Biography:

In the past T.A. Doran has collaborated on articles with R.J. Benzie and T.E. Logaridis. One of their most recent publications is Malignant cells in the peripheral blood of patients with endometrial carcinoma☆☆☆. Which was published in journal American Journal of Obstetrics and Gynecology.

More information about T.A. Doran research including statistics on their citations can be found on their Copernicus Academic profile page.

T.A. Doran's Articles: (31)

Malignant cells in the peripheral blood of patients with endometrial carcinoma☆☆☆

AbstractNinety-one patients with adenocarcinoma of the endometrium were studied for the presence of suspicious cells in the bloodstream during treatment. Thirteen per cent of the samples in the cancer group were found to have suspicious cells as compared with a 3 per cent incidence in 139 control patients. No correlation was found with the stage of the disease, but there did seem to be a correlation with the differentiation of the tumor. The prognostic significance of the finding of these abnormal cells in the bloodstream in these patients must await long-term follow-up.

Transactions of the Twenty-fifth Annual Meeting of the Society of Obstetricians and Gynaecologists of CanadaCreatinine, uric acid, and electrolytes in amniotic fluid☆

AbstractFour hundred samples of amniotic fluid obtained by amniocentesis, mostly from Rh-sensitized patients, were analyzed for creatinine, uric acid, sodium, potassium, and chloride. Amniotic fluid creatinine values were below 1 mg. per 100 ml. before 28 weeks and about 2 mg. per 100 ml. close to term. Eighty-six per cent of all creatinine values at 37 weeks' gestation or more were at or above 1.6 mg. per 100 ml. Serial creatinine values in stillbirths were generally low and showed a decline. There was good correlation between creatinine values and both birth weight and maturity of infants born within one week of amniocentesis. Amniotic fluid uric acid increased with gestational age with a fairly wide scatter. Values for sodium and chloride stayed approximately in the range of those for normal serum with a slight progressive fall to term. Potassium values stayed within normal serum values but showed a slight rise to term. Amniotic fluid creatinine showed the most definite trend with gestational age and thus is a useful test for fetal maturity.

Composition of the amniotic fluid and maternal serum in pregnancy☆

AbstractThe following parameters in maternal serum and amniotic fluid were simultaneously estimated at varying periods of gestation by manual and automated techniques in 252 samples: bilirubin, sodium, potassium, chloride, total CO2, urea nitrogen, glucose, uric acid, creatinine, total protein, albumin, osmolality, alkaline phosphatase, acid phosphatase, lactic dehydrogenase, hydroxybutyric dehydrogenase, and creatine kinase. Analysis of the results established norms for several parameters and indicated areas of difference from results of other workers. Emphasis is placed on the need for further biochemical studies of this nature.

Amniotic fluid tests for fetal maturity☆

AbstractEighteen biochemical parameters and one cytologic test (percentage of lipid-positive cells) in amniotic fluid were assessed for their value in establishing fetal maturity. Ten parameters showed a trend with gestation but the three best tests were percentage of lipid-positive cells, lecithin/sphingomyelin ratio (L/S), and creatinine. With the use of a graph containing the mean value of the three key parameters, an estimated period of gestation was produced which was 95 per cent accurate for any individual sample. With some minor deviations the three tests and the estimated period of gestation based on the three tests continued to be accurate in abnormal pregnancy states.

The effect of maternal steroid administration on fetal platelet count in immunologic thrombocytopenic purpura: Management of pregnancy and mode of delivery

AbstractEight pregnancies complicated by immunologic thrombocytopenic purpura are described and the literature is reviewed. We conclude that, while steroid treatment favorably influenced fetal platelet counts in our cases, overall experience with this disease indicates that such protection is incomplete in some cases and unnecessary in others. Antiplatelet antibody levels show promise as excellent indicators of fetal thrombocytopenia, and elevated levels may be an indication for steroid therapy for the improvement of fetal well-being in some cases.

Genetic amniocentesis in seventy twin pregnancies☆

AbstractGenetic amniocenteses were performed in 70 twin pregnancies over an 11-year period. Both sacs were successfully sampled in 49 of 62 patients (79%). The success rate was decreased (68%) with two placentas (anterior and posterior) and was improved with gestational age ≥17 weeks (88%) and with ultrasound visualization of the septum (86%). Of three spontaneous abortions, two were attributed to amniocentesis (chorioamnionitis). When twin pregnancy is diagnosed in a patient with an indication for genetic amniocentesis, a careful reevaluation and discussion of risk factors with the couple are recommended.

Malignant cells in the peripheral blood of patients with endometrial carcinoma☆☆☆

AbstractNinety-one patients with adenocarcinoma of the endometrium were studied for the presence of suspicious cells in the bloodstream during treatment. Thirteen per cent of the samples in the cancer group were found to have suspicious cells as compared with a 3 per cent incidence in 139 control patients. No correlation was found with the stage of the disease, but there did seem to be a correlation with the differentiation of the tumor. The prognostic significance of the finding of these abnormal cells in the bloodstream in these patients must await long-term follow-up.

Transactions of the Twenty-fifth Annual Meeting of the Society of Obstetricians and Gynaecologists of CanadaCreatinine, uric acid, and electrolytes in amniotic fluid☆

AbstractFour hundred samples of amniotic fluid obtained by amniocentesis, mostly from Rh-sensitized patients, were analyzed for creatinine, uric acid, sodium, potassium, and chloride. Amniotic fluid creatinine values were below 1 mg. per 100 ml. before 28 weeks and about 2 mg. per 100 ml. close to term. Eighty-six per cent of all creatinine values at 37 weeks' gestation or more were at or above 1.6 mg. per 100 ml. Serial creatinine values in stillbirths were generally low and showed a decline. There was good correlation between creatinine values and both birth weight and maturity of infants born within one week of amniocentesis. Amniotic fluid uric acid increased with gestational age with a fairly wide scatter. Values for sodium and chloride stayed approximately in the range of those for normal serum with a slight progressive fall to term. Potassium values stayed within normal serum values but showed a slight rise to term. Amniotic fluid creatinine showed the most definite trend with gestational age and thus is a useful test for fetal maturity.

Composition of the amniotic fluid and maternal serum in pregnancy☆

AbstractThe following parameters in maternal serum and amniotic fluid were simultaneously estimated at varying periods of gestation by manual and automated techniques in 252 samples: bilirubin, sodium, potassium, chloride, total CO2, urea nitrogen, glucose, uric acid, creatinine, total protein, albumin, osmolality, alkaline phosphatase, acid phosphatase, lactic dehydrogenase, hydroxybutyric dehydrogenase, and creatine kinase. Analysis of the results established norms for several parameters and indicated areas of difference from results of other workers. Emphasis is placed on the need for further biochemical studies of this nature.

Amniotic fluid tests for fetal maturity☆

AbstractEighteen biochemical parameters and one cytologic test (percentage of lipid-positive cells) in amniotic fluid were assessed for their value in establishing fetal maturity. Ten parameters showed a trend with gestation but the three best tests were percentage of lipid-positive cells, lecithin/sphingomyelin ratio (L/S), and creatinine. With the use of a graph containing the mean value of the three key parameters, an estimated period of gestation was produced which was 95 per cent accurate for any individual sample. With some minor deviations the three tests and the estimated period of gestation based on the three tests continued to be accurate in abnormal pregnancy states.

The effect of maternal steroid administration on fetal platelet count in immunologic thrombocytopenic purpura: Management of pregnancy and mode of delivery

AbstractEight pregnancies complicated by immunologic thrombocytopenic purpura are described and the literature is reviewed. We conclude that, while steroid treatment favorably influenced fetal platelet counts in our cases, overall experience with this disease indicates that such protection is incomplete in some cases and unnecessary in others. Antiplatelet antibody levels show promise as excellent indicators of fetal thrombocytopenia, and elevated levels may be an indication for steroid therapy for the improvement of fetal well-being in some cases.

Genetic amniocentesis in seventy twin pregnancies☆

AbstractGenetic amniocenteses were performed in 70 twin pregnancies over an 11-year period. Both sacs were successfully sampled in 49 of 62 patients (79%). The success rate was decreased (68%) with two placentas (anterior and posterior) and was improved with gestational age ≥17 weeks (88%) and with ultrasound visualization of the septum (86%). Of three spontaneous abortions, two were attributed to amniocentesis (chorioamnionitis). When twin pregnancy is diagnosed in a patient with an indication for genetic amniocentesis, a careful reevaluation and discussion of risk factors with the couple are recommended.

Malignant cells in the peripheral blood of patients with endometrial carcinoma☆☆☆

AbstractNinety-one patients with adenocarcinoma of the endometrium were studied for the presence of suspicious cells in the bloodstream during treatment. Thirteen per cent of the samples in the cancer group were found to have suspicious cells as compared with a 3 per cent incidence in 139 control patients. No correlation was found with the stage of the disease, but there did seem to be a correlation with the differentiation of the tumor. The prognostic significance of the finding of these abnormal cells in the bloodstream in these patients must await long-term follow-up.

Transactions of the Twenty-fifth Annual Meeting of the Society of Obstetricians and Gynaecologists of CanadaCreatinine, uric acid, and electrolytes in amniotic fluid☆

AbstractFour hundred samples of amniotic fluid obtained by amniocentesis, mostly from Rh-sensitized patients, were analyzed for creatinine, uric acid, sodium, potassium, and chloride. Amniotic fluid creatinine values were below 1 mg. per 100 ml. before 28 weeks and about 2 mg. per 100 ml. close to term. Eighty-six per cent of all creatinine values at 37 weeks' gestation or more were at or above 1.6 mg. per 100 ml. Serial creatinine values in stillbirths were generally low and showed a decline. There was good correlation between creatinine values and both birth weight and maturity of infants born within one week of amniocentesis. Amniotic fluid uric acid increased with gestational age with a fairly wide scatter. Values for sodium and chloride stayed approximately in the range of those for normal serum with a slight progressive fall to term. Potassium values stayed within normal serum values but showed a slight rise to term. Amniotic fluid creatinine showed the most definite trend with gestational age and thus is a useful test for fetal maturity.

Composition of the amniotic fluid and maternal serum in pregnancy☆

AbstractThe following parameters in maternal serum and amniotic fluid were simultaneously estimated at varying periods of gestation by manual and automated techniques in 252 samples: bilirubin, sodium, potassium, chloride, total CO2, urea nitrogen, glucose, uric acid, creatinine, total protein, albumin, osmolality, alkaline phosphatase, acid phosphatase, lactic dehydrogenase, hydroxybutyric dehydrogenase, and creatine kinase. Analysis of the results established norms for several parameters and indicated areas of difference from results of other workers. Emphasis is placed on the need for further biochemical studies of this nature.

Amniotic fluid tests for fetal maturity☆

AbstractEighteen biochemical parameters and one cytologic test (percentage of lipid-positive cells) in amniotic fluid were assessed for their value in establishing fetal maturity. Ten parameters showed a trend with gestation but the three best tests were percentage of lipid-positive cells, lecithin/sphingomyelin ratio (L/S), and creatinine. With the use of a graph containing the mean value of the three key parameters, an estimated period of gestation was produced which was 95 per cent accurate for any individual sample. With some minor deviations the three tests and the estimated period of gestation based on the three tests continued to be accurate in abnormal pregnancy states.

The effect of maternal steroid administration on fetal platelet count in immunologic thrombocytopenic purpura: Management of pregnancy and mode of delivery

AbstractEight pregnancies complicated by immunologic thrombocytopenic purpura are described and the literature is reviewed. We conclude that, while steroid treatment favorably influenced fetal platelet counts in our cases, overall experience with this disease indicates that such protection is incomplete in some cases and unnecessary in others. Antiplatelet antibody levels show promise as excellent indicators of fetal thrombocytopenia, and elevated levels may be an indication for steroid therapy for the improvement of fetal well-being in some cases.

Genetic amniocentesis in seventy twin pregnancies☆

AbstractGenetic amniocenteses were performed in 70 twin pregnancies over an 11-year period. Both sacs were successfully sampled in 49 of 62 patients (79%). The success rate was decreased (68%) with two placentas (anterior and posterior) and was improved with gestational age ≥17 weeks (88%) and with ultrasound visualization of the septum (86%). Of three spontaneous abortions, two were attributed to amniocentesis (chorioamnionitis). When twin pregnancy is diagnosed in a patient with an indication for genetic amniocentesis, a careful reevaluation and discussion of risk factors with the couple are recommended.

Malignant cells in the peripheral blood of patients with endometrial carcinoma☆☆☆

AbstractNinety-one patients with adenocarcinoma of the endometrium were studied for the presence of suspicious cells in the bloodstream during treatment. Thirteen per cent of the samples in the cancer group were found to have suspicious cells as compared with a 3 per cent incidence in 139 control patients. No correlation was found with the stage of the disease, but there did seem to be a correlation with the differentiation of the tumor. The prognostic significance of the finding of these abnormal cells in the bloodstream in these patients must await long-term follow-up.

Transactions of the Twenty-fifth Annual Meeting of the Society of Obstetricians and Gynaecologists of CanadaCreatinine, uric acid, and electrolytes in amniotic fluid☆

AbstractFour hundred samples of amniotic fluid obtained by amniocentesis, mostly from Rh-sensitized patients, were analyzed for creatinine, uric acid, sodium, potassium, and chloride. Amniotic fluid creatinine values were below 1 mg. per 100 ml. before 28 weeks and about 2 mg. per 100 ml. close to term. Eighty-six per cent of all creatinine values at 37 weeks' gestation or more were at or above 1.6 mg. per 100 ml. Serial creatinine values in stillbirths were generally low and showed a decline. There was good correlation between creatinine values and both birth weight and maturity of infants born within one week of amniocentesis. Amniotic fluid uric acid increased with gestational age with a fairly wide scatter. Values for sodium and chloride stayed approximately in the range of those for normal serum with a slight progressive fall to term. Potassium values stayed within normal serum values but showed a slight rise to term. Amniotic fluid creatinine showed the most definite trend with gestational age and thus is a useful test for fetal maturity.

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