Combination of yeast-based in vitro screens with high-performance thin-layer chromatography as a novel tool for the detection of hormonal and dioxin-like compounds
Review articleOpen access
Abstract:

Highlights•Development of planar screening tools for androgenicity, thyroidogenicity, dioxin-like effects, effects on receptors for vitamin D and retinoic acid.•Comparative evaluation of performance characteristics of the bioassays in HPTLC- and 96-well plate format.•Proof of concept with wastewater samples by the analysis of activity profiles before and after wastewater treatment.•Elimination efficiency of androgenic activity from municipal wastewater by a wastewater treatment plant was between 99.4 and 100%.

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