Biography:

One of their most recent publications is Total synthesis of mycothiazole, a polyketide heterocycle from marine sponges. Which was published in journal Tetrahedron.

More information about Hideyuki Sugiyama research including statistics on their citations can be found on their Copernicus Academic profile page.

Hideyuki Sugiyama's Articles: (2)

Total synthesis of mycothiazole, a polyketide heterocycle from marine sponges

AbstractMycothiazole isolated from marine sponges has been efficiently synthesized in a convergent manner. The key reactions involve the thiazole synthesis by dehydrogenation of the thiazolidine with chemical manganese dioxide (CMD), the Stille coupling, and the Nagao asymmetric acetate aldol reaction using the chiral 1,3-thiazolidine-2-thione. This synthesis clearly established the absolute configuration of natural mycothiazole to be (R).

Syntheses of four unusual amino acids, constituents of cyclomarin A

AbstractThe stereoselective syntheses of four unusual amino acids, constituents of cyclomarin A, are described. The protected N-methylhydroxyleucine 2 was synthesized using Evans’ asymmetric azide-transfer reaction. The unusual amino acid 3 was prepared via diastereoselective methylation of the l-aspartic acid derived lactone 13. The stereoselective formation of threo-β-methoxyphenylalanine 4 was performed via aldol reaction using Schöllkopf's chiral glycine enolate. The synthesis of N-reverse prenylated tryptophane 5 was achieved by the AQN ligand-promoted Sharpless regioreversed asymmetric aminohydroxylation protocol.

Advertisement
Join Copernicus Academic and get access to over 12 million papers authored by 7+ million academics.
Join for free!

Contact us