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Protein recycling is a major component of post-irradiation recovery in Deinococcus radiodurans strain R1

Bhakti Joshi - No affiliation found

2004/08/06 Full-length article DOI: 10.1016/j.bbrc.2004.06.062 Journal: Biochemical and Biophysical Research Communications

Abstract:

AbstractExposure to 6 kGy dose of 60Co γ-rays resulted in immediate growth arrest, followed by complete recovery of Deinococcus radiodurans strain R1 cells. Selective degradation and resynthesis of several predicted highly expressed proteins (including major chaperones, key TCA cycle enzymes, and few stress proteins) and several hypothetical proteins marked the lag period, preceding resumption of growth. A major exercise in protein recycling appears to be an integral component of post-irradiation recovery in D. radiodurans and complements the extensive DNA repair, characteristic of this extremely radioresistant bacterium.