Biography:

In the past R.J. Benzie has collaborated on articles with T.A. Doran and S.S. Im. One of their most recent publications is Composition of the amniotic fluid and maternal serum in pregnancy☆. Which was published in journal American Journal of Obstetrics and Gynecology.

More information about R.J. Benzie research including statistics on their citations can be found on their Copernicus Academic profile page.

R.J. Benzie's Articles: (21)

Composition of the amniotic fluid and maternal serum in pregnancy☆

AbstractThe following parameters in maternal serum and amniotic fluid were simultaneously estimated at varying periods of gestation by manual and automated techniques in 252 samples: bilirubin, sodium, potassium, chloride, total CO2, urea nitrogen, glucose, uric acid, creatinine, total protein, albumin, osmolality, alkaline phosphatase, acid phosphatase, lactic dehydrogenase, hydroxybutyric dehydrogenase, and creatine kinase. Analysis of the results established norms for several parameters and indicated areas of difference from results of other workers. Emphasis is placed on the need for further biochemical studies of this nature.

Amniotic fluid tests for fetal maturity☆

AbstractEighteen biochemical parameters and one cytologic test (percentage of lipid-positive cells) in amniotic fluid were assessed for their value in establishing fetal maturity. Ten parameters showed a trend with gestation but the three best tests were percentage of lipid-positive cells, lecithin/sphingomyelin ratio (L/S), and creatinine. With the use of a graph containing the mean value of the three key parameters, an estimated period of gestation was produced which was 95 per cent accurate for any individual sample. With some minor deviations the three tests and the estimated period of gestation based on the three tests continued to be accurate in abnormal pregnancy states.

Nonimmunologic hydrops fetalis☆

AbstractTwenty cases of nonimmunologic hydrops fetalis were reviewed. The incidence of nonimmunologic hydrops fetalis was 12,029 (20 cases in 40,588 deliveries). The diverse etiologies of nonimmunologic hydrops fetalis are demonstrated. The incidence of erythroblastosis fetalis caused by Rh isoimmunization declined markedly. The perinatal mortality rate was 1418 or 78%. Prematurity, the presence of congenital anomalies, and the severity of hydrops fetalis contribute to this poor prognosis. However, a better understanding of the pathophysiology of hydrops fetalis, along with early detection by ultrasonography, preterm delivery with the liberal use of cesarean section, and availability of high-risk perinatal units, may enable us to improve the prognosis. A precise diagnosis should be attempted by careful antenatal and postnatal evaluation, so that accurate genetic counseling can be offered.

Genetic amniocentesis in seventy twin pregnancies☆

AbstractGenetic amniocenteses were performed in 70 twin pregnancies over an 11-year period. Both sacs were successfully sampled in 49 of 62 patients (79%). The success rate was decreased (68%) with two placentas (anterior and posterior) and was improved with gestational age ≥17 weeks (88%) and with ultrasound visualization of the septum (86%). Of three spontaneous abortions, two were attributed to amniocentesis (chorioamnionitis). When twin pregnancy is diagnosed in a patient with an indication for genetic amniocentesis, a careful reevaluation and discussion of risk factors with the couple are recommended.

Composition of the amniotic fluid and maternal serum in pregnancy☆

AbstractThe following parameters in maternal serum and amniotic fluid were simultaneously estimated at varying periods of gestation by manual and automated techniques in 252 samples: bilirubin, sodium, potassium, chloride, total CO2, urea nitrogen, glucose, uric acid, creatinine, total protein, albumin, osmolality, alkaline phosphatase, acid phosphatase, lactic dehydrogenase, hydroxybutyric dehydrogenase, and creatine kinase. Analysis of the results established norms for several parameters and indicated areas of difference from results of other workers. Emphasis is placed on the need for further biochemical studies of this nature.

Amniotic fluid tests for fetal maturity☆

AbstractEighteen biochemical parameters and one cytologic test (percentage of lipid-positive cells) in amniotic fluid were assessed for their value in establishing fetal maturity. Ten parameters showed a trend with gestation but the three best tests were percentage of lipid-positive cells, lecithin/sphingomyelin ratio (L/S), and creatinine. With the use of a graph containing the mean value of the three key parameters, an estimated period of gestation was produced which was 95 per cent accurate for any individual sample. With some minor deviations the three tests and the estimated period of gestation based on the three tests continued to be accurate in abnormal pregnancy states.

Nonimmunologic hydrops fetalis☆

AbstractTwenty cases of nonimmunologic hydrops fetalis were reviewed. The incidence of nonimmunologic hydrops fetalis was 12,029 (20 cases in 40,588 deliveries). The diverse etiologies of nonimmunologic hydrops fetalis are demonstrated. The incidence of erythroblastosis fetalis caused by Rh isoimmunization declined markedly. The perinatal mortality rate was 1418 or 78%. Prematurity, the presence of congenital anomalies, and the severity of hydrops fetalis contribute to this poor prognosis. However, a better understanding of the pathophysiology of hydrops fetalis, along with early detection by ultrasonography, preterm delivery with the liberal use of cesarean section, and availability of high-risk perinatal units, may enable us to improve the prognosis. A precise diagnosis should be attempted by careful antenatal and postnatal evaluation, so that accurate genetic counseling can be offered.

Genetic amniocentesis in seventy twin pregnancies☆

AbstractGenetic amniocenteses were performed in 70 twin pregnancies over an 11-year period. Both sacs were successfully sampled in 49 of 62 patients (79%). The success rate was decreased (68%) with two placentas (anterior and posterior) and was improved with gestational age ≥17 weeks (88%) and with ultrasound visualization of the septum (86%). Of three spontaneous abortions, two were attributed to amniocentesis (chorioamnionitis). When twin pregnancy is diagnosed in a patient with an indication for genetic amniocentesis, a careful reevaluation and discussion of risk factors with the couple are recommended.

Composition of the amniotic fluid and maternal serum in pregnancy☆

AbstractThe following parameters in maternal serum and amniotic fluid were simultaneously estimated at varying periods of gestation by manual and automated techniques in 252 samples: bilirubin, sodium, potassium, chloride, total CO2, urea nitrogen, glucose, uric acid, creatinine, total protein, albumin, osmolality, alkaline phosphatase, acid phosphatase, lactic dehydrogenase, hydroxybutyric dehydrogenase, and creatine kinase. Analysis of the results established norms for several parameters and indicated areas of difference from results of other workers. Emphasis is placed on the need for further biochemical studies of this nature.

Amniotic fluid tests for fetal maturity☆

AbstractEighteen biochemical parameters and one cytologic test (percentage of lipid-positive cells) in amniotic fluid were assessed for their value in establishing fetal maturity. Ten parameters showed a trend with gestation but the three best tests were percentage of lipid-positive cells, lecithin/sphingomyelin ratio (L/S), and creatinine. With the use of a graph containing the mean value of the three key parameters, an estimated period of gestation was produced which was 95 per cent accurate for any individual sample. With some minor deviations the three tests and the estimated period of gestation based on the three tests continued to be accurate in abnormal pregnancy states.

Nonimmunologic hydrops fetalis☆

AbstractTwenty cases of nonimmunologic hydrops fetalis were reviewed. The incidence of nonimmunologic hydrops fetalis was 12,029 (20 cases in 40,588 deliveries). The diverse etiologies of nonimmunologic hydrops fetalis are demonstrated. The incidence of erythroblastosis fetalis caused by Rh isoimmunization declined markedly. The perinatal mortality rate was 1418 or 78%. Prematurity, the presence of congenital anomalies, and the severity of hydrops fetalis contribute to this poor prognosis. However, a better understanding of the pathophysiology of hydrops fetalis, along with early detection by ultrasonography, preterm delivery with the liberal use of cesarean section, and availability of high-risk perinatal units, may enable us to improve the prognosis. A precise diagnosis should be attempted by careful antenatal and postnatal evaluation, so that accurate genetic counseling can be offered.

Genetic amniocentesis in seventy twin pregnancies☆

AbstractGenetic amniocenteses were performed in 70 twin pregnancies over an 11-year period. Both sacs were successfully sampled in 49 of 62 patients (79%). The success rate was decreased (68%) with two placentas (anterior and posterior) and was improved with gestational age ≥17 weeks (88%) and with ultrasound visualization of the septum (86%). Of three spontaneous abortions, two were attributed to amniocentesis (chorioamnionitis). When twin pregnancy is diagnosed in a patient with an indication for genetic amniocentesis, a careful reevaluation and discussion of risk factors with the couple are recommended.

Composition of the amniotic fluid and maternal serum in pregnancy☆

AbstractThe following parameters in maternal serum and amniotic fluid were simultaneously estimated at varying periods of gestation by manual and automated techniques in 252 samples: bilirubin, sodium, potassium, chloride, total CO2, urea nitrogen, glucose, uric acid, creatinine, total protein, albumin, osmolality, alkaline phosphatase, acid phosphatase, lactic dehydrogenase, hydroxybutyric dehydrogenase, and creatine kinase. Analysis of the results established norms for several parameters and indicated areas of difference from results of other workers. Emphasis is placed on the need for further biochemical studies of this nature.

Amniotic fluid tests for fetal maturity☆

AbstractEighteen biochemical parameters and one cytologic test (percentage of lipid-positive cells) in amniotic fluid were assessed for their value in establishing fetal maturity. Ten parameters showed a trend with gestation but the three best tests were percentage of lipid-positive cells, lecithin/sphingomyelin ratio (L/S), and creatinine. With the use of a graph containing the mean value of the three key parameters, an estimated period of gestation was produced which was 95 per cent accurate for any individual sample. With some minor deviations the three tests and the estimated period of gestation based on the three tests continued to be accurate in abnormal pregnancy states.

Nonimmunologic hydrops fetalis☆

AbstractTwenty cases of nonimmunologic hydrops fetalis were reviewed. The incidence of nonimmunologic hydrops fetalis was 12,029 (20 cases in 40,588 deliveries). The diverse etiologies of nonimmunologic hydrops fetalis are demonstrated. The incidence of erythroblastosis fetalis caused by Rh isoimmunization declined markedly. The perinatal mortality rate was 1418 or 78%. Prematurity, the presence of congenital anomalies, and the severity of hydrops fetalis contribute to this poor prognosis. However, a better understanding of the pathophysiology of hydrops fetalis, along with early detection by ultrasonography, preterm delivery with the liberal use of cesarean section, and availability of high-risk perinatal units, may enable us to improve the prognosis. A precise diagnosis should be attempted by careful antenatal and postnatal evaluation, so that accurate genetic counseling can be offered.

Genetic amniocentesis in seventy twin pregnancies☆

AbstractGenetic amniocenteses were performed in 70 twin pregnancies over an 11-year period. Both sacs were successfully sampled in 49 of 62 patients (79%). The success rate was decreased (68%) with two placentas (anterior and posterior) and was improved with gestational age ≥17 weeks (88%) and with ultrasound visualization of the septum (86%). Of three spontaneous abortions, two were attributed to amniocentesis (chorioamnionitis). When twin pregnancy is diagnosed in a patient with an indication for genetic amniocentesis, a careful reevaluation and discussion of risk factors with the couple are recommended.

Composition of the amniotic fluid and maternal serum in pregnancy☆

AbstractThe following parameters in maternal serum and amniotic fluid were simultaneously estimated at varying periods of gestation by manual and automated techniques in 252 samples: bilirubin, sodium, potassium, chloride, total CO2, urea nitrogen, glucose, uric acid, creatinine, total protein, albumin, osmolality, alkaline phosphatase, acid phosphatase, lactic dehydrogenase, hydroxybutyric dehydrogenase, and creatine kinase. Analysis of the results established norms for several parameters and indicated areas of difference from results of other workers. Emphasis is placed on the need for further biochemical studies of this nature.

Amniotic fluid tests for fetal maturity☆

AbstractEighteen biochemical parameters and one cytologic test (percentage of lipid-positive cells) in amniotic fluid were assessed for their value in establishing fetal maturity. Ten parameters showed a trend with gestation but the three best tests were percentage of lipid-positive cells, lecithin/sphingomyelin ratio (L/S), and creatinine. With the use of a graph containing the mean value of the three key parameters, an estimated period of gestation was produced which was 95 per cent accurate for any individual sample. With some minor deviations the three tests and the estimated period of gestation based on the three tests continued to be accurate in abnormal pregnancy states.

Nonimmunologic hydrops fetalis☆

AbstractTwenty cases of nonimmunologic hydrops fetalis were reviewed. The incidence of nonimmunologic hydrops fetalis was 12,029 (20 cases in 40,588 deliveries). The diverse etiologies of nonimmunologic hydrops fetalis are demonstrated. The incidence of erythroblastosis fetalis caused by Rh isoimmunization declined markedly. The perinatal mortality rate was 1418 or 78%. Prematurity, the presence of congenital anomalies, and the severity of hydrops fetalis contribute to this poor prognosis. However, a better understanding of the pathophysiology of hydrops fetalis, along with early detection by ultrasonography, preterm delivery with the liberal use of cesarean section, and availability of high-risk perinatal units, may enable us to improve the prognosis. A precise diagnosis should be attempted by careful antenatal and postnatal evaluation, so that accurate genetic counseling can be offered.

Genetic amniocentesis in seventy twin pregnancies☆

AbstractGenetic amniocenteses were performed in 70 twin pregnancies over an 11-year period. Both sacs were successfully sampled in 49 of 62 patients (79%). The success rate was decreased (68%) with two placentas (anterior and posterior) and was improved with gestational age ≥17 weeks (88%) and with ultrasound visualization of the septum (86%). Of three spontaneous abortions, two were attributed to amniocentesis (chorioamnionitis). When twin pregnancy is diagnosed in a patient with an indication for genetic amniocentesis, a careful reevaluation and discussion of risk factors with the couple are recommended.

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