Biography:

In the past Leigh C.P. Botly has collaborated on articles with Derya Sargin. One of their most recent publications is The nucleus basalis magnocellularis contributes to feature binding in the rat. Which was published in journal Physiology & Behavior.

More information about Leigh C.P. Botly research including statistics on their citations can be found on their Copernicus Academic profile page.

Leigh C.P. Botly's Articles: (2)

The nucleus basalis magnocellularis contributes to feature binding in the rat

AbstractThe binding problem refers to the fundamental challenge of the central nervous system to integrate sensory information registered by multiple brain regions to form a unified neural representation of a stimulus. Although the human cognitive literature has yielded substantial insights into the attention-dependent nature and general cortical networks involved in feature binding, the specific downstream neuroanatomical modulatory contributions to feature binding remain unknown. We hypothesized that the nucleus basalis magnocellularis (NBM) of the basal forebrain would be critical for feature binding given the NBM's widespread neuromodulatory projections to regions of the neocortex important for attentional processing, such as the frontal and parietal cortices. Accordingly, we tested the ability of rats with bilateral excitotoxic (quisqualic acid) lesions of the NBM to acquire a crossmodal Feature-Conjunction (FC) task that required feature binding and a Feature-Singleton (FS) task that did not require feature binding. Additionally, rats retrieved a FC stimulus set they had acquired prior to surgery. Relative to sham-lesioned controls, NBM-lesioned rats were significantly impaired at acquiring and retrieving the FC task, while their ability to acquire the FS task remained intact. These findings provide insight into the functional role of the NBM and establish the importance of this basal forebrain structure to the fundamental cognitive process of feature binding.

Disrupting Jagged1–Notch signaling impairs spatial memory formation in adult mice

Highlights•Notch signaling is important in brain development and implicated in adult synaptic plasticity and memory.•Roles of Notch ligands (e.g., Delta-like, Dll1, Jagged, Jag1), modulators (Lunatic fringe, Lfng) in memory are unknown.•We examined memory and other behaviors in adult mice with reduced expression of Dll1, Jag1, Lfng and Dll1 + Lfng.•Mice with reduced Jag1 expression showed impaired spatial memory formation but normal behavior in all other tests.•These results provide the first in vivo evidence that Jag1–Notch signaling is critical for memory formation in adults.

Advertisement
Join Copernicus Academic and get access to over 12 million papers authored by 7+ million academics.
Join for free!

Contact us