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Pyridinoline fluorescence in cyanogen bromide peptides of collagen

Osamu Tsuchikura - No affiliation found

1981/10/30 Full-length article DOI: 10.1016/S0006-291X(81)80139-8 Journal: Biochemical and Biophysical Research Communications

Abstract:

SummaryPyridinoline is a fluorescent crosslinking amino acid of collagen fibers. But recently some investigators claimed that it is not a crosslink component but an artefact produced by the interaction of collagen and non-collagenous contaminants during acid hydrolysis. Their claim was based on the absence of pyridinoline in cyanogen bromide peptides of collagen. However, pyridinoline fluorescence was observed in cyanogen bromide peptides from both insoluble and pepsin solubilized collagen. By these results, pyridinoline is cleared of the suspicion that it is an artefact produced during acid hydrolysis.