Biography:

In the past Giorgio Biasiotto has collaborated on articles with Claudia Montani. One of their most recent publications is Fibroblasts maintained in 3 dimensions show a better differentiation state and higher sensitivity to estrogens. Which was published in journal Toxicology and Applied Pharmacology.

More information about Giorgio Biasiotto research including statistics on their citations can be found on their Copernicus Academic profile page.

Giorgio Biasiotto's Articles: (2)

Fibroblasts maintained in 3 dimensions show a better differentiation state and higher sensitivity to estrogens

Highlights•We here characterized the first cell line derived from an estrogen reporter mouse.•In the RCCS cells express an immortalized behavior but not a transformed phenotype.•The RCCS provides a system for maintaining cells in more physiological conditions.•RCCS-cultured fibroblasts showed higher hormonal sensitivity to estradiol.•This bioreactor is a novel 3D model to be applied to pharmacotoxicological studies.

Municipal wastewater affects adipose deposition in male mice and increases 3T3-L1 cell differentiation

Highlights•Sewage watewaters (TW) sampled from a Municipal Treatment Sewage Plant are biologically active in mice and in vitro.•In male mice TW promotes an increase in adipose mass deposition following exposure from foetal to adult life. A similar effect is produced by BPA.•The expression of key genes of the adipose metabolism is increased in epidydimal fat both by TW and BPA.•An extract from the TW which concentrated the contained chemicals by a factor of 1000, is able to stimulate 3T3-L1 adipocyte differentiation.•The major chemicals contained in the TW, bisphenol A and nonylphenol, are able to promote adipocyte differentiation at the low environmentally relevant doses as are found in the TW.

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