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HIF-dependent and reversible nucleosome disassembly in hypoxia-inducible gene promoters

Norio Suzuki - No affiliation found

2018/05/15 Full-length article DOI: 10.1016/j.yexcr.2018.03.020 Journal: Experimental Cell Research

Abstract:

Highlights•Nucleosome-free regions (NFRs) are established in some gene promoters in a hypoxia-dependent manner.•Hypoxia-inducible NFR (iNFR) formation requires hypoxia-inducible transcription factor (HIF) activity.•Reoxygenation induces the reassembly of nucleosome structures in iNFRs.•Nucleosome reassembly in iNFRs requires SIN3A.