointestinal enzyme synthesis and intestinal-lining cell-turnover when oral intake is replaced by total parenteral nutrition.

Research sectionEvaluation of chronic oral toxicity and carcinogenic potential of lornoxicam in rats

AbstractAs part of the preclinical development program for lornoxicam, a novel non-steroidal anti-inflammatory drug (NSAID), its chronic oral toxicity and carcinogenic potential was assessed in Sprague-Dawley rats. Male and female rats were administered lornoxicam by oral gavage at 0, 0.06, 0.16 or 0.40 mg/kg/day for 12 months or at 0, 0.01 or 0.06 mg/kg/day in a supplementary low-dose study of the same duration (main group: 20/sex/group; 4-wk recovery: five/sex/group; satellites for electrocardiography and toxicokinetics: five/sex/group). Drug-related toxicity mainly comprised mortality, reduced body weight gain, clinico-pathological changes indicative of anaemia resulting from blood loss, and renal damage, renal papillary necrosis and gastrointestinal mucosal lesions. The kidney-associated changes were not completely reversible during the recovery period. Toxicokinetic investigations demonstrated a dose-linear absorption of the drug. In female rats the terminal half-life was about twice that in males which led to a higher exposure of this gender to lornoxicam. A dose of 0.01 mg/kg/day was established as no-observed-effect level. In a 104-wk carcinogenicity study, lornoxicam was administered by oral gavage to male and female rats (50/sex/group) at 0 (control 1), 0 (control 2), 0.0625, 0.125 or 0.250 mg/ kg/day. In females only, the high dose was reduced twice during the study due to toxicity observed (0.250 to 0.200 to 0.160 mg/kg/day). Drug-related changes were similar to those in the chronic studies and consistent with the anticipated side-effects of NSAIDs. No carcinogenic potential was revealed.

331ISCT survey reponses to process and product development committee's cost-of-goods questionnaire

Background & AimThe ISCT Process and Product Development (PPD) committee conducted a questionnaire regarding Cost of Goods (COG) topics and activities in Cell & Gene therapy in 2017. They survey's questions were around the topics of Product type, Manufacturing, Container, Dose, Storage, Transport, Temperature and Administration.Methods, Results & ConclusionThe ISCT membership was sent the voluntary questionnaire. 51 members filled out the 45-question survey. This poster will release the results and summarize the data from the PPDs COGs questionnaire.A sample of the responses are: respondents were 33% academic vs. private, 93% are working with a therapeutic product, 65% autologous vs. 32% allogenic, T-Cells and MSC represent 68% of cell type used, 54% are seeking US FDA regulation approval and 41% seeking Europe EMEA approval, 31% plan to manufacture at the clinic/hospital, 43% at CMO and 56% internally, 54% plan to use a bag for product delivery and 48% a vial, 44% expect one dose per patient and 31% say it will vary per patient, 56% will store their product at cryogenic temperatures vs 22% fresh, 80% plan to use a DMSO containing cryoprotectant, 34% expect to ship the final product internationally, 74% require thawing of the final product, 56% require a dilution and/or wash, 78% will let the physician determine protocol if any adverse events occur and 50% will offer access to a sponsor review team.The PPD hopes the results of this survey will help further improvements to planning and cost reduction for Cell and Gene therapies.

ReviewHuman behaviours in evacuation crowd dynamics: From modelling to “big data” toward crisis management

Highlights•Human crowds might face stressful evacuation dynamics.•Collective learning and psychology have an important influence on crowd dynamics.•The kinetic theory of active particles provides a unified modelling framework.•Predictive engines contribute to decision making in crisis management.

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