Effect of Transferring Parvovirus-Infected Fertilized Pig Eggs into Seronegative Gilts
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Abstract:

SUMMARYFertilized eggs were collected from four oestrus-synchronized donor gilts 32 h after presumed ovulation and were cultured for 21 h in a synthetic culture medium containing porcine parvovirus (PPV). They were then washed and transferred into four seronegative recipient gilts. Eight days later the recipient gilts were killed. Blastocysts were recovered from three of the four recipients but many of them were dead, and those which were still alive were smaller than normal. Examination of the blastocysts by the direct fluorescent antibody technique (FAT) revealed a small number of infected cells, but retardation and death of the blastocysts could not with confidence be ascribed to this infection. All four recipient gilts seroconverted following insertion of the infected eggs, and virus was detected by FAT in their uterine lymph nodes at slaughter. Histopathological changes were seen in their reproductive tracts; in particular there were inflammatory foci in the ovaries, and a marked degeneration and exfoliation of the uterine epithelium. Although PPV was not demonstrated in sloughed epithelial debris it is nevertheless considered that the uterine damage was a direct result of PPV infection. It is also probable that retardation and death of the blastocysts was a consequence of this uterine damage rather than the direct effect of virus infection.

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