Regular ArticleIn Vitro Antioxidant Activity of Calcium Antagonists against LDL Oxidation Compared with α-Tocopherol
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AbstractThe dose-dependent (1, 5, 10, 50 μM) antioxidative activity of calcium antagonists (verapamil, diltiazem, nifedipine, amlodipine, isradipine or lacidipine) and α-tocopherol against copper-induced LDL (0.25 mg/ml) oxidation was compared by measuring the diene formation and the content of TBARS. For diltiazem no antioxidant effect could be found, whereas the other calcium antagonists and α-tocopherol have demonstrated antioxidant activity at least at concentrations of 10 and 50 μM: α-tocopherol > lacidipine > nifedipine > isradipine, verapamil, amlodipine. Additionally, α-tocopherol and lacidipine were able to attenuate LDL-oxidation significantly at 1 and 5 μM These results indicate in vitro antioxidative activity of calcium antagonists especially from the dihydropyridine-type with greatest activity for the strongly lipophilic lacidipine. This might be one possible antiatherogenic mechanism of calcium antagonists, since oxidative modification enhances the atherogenic potential of LDL.

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