In the past Yang Yu has collaborated on articles with Shouguo Zhang and Shuang Shaomin. One of their most recent publications is Age and cooling history of the kiglapait Intrusion from an 40Ar39Ar study. Which was published in journal Geochimica et Cosmochimica Acta.

More information about Yang Yu research including statistics on their citations can be found on their Copernicus Academic profile page.

Yang Yu's Articles: (216)

Age and cooling history of the kiglapait Intrusion from an 40Ar39Ar study

Abstract40Ar39Ar age spectra of hornblende, biotite, and feldspars from the Kiglapait layered intrusion, Labrador, give closure ages that define the subsolidus cooling history of the intrusion and its surroundings. Biotites give very good plateaus, but U-shaped age spectra are typical for hornblende, antiperthite, and plagioclase, and a spectrum of multi-plateau segments is found in mesoperthites. Isochron studies reveal an age range from 1298 ± 14 Ma for hornblende to 1217 ± 28 Ma for plagioclase. Multiple linear arrays or clusters appear on the isochron diagrams of perthitic feldspars, indicating the effect of excess argon. For antiperthite, this excess argon resides mainly in the plagioclase domains, based on its inverse correlation with K/Ca.With the highest closure temperature, the hornblende age is very close to the published Sm/Nd rockmineral isochron age of 1305 ± 22 Ma and gives a good approximation to the crystallization age. Calculated closure temperatures of different feldspars, combined with published values for hornblende and biotite, show that this intrusion cooled rapidly down to an ambient temperature of about 240°C in the first 20 Ma after its crystallization, then underwent extremely slow cooling for a long time. Combining these results with the published pre-intrusion ambient temperature of about 350°C, a regional slow cooling is revealed, and this implies a late uplift of the region during and after the Kiglapait magmatism.

The rhomb unit structural model of amorphous alloys

AbstractAccording to both the basic facts of the peak distribution principles in RDF(r) curves and the size of the short-range order (SRO) in amorphous alloys obtained from experiments, the molecular unit that constitutes the metallic glass structure is to be the rhomb unit by calculation within 8 f.c.c. crystalline cells. On the basis of this work, the authors proposed the rhomb unit structural model (RUSM) of amorphous alloys, and assume the structure of amorphous alloys as the random packing of rhomb units. In this paper the peak positions of G(r) and the relative magnitude of these peaks of NiP amorphous alloys are calculated by means of RUSM. The calculated results are consistent with experimental ones.

ChemistrySynthesis and structure characteristics of the new ternary boride (V1−xNbx)2B3

AbstractThe new ternary compound (V1−xNbx)2B3 was synthesized by both single crystal and polycrystalline methods. It belongs to the V2B3-type structure, which crystallizes in the orthorhombic space group Cmcm (No. 63), with Z = 4. The unit cell parameters of the ternary compound vary in the ranges 3.1086–3.162 Å, 18.5817–19.107 Å and 3.0114–3.086 Å for a, b and c respectively, with the V/Nb ratios in the starting materials varied from 3 to 12. The crystal structure of one representative single crystal of (V1−xNbx)2B3 was studied by single crystal X-ray diffractometry. The structure refinement converged at an R(F2) value or 0.042 for 1165 reflections. For the single crystal studied, the composition calculated from the refinement was (V0.82Nb0.18)2B3. In the crystal structure of (V0.82Nb0.18)2B3, 73.9% of the niobium atoms occupy the V(1) position, while the remaining atoms occupy the V(2) position. The influence of the V/Nb ratio in the starting materials on the formation of the (V1−xNbx)2B3 compound and the unit cell parameters is discussed.

Study on molecular recognition of para-aminobenzoic acid species by α-, β- and hydroxypropyl-β-cyclodextrin

AbstractThe molecular recognition interaction of α-cyclodextrin, β-cyclodextrin and hydroxypropyl-β-cyclodextrin by para-aminobenzoic acid (PABA) species was studied by using steady-state fluorescence measurements. PABA can exist as one of three species (an anionic, neutral on cationic species) due to its amphoteric property. The various factors affecting the inclusion process were examined in detail. The type of species depended on the pH value in the medium. The results suggested that cyclodextrins (CDs) were most suitable for inclusion of the uncharged species of PABA and could cause enhanced fluorescence emission of PABA. A mechanism is proposed to explain the inclusion process.

Original articleAssociation between DNA methylation of SORL1 5′-flanking region and mild cognitive impairment in type 2 diabetes mellitusAssociation entre méthylation de l’ADN de la région flanquante 5′ de SORL1 et déficience cognitive légère dans le cadre d’un diabète de type 2

AbstractObjectivesIn the present study, we examined whether DNA methylation of the sortilin-related receptor 1 (SORL1) 5′-flanking region is associated with the manifestation and clinical presentation of mild cognitive impairment in type 2 diabetes mellitus (T2DM).MethodsOf 84 diabetic patients with mild cognitive impairment (MCI group), 78 diabetic patients without mild cognitive impairment (NMCI group) and 80 age-matched normal controls (NC group), the DNA methylation of the SORL1 5′-flanking region was completely analyzed. The SORL1 methylation ratios of the above three groups were compared statistically. Next, we investigated the correlation between the DNA methylation status and the clinical presentation of diabetes with or without cognitive impairment (MCI and NMCI groups).ResultsThe methylation ratio (86.9%) of MCI patients was significantly higher than that in the NMCI patients (35.9%, P < 0.05) and in the NC group (11.3%, P < 0.05). Moreover, the diabetic patients with methylation alleles had greater ages, longer diabetes duration, lower MOCA scores and higher plasma amyloid Aβ 1-42 levels than those with unmethylation alleles (P < 0.05).ConclusionThese results suggested that the DNA methylation of the SORL1 5′-flanking region may significantly influence the manifestation of mild cognitive impairment in T2DM, and might be associated with its neurocognitive presentation.

On the approximation ability of evolutionary optimization with application to minimum set cover

AbstractEvolutionary algorithms (EAs) are heuristic algorithms inspired by natural evolution. They are often used to obtain satisficing solutions in practice. In this paper, we investigate a largely underexplored issue: the approximation performance of EAs in terms of how close the solution obtained is to an optimal solution. We study an EA framework named simple EA with isolated population (SEIP) that can be implemented as a single- or multi-objective EA. We analyze the approximation performance of SEIP using the partial ratio, which characterizes the approximation ratio that can be guaranteed. Specifically, we analyze SEIP using a set cover problem that is NP-hard. We find that in a simple configuration, SEIP efficiently achieves an Hn-approximation ratio, the asymptotic lower bound, for the unbounded set cover problem. We also find that SEIP efficiently achieves an (Hk−k−18k9)-approximation ratio, the currently best-achievable result, for the k-set cover problem. Moreover, for an instance class of the k-set cover problem, we disclose how SEIP, using either one-bit or bit-wise mutation, can overcome the difficulty that limits the greedy algorithm.

Maximizing submodular or monotone approximately submodular functions by multi-objective evolutionary algorithms

AbstractEvolutionary algorithms (EAs) are a kind of nature-inspired general-purpose optimization algorithm, and have shown empirically good performance in solving various real-word optimization problems. During the past two decades, promising results on the running time analysis (one essential theoretical aspect) of EAs have been obtained, while most of them focused on isolated combinatorial optimization problems, which do not reflect the general-purpose nature of EAs. To provide a general theoretical explanation of the behavior of EAs, it is desirable to study their performance on general classes of combinatorial optimization problems. To the best of our knowledge, the only result towards this direction is the provably good approximation guarantees of EAs for the problem class of maximizing monotone submodular functions with matroid constraints. The aim of this work is to contribute to this line of research. Considering that many combinatorial optimization problems involve non-monotone or non-submodular objective functions, we study the general problem classes, maximizing submodular functions with/without a size constraint and maximizing monotone approximately submodular functions with a size constraint. We prove that a simple multi-objective EA called GSEMO-C can generally achieve good approximation guarantees in polynomial expected running time.

Silencing stromal interaction molecule 1 by RNA interference inhibits the proliferation and migration of endothelial progenitor cells

AbstractKnockdown of stromal interaction molecule 1 (STIM1) significantly suppresses neointima hyperplasia after vascular injury. Endothelial progenitor cells (EPCs) are the major source of cells that respond to endothelium repair and contribute to re-endothelialization by reducing neointima formation after vascular injury. We hypothesized that the effect of STIM1 on neointima hyperplasia inhibition is mediated through its effect on the biological properties of EPCs. In this study, we investigated the effects of STIM1 on the proliferation and migration of EPCs and examined the effect of STIM1 knockdown using cultured rat bone marrow-derived EPCs. STIM1 was expressed in EPCs, and knockdown of STIM1 by adenoviral delivery of small interfering RNA (siRNA) significantly suppressed the proliferation and migration of EPCs. Furthermore, STIM1 knockdown decreased store-operated channel entry 48 h after transfection. Replenishment with recombinant human STIM1 reversed the effects of STIM1 knockdown. Our data suggest that the store-operated transient receptor potential canonical 1 channel is involved in regulating the biological properties of EPCs through STIM1. STIM1 is a potent regulator of cell proliferation and migration in rat EPCs and may play an important role in the biological properties of EPCs.

A hyaluronan-based polysaccharide peptide generated by a genetically modified Streptococcus zooepidemicus

Highlights•Streptococcus zooepidemicus inherently secretes the polysaccharide hyaluronan.•A mutant strain of S. zooepidemicus produces a polysaccharide peptide (PSP).•This artificial PSP is verified to be a hyaluronan-based derivative.•Production of PSP via this genetic modification is novel and illuminating.

N-doped carbon shell coated CoP nanocrystals encapsulated in porous N-doped carbon substrate as efficient electrocatalyst of water splitting

AbstractWater electrolysis is of great importance for high-efficient hydrogen production. Replacing noble metal-based electrocatalysts by highly efficient and inexpensive non-noble metal based catalysts is critical for the practical application of these technologies. Here we report a novel hybrid of nitrogen-doped carbon shell coated CoP nanocrystals encapsulated in porous nitrogen-doped carbon substrate (CoP/PNC), which is synthesized through sol-gel and consequent pyrolysis-oxidation-phosphorization method. The obtained CoP/PNC exhibits promising electrocatalytic performance toward HER and OER due to the synergistic effect between N-doped carbon and CoP nanocrystals. When the CoP/PNC catalyst is applied in a two-electrode water splitting device, the cell potential at 10 mA cm−2 could be as low as 1.68 V. Besides, it still remains current retention of 78.7% after continuous run for 24 h.

Regulation of recombinant Trichinella spiralis 53-kDa protein (rTsP53) on alternatively activated macrophages via STAT6 but not IL-4Rα in vitro

Highlights•RTsP53 has regulatory effects on murine peritoneal macrophages in vitro.•RTsP53 can inhibit inflammatory factors on macrophages by inducing macrophages to alternative activation.•The effect of rTsP53 on macrophages is dependent on STAT6 not IL-4Rα.

Lattice Boltzmann simulations of liquid flows in microchannel with an improved slip boundary condition

Highlights•The defects of the existing schemes are presented.•The external force is included to improve the slip boundary condition.•The unphysical numerical slip is avoided.•The mass conservation at the wall is ensured.•Some slip flows in micro-channel are simulated and analyzed.

Toward brain-actuated car applications: Self-paced control with a motor imagery-based brain-computer interface

Highlights•This study presented the design and online experiments of BCI paradigm for controlling a car.•This paradigm used two distinct motor imagery tasks to generate a multi-task car control strategy.•Five healthy subjects participated in the experiment, and all successfully controlled the car.•The proposed car controlling paradigm potentially provides a complementary way to drive a car.•The proposed BCI car application is still a demonstration and is not ready for the road.

CMAS resistance characteristics of LaPO4/YSZ thermal barrier coatings at 1250°C–1350°C

Highlights•LaPO4/YSZ TBCs were prepared by air plasma spray.•CMAS resistance characteristics of the TBCs at 1250 °C, 1300 °C and 1350 °C for 2 h and 10 h were investigated.•The corrosion products mainly consisted of apatite, anorthite and spinel independent on test temperatures.•The coatings had a high resistance to CMAS infiltration at 1250 °C due to the formation of a sealing layer.•Higher temperatures largely decreased the CMAS viscosity, promoting its penetration.

Effects of laser glazing on CMAS corrosion behavior of Y2O3 stabilized ZrO2 thermal barrier coatings

Highlights•The goal of this study is to tailor YSZ TBC microstructures by laser for alleviating CMAS attack.•The glazed layer on the coating surface is smooth, with a columnar microstructure and some open channels.•In the presence of molten CMAS, the glazed layer remains phase stability and has little evidence of dissolution.•Exposed to thermal shock tests with CMAS deposits, the glazed layer keeps structural integrity.•The open channels act as the CMAS penetration paths, which bring destructive damages to the coating.

Tailoring the carbon shell thickness of [email protected] carbon nanocages for optimized lithium storage

Highlights•Multiple SnCo nanoparticles embed in N-doped carbon nanocages.•[email protected] carbon nanocages with controllable carbon shell thickness.•Enhanced initial discharge capacity, cyclic stability and rate capability as anode.•Enhanced properties are associated with the optimized carbon shell thickness.

Cardiovascular pharmacologyBerberine treatment prevents cardiac dysfunction and remodeling through activation of 5′-adenosine monophosphate-activated protein kinase in type 2 diabetic rats and in palmitate-induced hypertrophic H9c2 cells

AbstractDiabetic cardiomyopathy is the major cause of death in type 2 diabetic patients. Berberine is an isoquinoline alkaloid extract from traditional chinese herbs and its hypoglycemic and hypolipidemic effects make it a promising drug for treatment of type 2 diabetes. We examined if berberine improved cardiac function and attenuated cardiac hypertrophy and fibrosis in high fat diet and streptozotocin induced-type 2 diabetic rats in vivo and reduced expression of hypertrophy markers in palmitate-induced hypertrophic H9c2 cells in vitro. Treatment of diabetic animals with berberine partially improved cardiac function and restored fasting blood insulin, fasting blood glucose, total cholesterol, and triglyceride levels to that of control. In addition, berberine treatment of diabetic animals increased cardiac 5′-adenosine monophosphate-activated protein kinase (AMPK) and protein kinase B (AKT) activation and reduced glycogen synthase kinase 3 beta (GSK3β) activation compared to control. Palmitate incubation of H9c2 cells resulted in cellular hypertrophy and decreased expression of alpha-myosin heavy chain (α-MHC) and increased expression of beta-myosin heavy chain (β-MHC) compared to controls. Berberine treatment of palmitate-incubated H9c2 cells reduced hypertrophy, increased α-MHC expression and decreased β-MHC expression. In addition, berberine treatment of palmitate-incubated H9c2 cells increased AMPK and AKT activation and reduced GSK3β activation. The presence of the AMPK inhibitor Compound C attenuated the effects of berberine. The results strongly indicate that berberine treatment may be protective against the development of diabetic cardiomyopathy.

Endocrine pharmacologyHNF-4α regulated miR-122 contributes to development of gluconeogenesis and lipid metabolism disorders in Type 2 diabetic mice and in palmitate-treated HepG2 cells

AbstractHepatocyte Nuclear Factor-4α (HNF-4α) is a key nuclear receptor protein required for liver development. miR-122 is a predominant microRNA expressed in liver and is involved in the regulation of cholesterol and fatty acid metabolism. HNF-4α is know to regulate expression of miR-122 in liver. We examined how HNF-4α regulated gluconeogenesis and lipid metabolism through miR-122 in vivo and in vitro. Expression of miR-122, HNF-4α, phosphoenolpyruvate carboxykinase (PEPCK), glucose-6-phosphatase (G6Pase), sterol response elementary binding protein-1 (SREBP-1), fatty acid synthase-1 (FAS-1), carnitine palmitoyltransferase-1 (CPT-1) and acetyl Coenzyme A carboxylase alpha (ACCα) were determined in livers of Type 2 diabetic mice and in insulin resistant palmitate-treated HepG2 cells. CPT-1 and phosphorylated ACCα expression were significantly decreased in livers of Type 2 diabetic mice and in palmitate-treated HepG2 cells compared to controls. In contrast, expression of miR-122, HNF-4α, PEPCK, G6Pase, SREBP-1, FAS-1 and ACCα were significantly elevated in liver of Type 2 diabetic mice and in palmitate-treated HepG2 cells compared to controls. Expression of HNF-4α increased whereas siRNA knockdown of HNF-4α decreased miR-122 levels in HepG2 cells compared to controls. In addition, expression of HNF-4α in HepG2 cells increased PEPCK, G6Pase, SREBP-1, FAS-1, ACCα mRNA and protein expression and decreased CPT-1 and p-ACCα mRNA and protein expression compared to controls. Addition of miR-122 inhibitors attenuated the HNF-4α mediated effect on expression of these gluconeogenic and lipid metabolism proteins. The results indicate that HNF-4α regulated miR-122 contributes to development of the gluconeogenic and lipid metabolism alterations observed in Type 2 diabetic mice and in palmitate-treated HepG2 cells.

Adipogenic miR-27a in adipose tissue upregulates macrophage activation via inhibiting PPARγ of insulin resistance induced by high-fat diet-associated obesity

Highlights•MiR-27a in adipose tissue regulated obesity-induced insulin resistance as an inflammatory modulator for the first time.•MiR-27a stimulated macrophage infiltration and polarization via inhibiting PPARγ directly to regulate insulin resistance.•Novel cell co-culture methods of adipocytes and macrophages for mimicking local hypertrophic condition in vivo were used.

Hydrogen-rich saline protects retina against glutamate-induced excitotoxic injury in guinea pig

AbstractMolecular hydrogen (H2) is an efficient antioxidant that can selectively reduce hydroxyl radicals and inhibit oxidative stress-induced injuries. We investigated the protective effects and mechanism of hydrogen-rich saline in a glutamate-induced retinal injury model. Retinal excitotoxicity was induced in healthy guinea pigs by injecting glutamate into the vitreous cavity. After 30 min, hydrogen-rich saline was injected into the vitreous cavity, the peritoneal cavity or both. Seven days later, the retinal stress response was evaluated by examining the stress biomarkers, inducible nitric-oxide synthase (iNOS) and glucose-regulated protein 78 (GRP78). The impaired glutamate uptake was assessed by the expression of the excitatory amino acid transporter 1(EAAT-1). The retinal histopathological changes were investigated, focusing on the thicknesses of the entire retina and its inner layer, the number of cells in the retinal ganglion cell layer (GCL) and the ultrastructure of the retinal ganglion cells (RGCs) and glial cells. Compared with the glutamate-induced injury group, the hydrogen-rich saline treatment reduced the loss of cells in the GCL and thinning of the retina and attenuated cellular morphological damage. These improvements were greatest in animals that received H2 injections into both the vitreous and the peritoneal cavities. The hydrogen-rich saline also inhibited the expression of glial fibrillary acidic protein (GFAP) in Müller cells, CD11b in microglia, and iNOS and GRP78 in glial cells. Moreover, the hydrogen-rich saline increased the expression of EAAT-1. In conclusion, the administration of hydrogen-rich saline through the intravitreal or/and intraperitoneal routes could reduce the retinal excitotoxic injury and promote retinal recovery. This result likely occurs by inhibiting the activation of glial cells, decreasing the production of the iNOS and GRP78 and promoting glutamate clearance.

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