Biography:

In the past P. Vandenabeele has collaborated on articles with A. Pereira and J. Van Pevenage. One of their most recent publications is IL-4 acts synergistically on the IL-2 response of an autoreactive T-cell clone; synergism correlates with increased intracellular IL-2, but not with a modified IL-2 receptor expression☆. Which was published in journal Cellular Immunology.

More information about P. Vandenabeele research including statistics on their citations can be found on their Copernicus Academic profile page.

P. Vandenabeele's Articles: (7)

IL-4 acts synergistically on the IL-2 response of an autoreactive T-cell clone; synergism correlates with increased intracellular IL-2, but not with a modified IL-2 receptor expression☆

AbstractTE44, an H-26-restricted, self-reactive T-cell line, did not produce autocrine-acting growth factors, neither after antigenic nor after mitogenic activation; they remained for their proliferation completely dependent on exogenously added IL-2. Administration of IL-4, which poorly promotes growth by itself, resulted in a 5- to 10-fold enhancement of the specific biological activity of IL-2 on antigen-activated TE44-cells. This synergism was exerted nonreciprocally and required the presence of both lymphokines. IL-4 did not affect the number, nor the affinity, nor the rate of internalization of the high-affinity receptors for IL-2. However, increased levels of intracellular IL-2 were observed, suggesting an effect of IL-4 on the turnover of IL-2. This might allow a prolonged activity of IL-2 or IL-2-associated molecules inside the cell. Furthermore, the lack of autocrine growth factor production by antigen-stimulated TE44 is discussed in terms of its relationship to the autoimmune specifity of these T-cells.

Comparative study of mobile Raman instrumentation for art analysis

AbstractIn archaeometry, one of the main concerns is to extract information from an art object, without damaging it. Raman spectroscopy is being applied in this research field with recent developments in mobile instrumentation facilitating more routine analysis. This research paper evaluates the performances of five mobile Raman instruments (Renishaw RA100, Renishaw Portable Raman Analyser RX210, Ocean Optics RSL-1, Delta Nu Inspector Raman, Mobile Art Analyser - MArtA) in three different laboratories. A set of samples were collected, in order to obtain information on the spectral performances of the instruments including: spectral resolution, calibration, laser cut-off, the ability to record spectra of organic and inorganic pigments through varnish layers and on the possibilities to identify biomaterials. Spectra were recorded from predefined regions on a canvas painting to simulate the investigation of artworks and the capabilities to record spectra from hardly accessible areas was evaluated.

Non-invasive methodology for the identification of plastic pieces in museum environment — a novel approach

Highlights•Simple and fast non-invasive method for the study of plastics in museum environment•Combination of in-situ FTIR with NMR analysis of surface exudates•NMR on surface leachates identifies a greater number of plastic additives than Py–GC–MS

On the definition of Raman spectroscopic detection limits for the analysis of biomarkers in solid matrices

AbstractRaman spectroscopy is one of the techniques that is being advocated for adoption in astrobiology for the detection of extinct or extant life on planetary surfaces extraterrestrially. A discussion on the definition of the Raman spectroscopic limits of detection and the operational factors which influence the data observed is needed for the evaluation of the results. This research paper forms a starting point for the discussion of the meaning of detection limits of biomarker molecules – solids dispersed in solid matrices – and the consequences for astrobiological research as this will have implications on the analytical protocols and spectrometer design for remote field-operated spectrometers.

Illustration of compositional variations over time of Chinese porcelain glazes combining micro-X-ray Fluorescence spectrometry, multivariate data analysis and Seger formulas

Highlights•Fully described methodology for the analysis of silicate glazes of Chinese porcelain samples•The combination of a semi-quantitative analysis of silicate glazes, multi-variate data and statistical analysis.•The use of Seger formula to understand better the composition of the glazes.•New insights into the glaze composition and structure of Chinese porcelain glazes of different time periods.

The use of a multi-method approach to identify the pigments in the 12th century manuscript Liber Floridus

AbstractA selection of illuminations of the 12th century manuscript Liber Floridus was analysed with Raman spectroscopy (in situ and laboratory measurements), X-ray fluorescence spectroscopy, UV-fluorescence photography and infrared reflectography (IRR). The aim of this study is to determine the pigments used, in order to search for anachronisms. Using a combination of Raman spectroscopy (molecular information) and X-ray fluorescence spectroscopy (elemental information) following pigments could be identified: ultramarine (Na8–10Al6Si6O24S2–4), azurite (2CuCO3·Cu(OH)2), caput mortuum (Fe2O3), vermilion (HgS), orpiment (As2S3) and lead white (2PbCO3·Pb(OH)2). Moreover, two synthetic red pigments, PR4 and PR176, and a degradation product, gypsum (CaSO4·2H2O), were present in the manuscript. To establish the origin of the modern materials UV-fluorescence photography was used. Infrared reflectography (IRR) was applied to visualise the underdrawing of the investigated folios.

Evaluation of portable Raman spectroscopy and handheld X-ray fluorescence analysis (hXRF) for the direct analysis of glyptics

Highlights•First combined application of Raman and handheld XRF spectroscopy on glyptics•Discussion of benefits of hXRF and portable Raman spectroscopy for in situ research•Application of these methods for the confirmation of the gemological identification

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