Biography:

In the past Yasushi Saga has collaborated on articles with Mitsuaki Suzuki and Michitaka Ohwada. One of their most recent publications is Sensitization of human uterine cervical cancer cells to radiation using paclitaxel. Which was published in journal Current Therapeutic Research.

More information about Yasushi Saga research including statistics on their citations can be found on their Copernicus Academic profile page.

Yasushi Saga's Articles: (3)

Sensitization of human uterine cervical cancer cells to radiation using paclitaxel

AbstractThe effect of paclitaxel on the in vitro radiation sensitivity of the uterine cervical cancer cell line SKG IIIa was studied in vitro. Three-hour incubation of cells in low-concentration paclitaxel (3 nmol/L), which has little suppressive activity on cell growth, for 3 hours 48 hours before irradiation at 1.5 Gy, produced a cell growth-suppressing effect that was statistically significant compared with that produced by 1.5 Gy irradiation alone. Cell cycle analysis demonstrated a temporary increase in the number of S phase cells after paclitaxel administration, but no G2 or M phase blocking. Although the mechanism by which paclitaxel sensitizes these cells to radiation in vitro is not known, results suggest that paclitaxel may be clinically useful as a radiosensitizer in the treatment of uterine cervical cancer and should be further evaluated.

Original Research ReportIs peritoneal cytology a prognostic factor of endometrial cancer confined to the uterus?

AbstractObjective.The goal of this study was to investigate whether intraoperative peritoneal cytology serves as a prognostic factor in patients with the endometrial cancer limited to the disease confined to the uterus.Methods.From patients with endometrial cancer treated at 2 facilities between 1988 and 2001, 307 patients were selected for retrospective investigation. To be included in this study, patients required (1) full surgical staging including total abdominal hysterectomy/bilateral salpingo-oophorectomy/retroperitoneal lymph node dissection/peritoneal cytology, (2) negative nodes, (3) disease localized to the uterus and (4) endometrioid subtype.Results.The median duration of the follow-up period was 61 months (25th to 75th percentiles: 45 to 92 months). Peritoneal cytology was positive in 32 patients (10.4%). The 5-year survival rate of peritoneal-cytology-positive patients was 87%, significantly lower than that (97%) of cytology-negative patients (P = 0.011). The relationship between the clinicopathological factors including peritoneal cytology and the prognosis was investigated by univariate analysis, and peritoneal cytology positivity, age of 60 years or older, histologic grade (Grades 2 and 3), myometrial invasion of 1/2 or more and vascular invasion were significant prognostic factors (P < 0.05 in all). On multivariate analysis of these factors, peritoneal cytology positivity and histologic grade (Grade 2 and 3) were independent prognostic factors (P < 0.05 each).Conclusions.For the patients with endometrial cancer limited to the disease confined to the uterus in which accurate staging including retroperitoneal lymph node dissection was performed, peritoneal cytology may be an important prognostic factor.

Original articlesDNA Replication Errors are Frequent in Mucinous Cystadenocarcinoma of the Ovary

AbstractTo elucidate the genetic etiology of sporadic epithelial ovarian carcinoma, we examined replication errors (RER) in its two common types, serous cystadenocarcinoma (SAC) and mucinous cystadenocarcinoma (MAC). The subjects were 63 patients with sporadic epithelial ovarian carcinoma, consisting of 34 patients with SAC and 29 with MAC. The specimens were formalin-fixed and paraffin-embedded tissues from the ovary. The presence of RER was examined by polymerase chain reaction using 5 microsatellite markers. Of the 61 informative patients with ovarian carcinoma, RERs were observed at greater than or equal to 1 locus in 15 patients (25%). Four of the 32 SAC patients (13%) were RER-positive, and 11 of the 29 MAC patients (38%) were RER-positive, the incidence being significantly higher in the latter than in the former (P < 0.05). The incidence of RER was not related to the patients' age, stage, histologic grade, or prognosis. The MAC patients in stages I and II showed a relatively high incidence of RER (30%). These results suggest that RER are involved in the development and/or progression of MAC among sporadic epithelial ovarian carcinoma in its relatively early stage.

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