Biography:

In the past Ming Zeng has collaborated on articles with Lina Zhang and Huan Wang. One of their most recent publications is Chapter 23 - Proteins as Sources of Materials. Which was published in journal .

More information about Ming Zeng research including statistics on their citations can be found on their Copernicus Academic profile page.

Ming Zeng's Articles: (40)

Chapter 23 - Proteins as Sources of Materials

Publisher SummaryProteins are natural, renewable, and biodegradable polymers which have attracted considerable attention in recent years in terms of advances in genetic engineering, eco-friendly materials, and novel composite materials based on renewable sources. This chapter reviews the protein structures, their physicochemical properties, their modification and their application, with particular emphasis on soy protein, zein, wheat protein, and casein. First, it presents an overview of the structure, classification, hydration–dehydration, solubility, denaturation, and new concepts on proteins. Second, it concentrates on the physical and chemical properties of the four important kinds of proteins. Third, the potential applications of proteins, including films and sheets, adhesives, plastics, blends, and composites are discussed.

CGK733 enhances multinucleated cell formation and cytotoxicity induced by taxol in Chk1-deficient HBV-positive hepatocellular carcinoma cells

AbstractHepatocellular carcinoma (HCC) is one of the most deadly human cancers. Chronic hepatitis B virus (HBV) infection is one of the predominant risk factors associated with the development of HCC and complicates the treatment of HCC. In this study, we demonstrate that a HBV-positive HCC cell line HepG2.2.15, was more resistant to chemotherapy agents than its parental HBV-negative cell line HepG2. HBV-positive HCC cells exhibited defective Chk1 phosphorylation and increased chromosomal instability. CGK733, a small molecule inhibitor reportedly targeting the kinase activities of ATM and ATR, significantly enhanced taxol-induced cytotoxicity in HBV-positive HepG2.2.15 cells. The mechanism lies in CGK733 triggers the formation of multinucleated cells thus promotes the premature mitotic exit of taxol-induced mitotic-damaged cells through multinucleation and mitotic catastrophe in HBV-positive HepG2.2.15 cells. These results suggest that CGK733 could potentially reverse the taxol resistance in HBV-positive HCC cells and may suggest a novel strategy to treat HBV-infected HCC patients.

Stochastic Burgers' equation driven by fractional Brownian motion

AbstractIn this paper, we consider the stochastic Burgers' equation driven by a genuine cylindrical fractional Brownian motion with Hurst parameter H>14. We first prove the regularities of the solution to the linear stochastic problem corresponding to the stochastic Burgers' equation. Then we obtain the local and global existence and uniqueness results for the stochastic Burgers' equation.

Effects of solid substrate on structure and properties of casting waterborne polyurethane/carboxymethylchitin films

AbstractWe prepared two series of semiinterpenetrating polymer network (semi-IPN) films from cross-linked waterborne polyurethane (WPU) and carboxymethylchitin (CMCH) in the aqueous solution on the glass and Teflon as the hydrophilic and hydrophobic substrates, respectively, by casting method. The chemical compositions, structure and morphologies of the films were examined by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and scanning electron microscopy (SEM). The miscibility, thermal stability and mechanical properties of the films were investigated by density measurement, dynamic mechanical analysis (DMA), ultraviolet (UV) spectroscopy, thermogravimetric analysis (TGA), tensile testing and solvent swelling testing. The results revealed that the semi-IPN films exhibited good miscibility when CMCH content was lower than 35 and 65 wt% for the films prepared on the glass and Teflon, respectively, resulting in higher light transmittance, thermal stability and tensile strength than the WPU film. Interestingly, the films prepared with the Teflon as the substrate possessed better miscibility and higher storage modulus, thermal stability, tensile strength and solvent-resistance than that with the glass as the substrate over the entire composition range studied here. This difference can be attributed that a strong intermolecular interaction occurred between WPU and CMCH to form a dense architecture, owing to that two kinds of macromolecules all were repulsed from the Teflon surface and forced to concentrate into inner surface. It has been confirmed that the hydrophility and hydrophobility of the solid substrate significantly influenced the structures and properties of the casting films, and using Teflon solid substrate can more effectively improve the miscibility and properties of the semi-IPN materials with hydrophilic character than glass one. We proposed a model describing the formation of WPU/CMCH semi-IPN films cast on the hydrophilic and hydrophobic substrates to illustrate the different structures of two types of films.

Leakage characterization of top select transistor for program disturbance optimization in 3D NAND flash

Highlights•A characterization approach is proposed to quantify TSG leakage under program inhibit.•Optimization of program disturbance has been carried out with this approach.•An optimal TSG Vth pattern is suggested for low leakage and high boosting efficiency.•Upper TSG plays dominant role in preventing DIBL leakage in optimal TSG vth pattern.•Lower TSG assists to suppress trap assisted BTBT between dummy WL to edge of TSG.

Novel rearrangements of macrocyclic trichothecenes

AbstractMyrotoxin B (1) readily undergoes electrophilic addition of water and BrOH to give myrotoxin B hydrate (5) and the bromohydrin 2, respectively. When these hemiketals are treated with DBU in THF, they undergo novel rearrangements apparently via their open chain hydroxyketone forms. Myrotoxin B hydrate (5) gives a spirocyclic ketal 6 which is only slightly less cytoxic than 5, even though the macrocyclic ring system has undergone substantial alteration.

Rhinitis, sinusitis, and upper airway diseaseNasal IL-4+CXCR5+CD4+ T follicular helper cell counts correlate with local IgE production in eosinophilic nasal polyps

BackgroundLocally produced IgE contributes to the initiation and development of eosinophilic inflammation in eosinophilic nasal polyps independent of systemic atopy. However, whether CXCR5+CD4+ T follicular helper (TFH) cells are involved in local IgE production at mucosal sites remains unexplored.ObjectiveWe sought to explore the presence, phenotype, and function of CXCR5+CD4+ TFH cells in eosinophilic nasal polyp tissues compared with noneosinophilic nasal polyp and control normal nasal tissues.MethodsTFH cell-surface phenotypes and subsets and B-cell subsets in nasal tissues and peripheral blood were studied by means of flow cytometry. Immunohistochemistry was used to detect the tissue location of TFH cells. Sorted nasal TFH cells and CXCR5− T cells were cultured with autologous naive B cells purified from blood.ResultsNasal TFH cells expressed inducible costimulator, programmed cell death protein 1, and the transcription factor B-cell lymphoma 6 (Bcl-6) at an intermediate level when compared with bona fide TFH cells in tonsils and circulating TFH cells. Although counts of total TFH cells and IL-21+, IFN-γ+, and IL-17+ TFH cells were increased in both eosinophilic and noneosinophilic nasal polyp tissues compared with those in normal nasal tissues, IL-4+ TFH cell counts were only increased in eosinophilic polyp tissues. IL-4 and IL-21 were involved in polyp TFH cell–induced IgE production from naive B cells, and nasal IL-4+ TFH cell counts correlated highly with local IgE levels in vivo. IL-4+Bcl-6+CD4+ TFH cells were identified in ectopic lymphoid structures in eosinophilic nasal polyps. TFH cells also positively correlated with germinal center B cells and plasma cells in nasal tissues.ConclusionNasal IL-4+ TFH cells might be involved in local IgE production in eosinophilic nasal polyps.

ArticleEssential Roles of S-Nitrosothiols in Vascular Homeostasis and Endotoxic Shock

AbstractThe current perspective of NO biology is formulated predominantly from studies of NO synthesis. The role of S-nitrosothiol (SNO) formation and turnover in governing NO-related bioactivity remains uncertain. We generated mice with a targeted gene deletion of S-nitrosoglutathione reductase (GSNOR), and show that they exhibit substantial increases in whole-cell S-nitrosylation, tissue damage, and mortality following endotoxic or bacterial challenge. Further, GSNOR−/− mice have increased basal levels of SNOs in red blood cells and are hypotensive under anesthesia. Thus, SNOs regulate innate immune and vascular function, and are cleared actively to ameliorate nitrosative stress. Nitrosylation of cysteine thiols is a critical mechanism of NO function in both health and disease.

Special Section on CAD/Graphics 2013SCAPE-based human performance reconstruction

Highlights•We proposed a framework to reconstruct human performance from low quality Kinect data with SCAPE model.•We devised a method to enlarge the SCAPE pose training database.•We introduced a hierarchical method with articulated ICP to robustly track the performer's motion.

Special Issue on CAD/Graphics 2017Joint analysis of shapes and images via deep domain adaptation

Highlights•We implement a CNN architecture to jointly analyze shapes and images.•The core of our architecture is a deep domain adaptation algorithm.•Our approach has superior performance for the few-shot learning problem.•Our approach facilitates the recognition and retrieval tasks across modalities.

ArticlesEfficacy, safety, and immunogenicity of an oral recombinant Helicobacter pylori vaccine in children in China: a randomised, double-blind, placebo-controlled, phase 3 trial

SummaryBackgroundHelicobacter pylori is one of the most common gastric pathogens, affecting at least half the world's population, and is strongly associated with gastritis, peptic ulcer, gastric adenocarcinoma, and lymphoma. We aimed to assess the efficacy, safety, and immunogenicity of a three-dose oral recombinant H pylori vaccine in children in China.MethodsWe did this randomised, double-blind, placebo-controlled, phase 3 trial at one centre in Ganyu County, Jiangsu Province, China. Healthy children aged 6–15 years without past or present H pylori infection were randomly assigned (1:1), via computer-generated randomisation codes in blocks of ten, to receive the H pylori vaccine or placebo. Participants, their guardians, and study investigators were masked to treatment allocation. The primary efficacy endpoint was the occurrence of H pylori infection within 1 year after vaccination. We did analysis in the per-protocol population. This trial is registered with ClinicalTrials.gov, number NCT02302170.FindingsBetween Dec 2, 2004, and March 19, 2005, we randomly assigned 4464 participants to either the vaccine group (n=2232) or the placebo group (n=2232), of whom 4403 (99%) participants completed the three-dose vaccination schedule and were included in the per-protocol efficacy analysis. We extended follow-up to 3 years. We recorded 64 events of H pylori infection within the first year (14 events in 2074·3 person-years at risk in the vaccine group vs 50 events in 2089·6 person-years at risk in the placebo group), resulting in a vaccine efficacy of 71·8% (95% CI 48·2–85·6). 157 (7%) participants in the vaccine group and 161 (7%) participants in the placebo group reported at least one adverse reaction. Serious adverse events were reported in five (<1%) participants in the vaccine group and seven (<1%) participants in the placebo group, but none was considered to be vaccination related.InterpretationThe oral recombinant H pylori vaccine was effective, safe, and immunogenic in H pylori-naive children. This vaccine could substantially reduce the incidence of H pylori infection; however, follow up over a longer period is needed to confirm the protection of the vaccine against H pylori-associated diseases.FundingChongqing Kangwei Biological Technology.

The cosmic ray muon tomography facility based on large scale MRPC detectors

AbstractCosmic ray muon tomography is a novel technology to detect high-Z material. A prototype of TUMUTY with 73.6 cm×73.6 cm large scale position sensitive MRPC detectors has been developed and is introduced in this paper. Three test kits have been tested and image is reconstructed using MAP algorithm. The reconstruction results show that the prototype is working well and the objects with complex structure and small size (20 mm) can be imaged on it, while the high-Z material is distinguishable from the low-Z one. This prototype provides a good platform for our further studies of the physical characteristics and the performances of cosmic ray muon tomography.

Mathematical modelling and study of the encoding readout scheme for position sensitive detectors

AbstractEncoding readout methods based on different schemes have been successfully developed and tested with different types of position-sensitive detectors with strip-readout structures. However, how to construct an encoding scheme in a more general and systematic way is still under study. In this paper, we present a graph model for the encoding scheme. With this model, encoding schemes can be studied in a more systematic way. It is shown that by using an encoding readout method, a maximum of n(n−1)2+1 strips can be processed with n channels if n is odd, while a maximum of n(n−2)2+2 strips can be processed with n channels if n is even. Furthermore, based on the model, the encoding scheme construction problem can be translated into a problem in graph theory, the aim of which is to construct an Eulerian trail such that the length of the shortest subcycle is as long as possible. A more general approach to constructing the encoding scheme is found by solving the associated mathematical problem. In addition, an encoding scheme prototype has been constructed, and verified with MRPC detectors.

Electron track reconstruction and improved modulation for photoelectric X-ray polarimetry

AbstractThe key to photoelectric X-ray polarimetry is the determination of the emission direction of photoelectrons. Because of the low mass of an electron, the ionisation trajectory is not straight and the useful information needed for polarimetry is stored mostly in the initial part of the track where less energy is deposited. We present a new algorithm, based on the shortest path problem in graph theory, to reconstruct the 2D electron track from the measured image that is blurred due to transversal diffusion along drift and multiplication in the gas chamber. Compared with previous methods based on moment analysis, this algorithm allows us to identify the photoelectric interaction point more accurately and precisely for complicated tracks resulting from high energy photons or low pressure chambers. This leads to a better position resolution and a higher degree of modulation toward high energy X-rays. The new algorithm is justified using simulations and measurements with the gas pixel detector (GPD), and it should also work for other polarimetric techniques such as a time projection chamber (TPC). As the improvement is restricted in the high energy band, this new algorithm shows limited improvement for the sensitivity of GPD polarimeters, but it may have a larger potential for low-pressure TPC polarimeters.

Tunable emission and applications of Ln3+ doped NaGd(WO4)2 nanocrystals via a facile solvothermal process

AbstractDouble tungstate crystal has outstanding capabilities of gain media for the application in mode-locked ultrafast lasers. Among them, NaGd(WO4)2:Ln3+ is widely using in laser, pH sensing or lighting devices. However, general synthetic methods require high temperature, long reaction time or adjustment of solution pH, which is seriously hinder their related applications. Here, we synthesized NaGd(WO4)2:Ln3+ nanocrystals through a solvothermal strategy. The synthesis was designed to avoid the solvent effect of water. Our nanoparticles with a rod shape and average size is ∼3.8 × 46.3 nm. Furthermore, Terbium and Europium ions co-doped in a single NaGd(WO4)2 host has been obtained, energy migration from Terbium ions to Europium ions also implemented. A series of emission colours (from green to white) were obtained. At last, a distinguished performance NaGd(WO4)2:0.03Tb,0.03Eu based UV-LED equipment was realized. Their adjustable emissions, convenient preparation method and special morphology reveal that NaGd(WO4)2:Ln3+ is a potential candidate for solid-state lasers and UV-LEDs applications.

Effects of glass-to-rubber transition of thermosetting resin matrix on the friction and wear properties of friction materials

AbstractThe present study is to examine the effects of glass-to-rubber transition of resin matrix on the friction and wear characteristics of friction materials, in relation to different types of thermosetting resins. Dynamic mechanical thermal analysis and friction test results revealed that glass-to-rubber transition of thermosetting resins influenced significantly the friction and wear behavior of the composite materials. There was a significant increasing tendency in friction coefficient and wear rate values for all composites when braking temperatures increased to 200 or 250 °C, accompanying the resin matrix converted from glassy state to rubbery state.

Public key encryption with equality test via hash proof system

AbstractPublic key encryption with equality test (PKEET) allows a tester to know whether ciphertexts are the encryptions of a same message or not by using the trapdoors issued from their owners, which is a useful cryptographic primitive can be deployed in many applications, such as in the mechanism of searching over encrypted data. Based on Hash Proof System (HPS) introduced by Cramer and Shoup, this paper presents an oversimplified paradigm for constructing PKEET in the standard model. Compared with the previous works that use identity-based encryption, strongly unforgeable one-time signature or other strong cryptographic primitives, our paradigm requires only the universal2 property of HPS and provides an efficient way to obtain concrete PKEET schemes based on different assumptions in the standard model, since HPS has been shown can be easily realized from a board range of NP languages (e.g., DLIN-based, DCR-based, Lattice-based and so on). Moreover, to demonstrate the practicality of the proposed paradigm, we instantiate it based on two kinds of NP languages respectively, one is based on the decisional Diffie-Hellman (DDH) assumption, the other one is based on the decisional composite residuosity (DCR) assumption, which results in the first concrete PKEET schemes that in the standard model without using pairing operations, and the schemes' security are also based on the standard DDH assumption and the standard DCR assumption respectively.

Integrated absorption-mineralisation for low-energy CO2 capture and sequestration

Highlights•The application of fly ash in chemical regeneration of amine absorbents for CO2 capture and sequestration.•Large CO2 cyclic capacity and solvent regeneration efficiency.•Low energy penalty and cost.•Novel process without thermal regeneration, CO2 compression, or geological storage.

Corticotropin-releasing hormone modulates airway vagal preganglionic neurons of Sprague–Dawley rats at multiple synaptic sites via activation of its type 1 receptors: Implications for stress-associated airway vagal excitation

Highlights•Corticotropin-releasing hormone depolarized airway vagal preganglionic neuron (AVPN).•Corticotropin-releasing hormone caused a tonic excitatory current in AVPN.•Corticotropin-releasing hormone enhanced the glutamatergic synaptic inputs of AVPN.•Corticotropin-releasing hormone enhanced the GABAergic synaptic inputs of AVPN.•Type 1 receptor antagonist blocked the effects of corticotropin-releasing hormone.

Electrodeposition mechanism and characterization of Ni–Mo alloy and its electrocatalytic performance for hydrogen evolution

Highlights•The electrodeposition mechanism of Ni–Mo alloy was investigated.•The Ni80.14Mo19.59 alloy coatings exhibited a spherical and cauliflower-like pattern, with nano-crystal structure.•The Ni–Mo alloy had better catalytic activity for hydrogen evolution.

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