Biography:

One of their most recent publications is A parallel alternating direction implicit preconditioning method☆. Which was published in journal Journal of Computational and Applied Mathematics.

More information about Hong Jiang research including statistics on their citations can be found on their Copernicus Academic profile page.

Hong Jiang's Articles: (31)

A parallel alternating direction implicit preconditioning method☆

AbstractThe alternating direction implicit (ADI) iterative method is an efficient iterative method to solve systems of linear equations due to its extremely fast convergence. The ADI method has also been used successfully as a preconditioner in some other iterative methods, such as the preconditioned conjugate gradient. In this paper a parallel algorithm for the ADI preconditioning is proposed. In this algorithm, several steps of the ADI iteration are computed simultaneously. This means that several tridiagonal systems that are traditionally solved sequentially are now solved concurrently. The high performance of this algorithm is achieved by increasing the degree of parallelism and reducing memory contention. The algorithm can easily be implemented in a multiprocessor architecture. Experiments have been conducted on the Myrias SPS-2 computer with 64 processors and good performance of this algorithm is observed.

Regular articleBiomarkers, genomics, proteomics, and gene regulationQuantitatively Controlling Expression of miR-17∼92 Determines Colon Tumor Progression in a Mouse Tumor Model

The miRNA cluster miR-17∼92 targets mRNAs involved in distinct pathways that either promote or inhibit tumor progression. However, the cellular and molecular mechanisms underlying miR-17∼92 cluster-mediated protumorigenic or anti-tumorigenic effects have not been studied. Herein, we determined that inhibition of colon cancer progression is dictated by quantitatively controlling expression of the miR-17∼92 cluster. miR-19 in the context of the miR-17∼92 cluster at medium levels promoted tumor metastasis through induction of Wnt/β-catenin–mediated epithelial-mesenchymal transition by targeting to the tumor-suppressor gene, PTEN. However, higher levels of the miR-17∼92 cluster switched from PTEN to oncogenes, including Ctnnb1 (β-catenin) via miR-18a, which resulted in inhibition of tumor growth and metastasis. However, overexpression of Ctnnb1in tumor cells with high-level miR-17∼92 did not lead to an increase in the levels of β-catenin protein, suggesting that other factors regulated by higher levels of miR-17∼92 might also contribute to inhibition of tumor growth and metastasis. Those unidentified factors may negatively regulate the production of β-catenin protein. Collectively, the data presented in this study revealed that higher levels of miR-17∼92 were a critical negative regulator for activation of the Wnt/β-catenin pathway and could have a potential therapeutic application.

Regular ArticleTransfection of L929 Cells with Complement Subcomponent C1q B-Chain Antisense cDNA Inhibits Tumor Necrosis Factor-α Binding to Mediate Cytotoxicity and Nitric Oxide Generation

AbstractThe role of complement subcomponent C1q in the modulation of TNF-α binding to L929 cells to mediate cytotoxicity and nitric oxide (NO) generation was investigated. Transfection of L929 with murine C1q B-chain antisense plasmid cDNA rendered them markedly less susceptible to TNF-mediated cytotoxicity coincident with a decreased capacity for TNF-α binding and expression of cell surface C1q protein. The inhibitory effects of L929 transfection with C1q B-chain antisense were transiently expressed at 24 hr post-transfection with full recovery of cellular functions by 72 hr. Transfected L929 cells were fully reconstituted in their TNF-α binding and in their cytotoxic response following exposure to soluble C1q which was bound to their cell surface. Transfection with C1q B-chain antisense also significantly inhibited NO generation by L929 cells in response to stimulation by TNF-α, IFN-α/β, and LPS. Taken together, these results indicate that endogenously synthesized C1q is prerequisite for binding of TNF-α to L929 cells to mediate cytotoxicity and NO generation.

Proposals for the propagation of quantum time-dependent self-consistent field equations

AbstractThree proposals for the propagation of the quantum time-dependent self-consistent field equations are presented. One is obtained by combining Zhu and Zhao's time-independent-like split-operator method [W.S. Zhu, X.S. Zhao, J. Chem. Phys. 105 (1996) 9536] and a predictor–corrector technique. By defining a time-independent quasi-Hamiltonian operator for the total system, two new split-operator propagators are proposed. Comparisons with the simple split-operator and second-order difference methods in a two-dimensional model system, the Henon–Helies potential, show that the three new methods all have better accuracy and higher stability.

CorrespondenceA prospective clinical study of interventional ultrasound sclerotherapy on women with hydrosalpinx before in vitro fertilization and embryo transfer

In this prospective clinical study, ultrasound-guided transvaginal aspiration and sclerotherapy with 98% ethanol was performed before the IVF cycle in 33 patients with hydrosalpinx. The results showed that ultrasound aspiration and sclerotherapy could improve the endometrial receptivity and outcomes of IVF, with no recurring sign of the hydrosalpinx and no adverse effect on ovarian reserve or responsiveness during the IVF procedure.

PathophysiologyMini-Symposium on the Pathophysiology of Cardiac ArrhythmiasElectrical restitution determined by epicardial contact mapping and surface electrocardiogram: its role in ventricular fibrillation inducibility in swine

AbstractObjectiveThe roles of electrical restitution determined by epicardial contact mapping and surface electrocardiogram (ECG) in the inducibility of ventricular fibrillation (VF) were evaluated.MethodsTen epicardial unipolar electrograms using contact mapping and the surface ECGs were simultaneously recorded in 7 swine. Activation-recovery interval (ARI) and QT-interval restitution curves were constructed. Steady-state pacing protocol was performed to induce VF. Ventricular fibrillation threshold was defined as the longest pacing interval for inducing VF. Statistical correlation analysis was performed to determine the relationship between local ARI restitutions, QT-interval restitution, and ventricular fibrillation threshold.ResultsOne hundred thirteen restitution curves were constructed (50 in left ventricular sites, 52 in right ventricular sites, and 11 in surface ECG lead II) from 11 steady-state pacing procedures. Statistical correlation between the slopes of the QT restitution curve and the slopes of regional ARI restitution curves was noted in several mapping sites. Ventricular fibrillation threshold significantly related to the local ARI restitution curve slope for the right ventricular apex (R = 0.752, P = .019) and the QT-interval restitution curve slope (R = 0.802, P = .005).ConclusionThere is a significant correlation between the local ARI restitutions and the QT-interval restitutions, both of which were associated with VF inducibility.

Original ArticleInduction of Anagen in Telogen Mouse Skin by Topical Application of FK506, a Potent Immunosuppressant

The effect of topical application of FK506 on the normal hair cycle of C57BL/6J mice was investigated. When telogen mice (7 weeks of age) were treated topically with 1 μmol FK506 on days 0 and 3, 50% of the tested mice entered anagen by day 9 and 100% by day 16. With 0.1 μmol of FK506 is dose dependent. In control mice, a spontaneous shift from telogen to anagen started on day 14, and 30% of the control animals were in anagen at day 19. Histologic studies revealed that FK506 markedly stimulated the skin and thickened it. The depth and size of hair follicles were also markedly increased in FK506-treated skin compared to control skin. The data on hair growth also support the contention that FK506 induces early onset of anagen and stimulates hair growth. the hair growth stimulated by FK506 looked normal and the hairs were of normal length. The hair growth was restricted to the site of application. These results clearly demonstrate that topical application of FK506 induces anagen hair growth in telogen mouse skin and indicate that the hair-growth-stimulating effect of FK506 is due at least in part to its promoting effect on the hair cycle.

Spinocerebellar ataxia type 6 in Mainland China: Molecular and clinical features in four families

AbstractThe hereditary spinocerebellar ataxias (SCAs) are a clinically and genetically heterogeneous group of neurodegenerative disorders. The genes causing 11 of these diseases have been identified. To date, there is no report of SCA type 6 (SCA6) in Mainland Chinese. Using a molecular approach, we investigated SCA6 as well as other SCA subtype in 120 Mainland Chinese families with dominantly inherited ataxias and in 60 Mainland Chinese patients with sporadic ataxias. Clinical and molecular features of SCA6 were further characterized in 13 patients from 4 families. We found that SCA3/MJD was the most common type of autosomal dominant SCA in Mainland Chinese, accounting for 83 patients from 59 families (49.2%), followed by SCA2 (8 [6.7%]), SCA1 (7 [5.8%]), SCA6 (4 [3.3%]), SCA7 (1 [0.8%]), SCA8 (0%), SCA10 (0%), SCA12 (1 [0.8%]), SCA14 (0%), SCA17 (0%) and DRPLA (0%). The genes responsible for 40 (33.3%) of dominantly inherited SCA families remain to be determined. Among the 60 patients with sporadic ataxias in the present series, 3 (5.0%) were found to harbor SCA3 mutations, whereas none were found to harbor SCA6 mutations. In the 4 families with SCA6, we found significant anticipation in the absence of genetic instability on transmission. This is the first report of geographic cluster of families with SCA6 subtype in Mainland China.

Surface science letterAdsorption mode change from adlayer- to restructuring-type with increasing coverage, evidenced by structural determination of c(2 × 2)→(4 × 4)→(5 × 5) sequence formed on Ni(001) by Li deposition

AbstractWe determined surface structures in a structural sequence c(2 × 2)→(4 × 4)→(5 × 5) formed on Ni(001) at 370 K with increasing Li coverage by a dynamical low-energy electron diffraction analysis. The (4 × 4) and (5 × 5) are complex surface-structures involving restructuring of substrate surface atoms, and are analogous to the previously determined (3 × 3) and (4 × 4) structures formed for LiCu(001). The c(2 × 2) at low coverages is a Li adlayer, so a change of the adsorption mode from adlayer- to restructuring-type is evidenced in the course of increasing coverage within a monolayer range.

Surface science letterAdlayer structure of c(52 × 2)R45° formed on Ni(001) by Li adsorption: Hollow-site adsorption or hexagonal arrangement?

AbstractWe determined the c(52 × 2)R45° adlayer structure formed on Ni(001) by Li deposition at 230 K using a dynamical low energy electron diffraction (LEED) analysis with symmetrized automated tensor LEED. It is an antiphase c(2 × 2) domain structure, in which all Li atoms occupy the hollow sites of the Ni(001) surface at coverage 0.6. This antiphase domain structure is very similar to the previously determined c(52 × 2)R45° formed on Cu(001) by Pb deposition.

Molecular mechanisms in allergy and clinical immunologyIL-4/IL-13 signaling beyond JAK/STAT☆☆☆

AbstractIn the past several years, extensive studies on the mechanisms underlying IL-4 and IL-13 signaling have enabled us to gain insight into how these cytokines regulate immune responses. Because both IL-4 and IL-13 use the IL-4Rα as a receptor component, these cytokines activate many common signaling pathways. Both of these cytokines use Janus kinases (JAKs) to initiate signaling and activate signal transducer and activator of transcription-6 (STAT6), which is a transcription factor required for many of their biologic functions. In addition to JAK/STAT, these cytokines also activate a variety of other signaling molecules that are important in regulating IL-4–induced proliferation and protection from apoptosis. Suppressor of cytokine signaling-1 (SOCS-1) is a molecule that can inhibit the activation of IL-4 signaling through the inhibition of JAKs. The Fes tyrosine kinase is activated by IL-4 and appears to be important in regulating IL-4–induced proliferation through the phosphorylation of insulin receptor substrate (IRS) molecules. IRS molecules are essential for IL-4–induced proliferation through their ability to recruit phosphoinositol-3 kinase to the activated IL-4 receptor kinase. In addition, IL-4 can activate a number of phosphatases including SH2-containing inositol phosphatase (SHIP), SHP-1, and SHP-2. Finally, B-cell lymphoma gene-6 (BCL-6) appears to regulate a subset of IL-4–induced genes. Thus the biologic responses induced by IL-4/IL-13 require a complex interaction of signaling pathways and regulators. (J Allergy Clin Immunol 2000;105:1063-70.)

AbstractsEffect of a short message service intervention on infant feeding practices in Shanghai, China: a prospective, community-based, controlled study

AbstractBackgroundInfant feeding practices can have long-term health effects for children. Short message service (SMS) through mobile telephones has been increasingly used for health promotion and health services. We assessed the effectiveness of an SMS intervention for improvement of infant feeding practices.MethodsWe recruited participants from four community health centres (CHCs) in Shanghai, China. Two CHCs were designated the intervention group and two other CHCs were designated the control group. We recruited participants at the beginning of the third trimester. Mothers were eligible to participate if they: owned a mobile phone, were first-time mothers, were aged older than 20 years, were at less than 13 weeks gestation, had completed at least compulsory junior high school education (up to age 15 years), were carrying a singleton fetus, and had no illness that restricted breastfeeding after childbirth. All participants received routine maternal and child health care. Mothers in the intervention group also received weekly SMS messages for infant feeding from the third trimester to 12 months post-partum. Participants were followed up at 4, 6, and 12 months post-partum. The primary outcome was duration of exclusive breastfeeding (EBF). We compared the duration of EBF between groups by survival analysis.FindingsWe enrolled 582 participants (281 in the intervention group and 301 in the control group). At 6 months after birth, 265 mothers in the intervention and 284 in the control groups were followed up. Participants in the intervention group had a significantly longer median duration of EBF at 6 months compared with those in the control group (11·4 weeks, 95% CI 10·3–12·6 vs 8·9 weeks, 95% CI 7·8–9·9; p<0·0002).InterpretationAn SMS intervention might help to promote EBF for new mothers. Large randomised controlled trials are needed to further explore this approach.FundingNestlé Foundation, Shanghai Municipal Health Bureau.

Poster AbstractsTask shifting of traditional birth attendants in rural China: a qualitative study of the implementation of institution-based delivery policy

AbstractBackgroundInstitution-based delivery, with the ultimate goal of universal access to skilled birth attendance, has been selected as a key strategy to reduce maternal mortality rate in many developing countries. However, the question of how to engage traditional birth attendants in the advocacy campaign for skilled birth attendance poses several challenges. Here, we use the experience of task shifting of traditional birth attendants in rural Guangxi Zhuang Autonomous Region, China, as a case study to illustrate how traditional birth attendants could be well integrated into the health system in rural regions.MethodsWe used qualitative research methods, including 28 document reviews (17 published manuscripts, six policy documents, one research report, one doctoral dissertation, and three websites) and 32 individual in-depth interviews with regional and local politicians, policy makers, health-care managers, health-care providers, civil society members, village women cadres, traditional birth attendants, village maternal health workers, mothers, and mother-in-laws. The research has been approved by the Ethical Board of School of Public Health, Fudan University, China.FindingsFrom 1998 to 2012, the rate of institutional-based childbirth increased from 45·7% to 99·7%, and maternal mortality rate decreased from 86·0 per 100 000 livebirths to 27·2 per 100 000 livebirths in Guangxi Zhuang Autonomous Region. Traditional birth attendants' role of providing in-home care during childbirth was restructured, and their social role was strengthened as a result of task shifting. Traditional birth attendants were shifted to act as village maternal health workers to promote perinatal care and institution-based delivery. They were designed to function at the bottom level of the rural health network (county–township–village), acting as the link between women and the health system. A key policy document formalised the role of village maternal-health workers and supported the task-shifting process, which involved engaging with all government and non-governmental organisations (eg, women's federation, youth organisations, and academic associations), training traditional birth attendants for their new role, and providing incentives and sanctions for human resources management.InterpretationThe task-shifting experience, implemented in accordance with the key policy document, in Guangxi was an example of successfully engaging traditional birth attendants in the promotion of institution-based delivery.FundingThe study was supported by the China–UK Global Health Support Programme (GHSP-CS-OP1-02) and partly by the European Union Sixth Framework Programme HEPVIC (EU517746).

C/T polymorphism of the intercellular adhesion molecule-1 gene (exon 6, codon 469). A risk factor for coronary heart disease and myocardial infarction

AbstractBackground: The intercellular adhesion molecule-1 (ICAM-1) mediates the interaction of activated endothelial cells with leukocytes and plays a fundamental role in the pathogenesis of coronary atherosclerosis. ICAM-1 single-base C/T polymorphism, which determines an amino acid substitution in the ICAM-1 protein in exon 6 codon 469, has been described. Our purpose was to determine whether this C/T polymorphism influences the risk of coronary heart disease (CHD) and myocardial infarction (MI) in humans. Methods and results: We enrolled 349 patients with angiographically documented CHD, including a sub-group of 179 patients with acute or chronic MI. The control group consisted of 213 patients with normal left ventricular function and no documented evidence of CHD. All patients and controls were Germans genotyped by polymerase chain reaction and allele-specific oligonucleotide techniques for the ICAM-1 polymorphism. In the patients with CHD and MI the frequencies of the T genotype (TT+TC) were significantly higher than the CC genotype compared to the control subjects (P<0.001). With the additional use of multivariable logistic regression analysis for CHD (TT+TC versus CC; P=0.011, odds ratio 2.21, 95% CI 1.20–4.07), we found a significant association between CHD and MI and the TT and TC genotype of the ICAM-1 gene polymorphism. Conclusions: These results suggest that the TT and TC genotype of the ICAM-1 gene polymorphism in codon 469 is a genetic factor that may determine an individual’s susceptibility for CHD and MI.

Original articleBiomedicalEffects of Sympathetic Nerve Stimulation on Ischemia-induced Ventricular Arrhythmias by Modulating Connexin43 in Rats

BackgroundIncreased cardiac sympathetic nerve activity is thought to contribute to ventricular tachyarrhythmias during acute myocardial ischemia (MI). However, the mechanism is not completely understood. This study investigated the effects of sympathetic nerve stimulation (SNS) on ventricular tachyarrhythmias and connexin43 (Cx43) during acute MI in rats.MethodsNinety five male Wistar rats were randomly assigned into four groups receiving the following treatments: myocardial ischemia with sympathetic nerve stimulation (MI-SNS, n = 25), sham-operation treated with sham stimulation (SO, n = 20), myocardial ischemia with sham stimulation (MI, n = 25), myocardial ischemia pretreated with sympathetic nerve stimulation (pSNS-MI, n = 25).ResultsDuring the 30-min ischemia, the incidence of ventricular tachyarrhythmias, i.e., ventricular tachycardia or ventricular fibrillation (VT/VF) was increased in the MI-SNS group and decreased in the pSNS-MI group compared to that in the MI group (p <0.05 for both). The total amount of Cx43 protein was significantly decreased in the MI-SNS group but not in the MI group and the pSNS-MI group. The amount of phosphorylated Cx43 in the MI-SNS group was significantly lower compared to that in the SO group and the MI group (p <0.05). However, the amount of phosphorylated Cx43 was significantly increased in the pSNS-MI group compared to that in the MI group and the MI-SNS group (p <0.05).ConclusionsSNS promoted the degradation of Cx43 protein, especially the phosphorylated Cx43 protein, whereas pSNS inhibited the ischemia-induced loss of phosphorylated Cx43 during acute MI. These changes may be related to the pro- or anti-arrhythmic effect of SNS or pSNS during acute MI.

Tumor-derived recognition factor (TDRF) induces production of TNF-α by murine macrophages, but requires synergy with IFN-γ alone or in combination with IL-2 to induce nitric oxide synthase

AbstractA constitutively produced soluble activity, designated tumor-derived recognition factor (TDRF), from L1210, P815 and EL4 tumor targets, was previously shown to synergize with interferon-γ (IFN-γ) and subactivating concentrations of interleukin-2 (IL-2) to induce murine macrophage production of tumor necrosis factor-α (TNF-α) and nitric oxide (NO) for cytotoxicity of the target of origin. Another study had suggested that TDRF upregulated both TNF-α receptor (TNF-αR) and IFN-γ receptor (IFN-αR) mRNA synthesis, as well as increased TNF-α and IFN-γ binding to their receptors. In the present study, we have further characterized the concentration-dependent macrophage activating potential of TDRF alone and in synergy with IFN-γ or IFN-γ and subactivating concentrations of IL-2. Higher concentrations of TDRF acted independently on inflammatory C3H/FeJ mouse macrophage to induce expression of TNF-α mRNA and release of TNF-α, but failed to induce nitric oxide synthase (NOS) mRNA expression and NO generation. At lower concentrations, TDRF synergized with either IFN-γ alone or in combination with IL-2 to stimulate a dose-related increase in the expression of TNF-α mRNA and secretion of TNF-α, as well as increased induction of NOS mRNA and cytotoxic NO generation by macrophage. MCA tumor targets which did not produce TDRF activity were killed by macrophage that had been activated by exogenously added L1210-derived TDRF in synergy with IFN-γ or in combination with subactivating concentrations of IL-2, but not by TDRF alone. Taken together, our results indicate that TDRF acted independently in a dose-dependent fashion to induce macrophage synthesis and release of TNF-α, but in the absence of IFN-γ or in combination with IL-2 failed to induce the NOS enzyme which was necessary for cytotoxic NO generation. Thus TDRF appears to be a sufficient second signal for IFN-γ-primed macrophage or alternatively a sufficient third signal for IFN-γ and IL-2 treated macrophage to culminate the activation process for NOS mRNA synthesis and NO-mediated tumor cytotoxicity.

Pressure dependent mechanical properties of calcium carbides

AbstractThe mechanical properties of newly synthesized Ca2C3 and Ca2C under pressure have been studied by using the first-principles calculations with generalized gradient approximation. The equilibrium geometry, elastic stiffness constants, various moduli, and Pugh's ratio of the C2/m phase of Ca2C3 and the C2/m and Pnma phases of CaC2 are systematically studied. The elastic stiffness constants of C2/m-Ca2C3 under 0–30GPa, C2/m-Ca2C under 0–7.5 GPa, and Pnma-Ca2C under 7.5–30 GPa satisfy the Born−Huang mechanical criteria. The three phases of calcium carbides exhibit ductile characteristics. The surface constructions of bulk and Young's moduli illustrate the mechanical anisotropy of Ca2C3 and Ca2C. Our results are consistent with previously obtained experimental and theoretical data and have significant implications for the application of calcium carbides.

Modelling the net primary productivity of temperate forest ecosystems in China with a GAP model

AbstractThe dynamics of net primary productivity (NPP) and biomass of temperate forests Northeastern China was examined by comparing field data with simulation results from the ZELIG model. For broad-leaf/Korean pine mixed forests, biomass was estimated between 198 and 370 Mg ha−1 (dry weight), and NPP was estimated at 8–20 Mg ha−1 per year (dry weight). The simulation results indicate that NPP in mixed forests would discontinuously increase over the next 200–400 years, to a maximum value of 21 Mg ha−1 per year. Simulation of biomass dynamics suggests that it would peak in about 300 years at approximately 400 Mg ha−1, and then slowly decline. For oak forests, simulated NPP ranges from 5 to 13 Mg ha−1 per year, with biomass estimated at 120–310 Mg ha−1. In aspen–birch forests, maximum NPP and biomass values were 18 Mg ha−1 per year and 320 Mg ha−1, respectively, while minimum NPP and biomass values were 7 Mg ha−1 per year and 50 Mg ha−1, respectively. Larch forests were found to have lower values of NPP and biomass than other forest types, with NPP between 5 and 12 Mg ha−1 per year, and biomass between 50 and 275 Mg ha−1. Comparison of measured field data with ZELIG simulated values indicates only a 8–13% error, based on more than 50 independent plots, with a mean accuracy for simulated NPP between 88 and 93%.

Original articleCirculating long non-coding RNA PCGEM1 as a novel biomarker for gastric cancer diagnosis

AbstractAimPrevious studies have confirmed that overexpression of the long non-coding RNA prostate cancer gene expression marker 1 (PCGEM1) contributes to the invasion and metastasis of gastric cancer (GC) cells. However, the expression of circulating PCGEM1 in the plasma of GC patients and its clinical value remain unclear.MethodsA total of 317 patients with GC and 100 healthy subjects were enrolled in this study. Circulating PCGEM1 was detected by reverse transcription-polymerase chain reaction. The diagnostic value of plasma PCGEM1 was evaluated by receiver operating characteristic curves and the area under the curve (AUC) value.ResultsThe expression level of PCGEM1 in the GC group was significantly higher than that in the healthy control subjects. In addition, the PCGEM1 expression level was associated with tumor differentiation and TNM stage. The AUC value of PCGEM1 was higher than that of other conventional tumor markers (CEA, CA12-5, CA72-4, AFP, and CA19-9), although the combination of all markers showed the highest predictive value.ConclusionPlasma PCGEM1 may be a potential novel circulating biomarker for GC diagnosis and prognosis.

The spatial and seasonal variation characteristics of fine roots in different plant configuration modes in new reclamation saline soil of humid climate in China

Highlights•More than 60% of FRB were concentrated in the soil depth range between 0 and 20 cm.•The salinity should be below 1.5 mS/cm, which was conducive the growth of plant roots.•Tree-shrub stand model may be the best configuration mode for ecological restoration in saline soil.

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