Biography:

In the past Zheng Li has collaborated on articles with Neil M. Montgomery and Chengchuan Zhou. One of their most recent publications is Anatomical evidence for an intergeniculate leaflet in Rana pipiens. Which was published in journal Neuroscience Letters.

More information about Zheng Li research including statistics on their citations can be found on their Copernicus Academic profile page.

Zheng Li's Articles: (189)

Anatomical evidence for an intergeniculate leaflet in Rana pipiens

AbstractThe projections of the nucleus of Bellonci and the anterior thalamic nucleus in Rana pipiens appear to be remarkably similar to those that have been described for the mammalian intergeniculate leaflet. The connections of these nuclei were examined using both the anterograde and retrograde transport of horseradish peroxidase. Afferents to the neuropil of Bellonci and its nucleus include bilateral projections from the retina, the contralateral nucleus of Bellonci, and anterior thalamic nucleus as well as bilateral projections from the pretectum and the ipsilateral suprachiasmatic nucleus. Efferent projections observed following HRP injections in the anterior thalamus consist of three components: (1) a ventral hypothalamic-suprachiasmatic and commissural projection, (2) a dorsal descending tract to the pretectum and tectum, and (3) a ventral descending tract to the somatomotor brainstem.

Segregation of optic axons based on central target: the medial optic tract in Rana pipiens

AbstractThe retinofugal projection to the nucleus of Bellonci (nB) was examined in Rana pipiens using both anterograde and retrograde transport of horseradish peroxidase (HRP). Following HRP injection into the nB, retrogradely labeled optic axons formed a discrete fascicle that crossed the lateral margin of the anterior diencephalon. We have designated this branch of the retinofugal pathway as the “medial optic tract.” HRP-positive, medial optic tract axons projecting to nB occupied the rostral and most dorsal portion of the optic chiasm. The present findings indicate that within the optic chiasm, retinal axons are sorted according to their final destinations.

Modeling and simulation of charge collection properties for neutron irradiated silicon detectors☆

AbstractCharge collection deficiencies for neutron irradiated silicon p+/n/n+ junction detectors are calculated from the interaction between the free carriers generated by particles to be detected and traps created by neutron radiation. The current induced on collection electrode as a function of time by free carriers moving in the detector electrical field is presented. Alpha (α) particle and minimum ionization particle (MIP) induced current shapes were simulated in various electrical field conditions including the reversal of the field in the case of “type inversion”. The simulation based on α-particle data predicts that the charge collection deficiency of MIP for neutron damaged detector with the thickness of 350 μm after 1×1014n/cm2 would be less than 20% when operated at a bias of 260 volts.

Regional analysis of cloud chemistry at high elevations in the eastern United States

AbstractResults from the collection and chemical analysis of cloudwater samples collected from May to October 1986–1988 from the five high-elevation (⪆950 m MSL) Mountain Cloud Chemistry Program (MCCP) sites (Whiteface Mountain, NY; Mt Moosilauke, NH; Shenandoah Park, VA; Whitetop Mountain, VA; Mt Mitchell, NC) in the eastern United States are summarized. The resulting database documents the regional chemical climatology of high-elevation forest ecosystems in the eastern U.S. Clouds occured at these sites on 32–77% of the days during the sample collection period. More than 90% of cloud samples were acidic (prmpH<5.0). The lowest cloudwater pH (2.29 integrated 1-h collection period) was recorded at Mt Mitchell, NC. At all sites sulfate and nitrate were the dominant anions and hydrogen and ammonium were the dominant cations in cloudwater samples. Mount Mitchell received the most acidic clouds and highest chemical exposures, while the Whiteface summit site received the least acidic and lowest chemical exposures compared to other MCCP high-elevation sites. Cloud pH and major chemical components exhibited a seasonal trend with the maxima during the summer months, and correlated well with temperature and ozone concentrations. The mean equivalent ratios of SO42− to NO3− were found to be 1.9–3.9 at these sites. It is noted that SO42− correlated highly with hydrogen ion, suggesting that contribution to cloud acidity by sulfate and/or its precursors may be significant.

A Superstructure Based Mixed-integer Programming Approach to the Optimal Design of a Pipelines Network for CO2 Transport

AbstractCO2 capture and sequestration (CCS) is a major means to reduce greenhouse gas emissions, especially from centralized energy conversion sites. Many studies have been conducted either on the CO2 capture side or on the sequestration side, but research on CO2 transport, which connects the capture side and the sequestration side, is rather limited. CO2 capture sites and sequestration sites are usually not geographically located in the same region, thus planning and design of CO2 transport infrastructure must be considered before capture and sequestration activities are conducted. Previously, some studies have been conducted to address the optimal planning problem of CO2 pipelines network via a source-sink match approach, which is applicable to early stages of CCS development when the total amount of CO needed to be transported is rather small. However, in scenarios with large amount of CO to be transported, the source-sink match approach appears to be less efficient. In this manuscript, we propose a superstructure based modelling and optimization framework for optimal planning of CO2 transport pipelines network, where all CO2 emissions sources and sequestrations sites can be connected by pipelines, and pump stations can also be built along pipelines to maintain the pressure of CO transported. We also provide a case study of a region in North China, with 45 emissions sources and four sequestration sites. Different configurations of pipelines network are illustrated in scenarios with low, medium, and high CO2 capture rates.

A low-carbon power generation pathway for China: Scenario analysis with carbon pricing mechanism

AbstractChina has made a commitment to reach its greenhouse gas emissions peak around 2030. This poses great challenge and uncertainty to the development of its power sector. Power supply and demand in China has already exhibited a feature of uneven spatial distribution, and this may be largely exaggerated if some constraint on greenhouse gas emissions is set on the sector. In this paper, we propose scenario analyses of China’s power sector with carbon pricing mechanism based on a multi-regional and multi-period power sector planning model. The optimal installed capacity for power generation technologies and CO2 emissions in different regions are illustrated.

Paper-based chemiluminescence enzyme-linked immunosorbent assay enhanced by biotin-streptavidin system for high-sensitivity C-reactive protein detection

Highlights•A chemiluminescence p-ELISA for detection of hs-CRP with the LOD of 0.49 ng mL−1.•Biotin-streptavidin system has been employed to improve the sensitivity of the assay.•Detection with less sample volume (4 μL) in shorter period of time (less than 30 min).•This assay has successfully detected hs-CRP in clinical serum samples.

Transcription factor E93 regulates wing development by directly promoting Dpp signaling in Drosophila

Highlights•Wing-specific knockdown of the E93 gene in Drosophila impedes wing development.•The Dpp gene is identified as a novel target of Drosophila E93.•E93 promotes Dpp signaling during Drosophila wing development.

Circular RNA circ_0020123 promotes non-small cell lung cancer progression by acting as a ceRNA for miR-488–3p to regulate ADAM9 expression

Highlights•Circ_0020123 is elevated in NSCLC samples and cells and correlates with unfavorable prognosis.•Circ_0020123 executes oncogenic properties in NSCLC cells.•Circ_0020123 could sponge miR-182 to elevate ADAM9 expression.•Circ_0020123 regulates cell growth, apoptosis and invasion partly through ADAM9.

Novel fatty chain-modified glucagon-like peptide-1 conjugates with enhanced stability and prolonged in vivo activity

AbstractA series of fatty chain conjugates of glucagon-like peptide-1(GLP-1) were designed and synthesized. First, eleven cysteine modified peptides (1–11) were prepared using Gly8-GLP-1(7-36)-NH2 peptide as a starting point. Peptides 1, 6, 9, and 11 which showed comparable GLP-1 receptor activate potency and glucose-lowering effect in vivo with Gly8-GLP-1(7-36)-NH2 were selected for second step modifications to yield conjugates 12–23. All conjugates retained significant GLP-1 receptor activate potency and more importantly exerted enhanced albumin-binding properties and in vitro plasma stability. The protracted antidiabetic effects of the most stable compound 14 were further confirmed by both multiple intraperitoneal glucose tolerance test and hypoglycemic efficacies test in vivo. Furthermore, once daily injection of compound 14 to db/db mice achieved long-term beneficial effects on HbA1c lowering and glucose tolerance. Our results suggest that compound 14 is a promising type 2 antidiabetic agent deserving further investigation.

Evolution of the nanostructure, fractal dimension and size of in-cylinder soot during diesel combustion process

AbstractThe nanostructure, fractal dimension and size of in-cylinder soot during diesel combustion process have been investigated for a heavy-duty direct injection diesel engine, using a total cylinder sampling system followed by high-resolution transmission electron microscopy and Raman scattering spectrometry. Different structural organizations of in-cylinder soot are found depending upon the combustion phase. It is revealed that both the fringe tortuosity and separation distance decrease as combustion proceeds, while the mean fringe length increases distinctly from 1.00 to 2.13 nm, indicating the soot evolution toward a more graphitic structure during the combustion process. The fractal dimensions of aggregates are in a range of 1.20–1.74 at various crank angles under the applied engine operating conditions. As temperature and pressure increase, the fractal dimension decreases significantly to a minimum at the early diffusion combustion stage. The soot particles become more compact again as the fractal dimension increases during the subsequent combustion period. Primary particle sizes start small, go through a maximum in the early diffusion combustion phase and decline again as combustion proceeds.

Repeatedly high polycyclic aromatic hydrocarbon exposure and cockroach sensitization among inner-city children

Highlights•PAH metabolite levels in our cohort are substantially higher than US national reference values.•Repeated high PAH exposure may increase the risk of developing cockroach sensitization.•Early childhood and preadolescent period are important time windows of exposure for cockroach sensitization.

Full length articleLncRNA LINC00319 is associated with tumorigenesis and poor prognosis in glioma

AbstractGlioma is one of the most universally diagnosed malignant tumors in the central nervous system with high mortality and morbidity in the world. Long non-coding long intergenic non-protein coding RNA 319 (LINC00319) exerts promoting function in diverse range of human carcinomas, but its detailed role in glioma remains to be investigated. This study aimed to investigate the potential role and regulatory mechanism of LINC00319 and also its clinical value in glioma. In our study, LINC00319 was expressed at high levels in glioma and closely associated with poor prognosis of patients with glioma, whose knockdown impaired cell proliferation, arrested cell cycle and induced cell apoptosis of glioma. In addition, high expression of high mobility group AT-hook 2 (HMGA2) was found in glioma which was also in positive relation to LINC00319 expression. Moreover, LINC00319 directly bound to TATA-box binding protein associated factor 1 (TAF1) and further regulated HMGA2. Finally, rescue assays verified that LIN00319 modulated the tumorigenesis of glioma by regulating HMGA2. The present research elucidated the function role and underlying mechanism of LINC00319 in glioma and exposed a new insight into the molecular-targeted therapy for glioma.

Allyl phenolic-phthalonitrile resins with tunable properties: Curing, processability and thermal stability

Highlights•Allyl phenolic and phthalonitrile was combined together for the first time.•The correlation between allylation degree and concerned properties was established.•The allyl moieties provide more functionalized choice for phthalonitrile resins.•Šesták-Berggren model was applied to study the curing kinetics of phthalonitrile.

Original articleReal-time Raman microspectroscopy scanning of the single live sperm bound to human zona pellucida

ObjectiveTo determine if Raman microspectroscopy (RMS) can distinguish sperm bound to the human zona pellucida (ZP) from those unbound sperm.DesignPaired experiments to compare Raman scanning features of ZP-bound and unbound sperm.SettingPublic hospital–based clinical assisted reproduction center.Patient(s)Sperm samples from ten fertile donors were used in this study.Intervention(s)None.Main Outcome Measure(s)Sperm-ZP binding, ZP-induced acrosome reaction, and scanning intensity of various regions of sperm.Result(s)The RMS found two slightly low-intensity regions (800–900 and 3,200–4,000 cm−1) shifted to high-intensity grade at the acrosome region of the ZP-bound sperm compared with unbound sperm. Moreover, principal component analysis and statistical analysis showed that the RMS can distinguish the ZP-bound sperm from the unbound sperm.Conclusion(s)RMS scanning of single live sperm could be used to distinguish ZP-bound sperm from unbound sperm. Thus, RMS may be a useful tool to detect normal functional sperm and to select sperm for intracytoplasmic sperm injection.

Original articleRaman spectroscopy as an ex vivo noninvasive approach to distinguish complete and incomplete spermatogenesis within human seminiferous tubules

ObjectiveTo evaluate the potential clinical application of Raman spectroscopy (RS) as a tool that may identify spermatogenesis within human seminiferous tubules.DesignRS scanning of human testicular tissue at different maturational stages; immunohistochemistry study and metabolomic analysis of nonobstructive azoospermic/obstructive azoospermic testes.SettingState-owned hospital.Patient(s)Fifty-two patients with clinical indications of nonobstructive azoospermia (NOA) and obstructive azoospermia (OA) who underwent infertility evaluation and treatment.Intervention(s)None.Main Outcome Measurement(s)Raman spectra of seminiferous tubules, thickness of lamina propria (LP), immunohistochemistry of type I, III, and IV collagens and laminin, metabolites of human testes.Result(s)Tubules of OA patients had spectral intensities below 2,000 (au), while tubules of NOA patients had higher intensities, depending on the degree of spermatogenesis. RS was able to separate samples of NOA and OA testicular tissue with a sensitivity of 90% and specificity of 85.71%. The LP of NOA tubules were thickened and had increased deposition of type I and type III collagens. Gas chromatography-mass spectrometer (GC-MS) detected 12 metabolites that showed significant differences between NOA and OA testes.Conclusion(s)RS can noninvasively distinguish seminiferous tubules with complete and incomplete spermatogenesis and may serve as a novel and potentially useful tool to guide surgeons performing micro-testicular sperm extraction to improve sperm retrieval.

Generalized predictive control of linear time-varying systems

AbstractWe study the problem of predictive control of linear time-varying systems and develop a generalized predictive controller for optimal control of a standard single-input single-output controlled autoregressive moving average model. Linear time-varying output filtering and incremental of control is included for flexibility for applications. The controller is applicable to a large class of linear time-varying systems.

Performance evaluation of methane separation from coal mine gas by gas hydrate formation in a stirred reactor and in a fixed bed of silica sand

Highlights•CH4 separation from the coal mine gas was carried out by gas hydrate formation.•Stirred reactor performed better than the silica sand bed for CH4 recovery.•CH4 recovery was greatly promoted by adding SDS in THF solutions.

Full Length ArticleInteractions during co-pyrolysis of direct coal liquefaction residue with lignite and the kinetic analysis

Highlights•Positive and negative interactions are co-existing during co-pyrolysis of DCLR with lignite.•HS and A in DCLR promote the release of volatiles at low temperatures during co-pyrolysis.•The pyrolysis reactivity of co-pyrolysis samples increases with the increase of DCLR fraction.

Full Length ArticleAccumulation behaviors of methane in the aqueous environment with organic matters

Highlights•Shale gas can accumulate at the organic matter-water interface spontaneously.•The shale gas accumulation phenomenon is independent on the gas saturation.•Wall- and water-gas interactions facilitate the shale gas accumulation.•Gas-gas interactions impede the shale gas accumulation.•Temperature and wettability affect the accumulation greatly but pressure doesn’t.

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