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The first potassium channel toxin from the venom of the Iranian scorpion Odonthobuthus doriae

Yousra Abdel-Mottaleb - No affiliation found

2006/11/13 Short communication DOI: 10.1016/j.febslet.2006.10.029 Journal: FEBS Letters

Abstract:

AbstractThe very first member of K+ channels toxins from the venom of the Iranian scorpion Odonthobuthus doriae (OdK1) was purified, sequenced and characterized physiologically.OdK1 has 29 amino acids, six conserved cysteines and a pI value of 4.95. Based on multiple sequence alignments, OdK1 was classified as α-KTx 8.5. The pharmacological effects of OdK1 were studied on six different cloned K+ channels (vertebrate Kv1.1-Kv1.5 and Shaker IR) expressed in Xenopus laevis oocytes. Interestingly, OdK1 selectively inhibited the currents through Kv1.2 channels with an IC50 value of 183 ± 3 nM but did not affect any of the other channels.