HIF-dependent and reversible nucleosome disassembly in hypoxia-inducible gene promoters
Review articleOpen access
Abstract:

Highlights•Nucleosome-free regions (NFRs) are established in some gene promoters in a hypoxia-dependent manner.•Hypoxia-inducible NFR (iNFR) formation requires hypoxia-inducible transcription factor (HIF) activity.•Reoxygenation induces the reassembly of nucleosome structures in iNFRs.•Nucleosome reassembly in iNFRs requires SIN3A.

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