Biography:

In the past Richard Mann has collaborated on articles with David Agus and Daniel Pieloch. One of their most recent publications is Case reportPrimary lymphoma of the uterine cervix. Which was published in journal Gynecologic Oncology.

More information about Richard Mann research including statistics on their citations can be found on their Copernicus Academic profile page.

Richard Mann's Articles: (5)

Case reportPrimary lymphoma of the uterine cervix

AbstractPrimary lymphoma of the cervix is very rare. A case report is presented and 24 cases published in the English literature are reviewed. Evaluation, staging, treatment, and prognosis of this rare tumor are discussed.

ArticleConstruction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

AbstractA mutant of Moloney murine leukemia virus (M-MuLV), pMOV-ψ−, was constructed by deletion of about 350 nucleotides from an infectious proviral DNA clone between the putative env mRNA 5′ splice site and the AUG that initiates the coding sequence for Pr65gag. Although the parent wild-type proviral clone, pMOV-ψ+, quickly causes a high level of reverse-transcriptase-containing virus particles to be released from transfected NIH/3T3 cells, transfection of pMOV-ψ− into these cells initially results in very little release. By 9 to 10 days after transfection, however, pMOV-ψ−-transfected cells produce infectious virus. Thus pMOV-ψ− has a defect that can be repaired in transfected NIH/3T3 cells, presumably by recombination with a sequence normally present in the cells. Cell lines with pMOV-ψ− stably integrated into chromosomal DNA produce reverse-transcriptase-containing particles that lack detectable M-MuLV RNA but the cells efficiently complement replication-defective, packagable retroviruses. Thus pMOV-ψ− has a defect in the packaging of genomic RNA into virions but can provide in trans the products necessary for virion production. The deletion in pMOV-ψ− appears to define a site required in cis for packaging of MuLV RNA into virions. Cell lines carrying pMOV-ψ− can be used to produce helper-free stocks of natural or synthetic defective retroviruses.

Laboratory InvestigationThe effects of daily cyclophosphamide administration on the development and extent of primary experimental interstitial nephritis in rats

The effects of daily cyclophosphamide administration on the development and extent of primary experimental interstitial nephritis in rats. We examined the effects of daily cyclophosphamide administration on the development and extent of tubulointerstitial nephritis produced in rats injected with tubular basement membranes in adjuvant. 15 mg/kg/day of cyclophophamide completely blocked the development of interstitial lesions, while 2 mg/kg/day enhanced the degree of interstitial injury. When cyclophosphamide in the higher dose was started early in disease, 12 days after immunization, protection from progression was also observed as well as significant reductive improvement. If cyclophosphamide was administered late in disease, 21 days after immunization, no further progression was demonstrable, but substantial injury remained. In the latter two experiments, the beneficial effects of cyclophosphamide could not be explained by a reduction in anti-tubular basement membrane antibodies bound to the kidney. In groups of immunized rats that were tested, however, cyclophosphamide was able to non-specifically impair the delayed-type hypersensitivity response to tubular antigen and PPD. We conclude, therefore, that cyclophosphamide, in high but not low dosage, if given before damage is extensive and prolonged, may successfully inhibit the cellular immune response producing primary interstitial nephritis.

Original ResearchThe Impact of Morbid Obesity on Hospital Length of Stay in Kidney Transplant Recipients

ObjectivesObesity is often associated with higher hospital costs because of longer length of stay (LOS) but this has not been well studied in the kidney transplant population. Therefore, we used national data to compare LOS in select groups of morbidly obese and normal weight recipients after kidney transplant.DesignThis study was a retrospective analysis of the Organ Procurement and Transplant Network/United Network for Organ Sharing database.SubjectsThe study sample consisted of 42,787 morbidly obese (body mass index 35-40 kg/m2) and normal weight (body mass index 18.5-24.9 kg/m2) who underwent primary kidney-only transplantation between 2000 and 2008.Main Outcome MeasuresMorbidly obese and normal-weight subgroups were crudely evaluated for prolonged LOS (>7 days). Logistic regression modeling compared LOS in morbidly obese and normal-weight subgroups with varying characteristics and determined predictors of prolonged LOS.ResultsAll morbidly obese subgroups had significantly higher crude rates of prolonged LOS (P < .05). However, no significant differences in prolonged LOS were seen between any of the morbidly obese or normal-weight subgroups in multivariate analysis. Morbid obesity was an independent predictor of prolonged LOS (P < .001) but not a stronger predictor than that of being African American, having coronary artery disease, diabetes mellitus, or peripheral vascular disease, being 50 to 80 years of age, having a previous transplant or poor functional status. Receiving a deceased-donor transplant and being dialysis dependent >4 years were significantly better predictors of prolonged LOS compared with morbid obesity (P < .05).ConclusionsSome morbidly obese populations have LOS rates that are not significantly different than many commonly transplanted normal weight populations, and the impact morbid obesity has on LOS is not different than many other factors often seen in kidney transplant recipients; therefore, morbid obesity alone should not be a financial consideration in kidney transplant.

Purely vision-based segmentation of web pages for assistive technology

Highlights•We use a novel vision-based method to analyze the layout of a web page.•Our method produces a hierarchical segmentation of the page reflecting its structure.•Vision-based methods are not sensitive to implementation language or complexity.•The visual presentation of a page provides rich information about semantic structure.•This structure can help create modified presentations for users with assistive needs.

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