Original articleEarly pregnancyIncreased endometrial placenta growth factor (PLGF) gene expression in women with successful implantation
Review articleOpen access
Abstract:

ObjectiveTo analyze the vascularization of the endometrium via hysteroscopy and to assess its correlation with angiogenic factor gene expression and embryo implantation rate.DesignCross-sectional study.SettingPublic university hospital.Patient(s)Patients undergoing hysteroscopy for supposed infertility.Intervention(s)Endometrial quality assessment according to Sakumoto-Masamoto, performed in the early secretory phase of the cycle. Collection of an endometrial tissue biopsy.Main Outcome Measure(s)RNA extraction, reverse transcription, and determination of gene expression of angiogenesis- and implantation-relevant factors using quantitative polymerase chain reaction. Retrieval of pregnancy information from the medical records.Result(s)Good quantity/quality RNA with infertility history was obtained from 63 participating women. Those with a “good” endometrium and subsequent pregnancy showed increased gene expression for placenta growth factor when compared with patients with a “bad” endometrium and who did not succeed with pregnancy to date. Nonpregnant women with a “good” endometrium presented an intermediate result. No significant differences were observed for several other genes tested, but trends in the same direction were observed.Conclusion(s)This study demonstrates for the first time that endometrial PLGF expression corresponds to the hysteroscopic appearance of the endometrium, and therefore has potential as a clinically relevant prognosticator for infertility treatment success.

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