Biography:

In the past John R. Richert has collaborated on articles with Russel J. Reiter. One of their most recent publications is Failure of serum from recovered rats to prevent enhanced adoptive transfer of experimental allergic encephalomyelitis☆. Which was published in journal Journal of the Neurological Sciences.

More information about John R. Richert research including statistics on their citations can be found on their Copernicus Academic profile page.

John R. Richert's Articles: (3)

Failure of serum from recovered rats to prevent enhanced adoptive transfer of experimental allergic encephalomyelitis☆

AbstractThe rat is unique among species used for research on experimental allergic encephalomyelitis (EAE) because of the spontaneous recovery which occurs routinely after severe, almost fatal disease. The mechanism of recovery has never been adequately explained although it has been suggested that suppressor cells might play a role in this phenomenon. In another immune system (contact sensitivity) anti-idiotypic antibodies obtained during the recovery phase have been shown to have a protective effect. Adoptive transfer of EAE, which can be markedly enhanced by incubation of sensitized cells with antigen in vitro, offers a convenient tool for investigating mechanisms of recovery. With this system, we have attempted to suppress transfer of disease with serum obtained from recovered rats. In spite of various manipulations of the experimental protocol, including the use of serum plus complement before and after incubation of cells with antigen, we have been unable to demonstrate suppression of disease. We and others recently reported that cells from recovered rats are also capable of enhanced transfer. This permitted the use of autologous serum from individual cell donors. Even in this strictly autologous system, however, no inhibitory effect of serum could be detected.

Pineal-induced ovarian atrophy in rats treated neonatally with testosterone☆

AbstractBlinding 2 or 3 day old rats decreased uterine weights when animals were killed at 75 days of age; the effect of blinding was counteracted by pinealectomy. TP-treatment at 3 days of age reduced ovarian, but not uterine, size at 75 days of age. This decrease was not prevented by pinealectomy. The combination of blinding and TP-treatment caused marked reductions in the size of both the ovaries and uteri; if these rats were pinealectomized the ovaries and uteri returned to the levels of similar organs in TP-treated animals.

Expansion of antigen-specific T cells from cerebrospinal fluid of patients with multiple sclerosis☆

AbstractWe have expanded cerebrospinal fluid (CSF) T lymphocytes obtained from four patients with multiple sclerosis (MS). Fresh CSF cells were placed into culture with medium, interleukin-2, irradiated autologous peripheral blood mononuclear cells, and either myelin basic protein (BP) or measles virus antigen. Two CSF cell lines demonstrated a mild degree of antigen-specific proliferation to BP, a third reacted with measles virus, and the fourth demonstrated no known antigenic specificity. The percentage of HLA-DR + cells was increased in all four cell lines. The culture procedure has thus selected for a population of activated T cells, some of which demonstrate reactivity with antigens of potential relevance to the pathogenesis of MS.

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