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Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia1

Yutaka Suzuki - No affiliation found

2002/06/19 Full-length article DOI: 10.1016/S0014-5793(02)02824-7 Journal: FEBS Letters

Abstract:

AbstractThe gene encoding a transmembrane glycoprotein LIG-1, of which the extracellular region was organized with the leucine-rich repeats and immunoglobulin-like domains, was disrupted in mice by gene targeting. LIG-1-deficient mice developed a skin change on the tail and facial area after birth. The affected skin was histologically reminiscent of the epidermis in human common skin disease ‘psoriasis’. LIG-1 was expressed in basal cells of the epidermis and outer root sheath cells of hair follicles in mice. Interestingly, the LIG-1 expression was apparently down-regulated in the psoriatic lesions, suggesting that LIG-1 inversely correlates with proliferative ability of epidermal keratinocytes.