Original communicationA study of ovaries following preoperative administration of an extract of pregnancy urine☆
Review articleOpen access

Abstract 1.1. A study of ovarian tissue from twenty-four patients following preoperative administration of APL/PU is detailed.2.2. Primordial follicles are not affected apparently by such administrations.3.3. Degenerative changes apparently resulting from follicle stimulation are described.4.4. The end-result of these changes appears in many instances to be follicular cysts, with active granulosa and fairly well preserved ova, and surrounded by a proliferated theca interna with prominent theca lutein cells (theca-lutein cysts) and with increased thecal vascularization.5.5. Some evidence is adduced that persistency of preformed corpora lutea may result from such administrations.6.6. Attention is called to the apparent difference in response in the ovaries of the younger and older patients with hyperplasia of the endometrium.7.7. In general, it is believed that ovulation is not induced by such administrations.8.8. The possible action of these extracts in many respects is more typical of the gestational cycle than the menstrual cycle.9.9. One should probably expect no material qualitative or quantitative difference in the changes in these ovaries from those of ovaries in pregnancy.10.10. One is led to question seriously the clinical value of such action on the ovaries of the nonpregnant woman.11.11. Such changes as described are probably temporary in nature and it may be that no permanent damage results.

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