Biography:

In the past Anthony Davies has collaborated on articles with Fritz Nagele and Theodoros Mastichiadis. One of their most recent publications is 2500 Outpatient diagnostic hysteroscopies. Which was published in journal Obstetrics & Gynecology.

More information about Anthony Davies research including statistics on their citations can be found on their Copernicus Academic profile page.

Anthony Davies's Articles: (9)

2500 Outpatient diagnostic hysteroscopies

ObjectiveTo evaluate the feasibility and acceptability of outpatient diagnostic hysteroscopy.MethodsThe outcome of 2500 consecutive outpatient hysteroscopies was analyzed. Cervical dilation was performed when necessary and local anesthesia was not administered routinely. Endometrial biopsy and minor hysteroscopic procedures were carried out when indicated. Findings and outcome were compared according to patient characteristics.ResultsThe most common indication for hysteroscopy was abnormal uterine bleeding (87%). Hysteroscopy was performed successfully in 96.4%, and a complete view of the uterine cavity was obtained in 88.9%. Local anesthesia was used in 29.8% and was associated with the need for cervical dilation; both local anesthetic use and cervical dilation were significantly more often required in nulligravid, nulliparous, and postmenopausal women. Intrauterine pathology was diagnosed in 48%, the highest incidence being found in those 50–60 years old (53.7%). The presence of fibroids was the most common abnormality (24.3%) but was seen in only 6.8% of women older than 60 years. Conversely, the incidence of endometrial polyps increased with age, up to 20.5% in women over 60 years. Endometrial biopsy was performed in 68% and produced adequate tissue for histologic examination in 83.7%. Endometrial hyperplasia or carcinoma was detected in 1%. One hundred sixteen women (4.6%) under-went a minor hysteroscopic procedure.ConclusionOutpatient diagnostic hysteroscopy is both feasible and acceptable in the overwhelming majority of cases, with a high detection rate for intrauterine pathology. This procedure may become as routine in the 21st century as D&C has been in the 20th.

ResearchDesign principles and performance for flooding routing mesh topology spread spectrum LANs

AbstractThis paper presents a family of mesh topology LANs that uses spread spectrum techniques as a method for media access control so as to offer (1) the possibility of simultaneous access to the network, and (2) to provide similar performance to all communication channels while reducing the probability of any collision. For routing, flooding algorithms are proposed. The proposed architecture is characterized by survivability, security and relatively low bandwidth requirements. A LAN member of this family is also analysed. It is built on a topology that consists of a set of inter-communicating sub-LANs and interconnected subgraphs. The topology, the communication and the signalling protocols that support this architecture are presented. Parameters influencing the traffic load of such a LAN are examined, and estimates of the bit error rate (BER) as a function of the parameters are presented.

Rhodopsin, Gq and phospholipase C activation in cephalopod photoreceptors

AbstractWe present characterization of the rhodopsin, Gq and phosphatidylinositol-specific phospholipase C (PLC) from the signal transduction pathway of cephalopod photoreceptors. Cephalopod rhodopsins are unique in possessing a C-terminal extension of proline-rich repeats, and they have a strong tendency to form ordered arrays. Two-dimensional arrays of a full-length and C-terminally-truncated cephalopod rhodopsin have been obtained. The C termini appear to cluster the rhodopsins into small groups. An AlF4−-activated Gq α subunit has been isolated and shown to activate a partially purified PLC β. This 130 kDa PLC, isolated by absorption on heparin agarose, showed a specific activity of 195 nmol of phosphatidylinositol 4,5-biphosphate hydrolysed per milligram of protein per minute in the presence of 1.6 μM free calcium.

How to increase the proportion of hysterectomies performed vaginally☆☆☆★

AbstractObjectives: The main purpose of our study was to identify the patient characteristics of women undergoing hysterectomy and to estimate the proportion of hysterectomies that could be done vaginally by recognized surgical techniques. Study Design: The records of 500 women who underwent hysterectomy were reviewed. The characteristics of patients without an absolute contraindication to vaginal hysterectomy were analyzed. Results: Overall, 96 (19.2%) of our study group underwent vaginal hysterectomy. A total of 382 (76.4%) women were judged not to have an absolute contraindication to this route. The most frequent characteristics of this group were lack of uterine prolapse (76.4%), a myomatous uterus (44.5%), and a need for oophorectomy (43.2%). We did not exclude women who did not have significant uterine prolapse or a history of pelvic surgery or pelvic tenderness and we included those requiring oophorectomy or with a uterine size up to that of 14 weeks’ gestation; with these criteria more than two thirds of the entire study population could undergo vaginal surgery. Conclusions: To maximize the proportion of hysterectomies performed vaginally, gynecologists need to be familiar with surgical techniques for dealing with nonprolapsed uteri, uterine leiomyomas, and vaginal oophorectomy. (Am J Obstet Gynecol 1998;179:1008-12.)

Research paperTyrosine kinase inhibitors as modulators of trastuzumab-mediated antibody-dependent cell-mediated cytotoxicity in breast cancer cell lines

Highlights•TKIs modulate HER2 antigen expression and PBMC-mediated ADCC response.•Trastuzumab ADCC response does not directly correlate with HER2 antigen levels.•LDH-release assay duration and PBMC activity influence the measured ADCC response.•Flow cytometry is more sensitive and consistent than LDH for detection of ADCC.

Regular articleThree-dimensional structure of an invertebrate rhodopsin and basis for ordered alignment in the photoreceptor membrane1

AbstractInvertebrate rhodopsins activate a G-protein signalling pathway in microvillar photoreceptors. In contrast to the transducin-cyclic GMP phosphodiesterase pathway found in vertebrate rods and cones, visual transduction in cephalopod (squid, octopus, cuttlefish) invertebrates is signalled via Gq and phospholipase C. Squid rhodopsin contains the conserved residues of the G-protein coupled receptor (GPCR) family, but has only 35 % identity with mammalian rhodopsins. Unlike vertebrate rhodopsins, cephalopod rhodopsin is arranged in an ordered lattice in the photoreceptor membranes. This organization confers sensitivity to the plane of polarized light and also provides the optimal orientation of the linear retinal chromophores in the cylindrical microvillar membranes for light capture. Two-dimensional crystals of squid rhodopsin show a rectilinear arrangement that is likely to be related to the alignment of rhodopsins in vivo.Here, we present a three-dimensional structure of squid rhodopsin determined by cryo-electron microscopy of two-dimensional crystals. Docking the atomic structure of bovine rhodopsin into the squid density map shows that the helix packing and extracellular plug structure are conserved. In addition, there are two novel structural features revealed by our map. The linear lattice contact appears to be made by the transverse C-terminal helix lying on the cytoplasmic surface of the membrane. Also at the cytoplasmic surface, additional density may correspond to a helix 5–6 loop insertion found in most GPCRs relative to vertebrate rhodopsins. The similarity supports the conservation in structure of rhodopsins (and other G-protein-coupled receptors) from phylogenetically distant organisms. The map provides the first indication of the structural basis for rhodopsin alignment in the microvillar membrane.

High content analysis of the biocompatibility of nickel nanowires

AbstractNickel nanowires, 20 μm long and 200 nm in diameter, were fabricated by electrodeposition into alumina templates, and characterised by superconducting quantum interference device (SQUID) magnetometer, X-ray diffraction and scanning electron microscopy. Biocompatibility studies of nickel nanowires with differentiated THP-1 cell line-derived macrophages were carried out. From a multiparametric assay, using high content analysis (HCA), the critical time points and concentrations of nickel nanowires on THP-1 cellular response were identified. The nanowires displayed little or no toxic effects on THP-1 cells over short incubation times (10 h), and at low concentrations (<100 nanowires per cell). Our findings indicate the potential suitability of these wires for biological and clinical applications.

Clinical ResearchPredicting Technical Success after Fistuloplasty: An Analysis of 176 Procedures

BackgroundSignificant stenoses in arteriovenous fistulae (AVFs) or arteriovenous grafts (AVGs) with limitation of flow and dialysis inadequacy should prompt consideration for fistuloplasty. We sought to identify fistulae, lesions, and patient-specific variables, which predict for outcomes after fistuloplasty.MethodsData were extracted retrospectively from a renal access database from 2011 to 2016 of patients undergoing fistuloplasty. Demographics, comorbidities, outcomes of intervention, and flow rates documented on preintervention and postintervention duplex were collected. Secondary analysis of factors associated with postfistuloplasty flow rates of >600 mL/min, previously shown to be predictive of not requiring future intervention, was performed.ResultsOf 204 attempted fistuloplasties, 176 were completed. One hundred forty (79.5%) were native AVFs and 34 (19.3%), AVGs (no data for 2). Median stenosis treated was 75%, with a majority (43.8%) in the proximal outflow vein. Flow rate on duplex after fistuloplasty was significantly better in AVFs (mean improvement 189.2 mL/min) than that in AVGs (mean improvement 51.8 mL/min; P = 0.034). Greatest flow improvement occurred for needling site stenotic lesions compared with other locations (from anastomosis to central vein) but was not significant. Brachio-brachial or brachio-axillary AVGs did significantly (P < 0.05) worse than all other fistulae types. The presence of hypertension was predicted for postfistuloplasty flow rate of >600 mL/min.ConclusionsFlow rates after fistuloplasty vary depending on the type of fistula treated and the presence of hypertension. Knowledge of this can lead to better patient selection and counseling for fistuloplasty.

Regular ArticleProjection Structure of an Invertebrate Rhodopsin

AbstractRhodopsin is the G-protein-coupled membrane receptor that initiates the visual transduction cascade in retinal photoreceptors. In the present study rhodopsin from the dark-adapted retinas of squid (Loligo forbesi) was detergent-extracted, purified, and reconstituted into native squid photoreceptor lipids following proteolytic cleavage of its proline-rich C-terminus. Two-dimensional crystals of C-terminally truncated rhodopsin reconstituted from octyl glucoside solution formed in a p2221lattice (a = 44 Å,b = 131 Å). Electron micrographs of frozen-hydrated crystals were processed and a projection structure to 8 Å resolution was calculated. The projection map obtained is very similar to maps previously determined for bovine and frog rhodopsins although the crystal packing of the molecules is quite different. Comparison of the maps shows that the arrangement of α-helices in the proteins is very similar despite their great phylogenetic distance; this structure is likely to be present in the whole superfamily of G-protein-coupled receptors. Invertebrate rhodopsins have a large insertion in the helix 5–helix 6 loop. Assignment of an additional density in the squid rhodopsin map to this region supports a previously proposed helix assignment and identifies the end-to-end contacts as helices 1 and 5.

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