Biography:

In the past Yongqing Wu has collaborated on articles with Yide Ma and James C. Stroud. One of their most recent publications is ArticleFOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT. Which was published in journal Cell.

More information about Yongqing Wu research including statistics on their citations can be found on their Copernicus Academic profile page.

Yongqing Wu's Articles: (4)

ArticleFOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

SummaryAntigen stimulation of immune cells activates the transcription factor NFAT, a key regulator of T cell activation and anergy. NFAT forms cooperative complexes with the AP-1 family of transcription factors and regulates T cell activation-associated genes. Here we show that regulatory T cell (Treg) function is mediated by an analogous cooperative complex of NFAT with the forkhead transcription factor FOXP3, a lineage specification factor for Tregs. The crystal structure of an NFAT:FOXP2:DNA complex reveals an extensive protein-protein interaction interface between NFAT and FOXP2. Structure-guided mutations of FOXP3, predicted to progressively disrupt its interaction with NFAT, interfere in a graded manner with the ability of FOXP3 to repress expression of the cytokine IL2, upregulate expression of the Treg markers CTLA4 and CD25, and confer suppressor function in a murine model of autoimmune diabetes. Thus by switching transcriptional partners, NFAT converts the acute T cell activation program into the suppressor program of Tregs.

Pulse-coupled neural networks and one-class support vector machines for geometry invariant texture retrieval

AbstractThe pulse-coupled neural network (PCNN) has been widely used in image processing. The outputs of PCNN represent unique features of original stimulus and are invariant to translation, rotation, scaling and distortion, which is particularly suitable for feature extraction. In this paper, PCNN and intersecting cortical model (ICM), which is a simplified version of PCNN model, are applied to extract geometrical changes of rotation and scale invariant texture features, then an one-class support vector machine based classification method is employed to train and predict the features. The experimental results show that the pulse features outperform of the classic Gabor features in aspects of both feature extraction time and retrieval accuracy, and the proposed one-class support vector machine based retrieval system is more accurate and robust to geometrical changes than the traditional Euclidean distance based system.

ArticleStructure of the Forkhead Domain of FOXP2 Bound to DNA

SummaryFOXP (FOXP1–4) is a newly defined subfamily of the forkhead box (FOX) transcription factors. A mutation in the FOXP2 forkhead domain cosegregates with a severe speech disorder, whereas several mutations in the FOXP3 forkhead domain are linked to the IPEX syndrome in human and a similar autoimmune phenotype in mice. Here we report a 1.9 Å crystal structure of the forkhead domain of human FOXP2 bound to DNA. This structure allows us to revise the previously proposed DNA recognition mechanism and provide a unifying model of DNA binding for the FOX family of proteins. Our studies also reveal that the FOXP2 forkhead domain can form a domain-swapped dimer, made possible by a strategic substitution of a highly conserved proline in conventional FOX proteins with alanine in the P subfamily. Disease-causing mutations in FOXP2 and FOXP3 map either to the DNA binding surface or the domain-swapping dimer interface, functionally corroborating the crystal structure.

Co-doped SrSnO3 epitaxial thin films on MgO with tunable band gap and room-temperature ferromagnetism

Highlights•Co doped SrSnO3 films were epitaxially grown on MgO single crystal substrates via pulse laser deposition method.•The Co doping level had significant effects on the crystallinity and morphology of the epitaxial films.•The optical band gap of the film was tuned from 4.46 eV to 2.96 eV with different Co doping level.•The room temperature ferromagnetism with the highest Ms of 61 emu/cm3 and Hc of 0.018 T were realized.

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