Short communicationStrain differences in tolerance induction to human γ-globulin subclasses: Dependence on macrophages☆
Review articleOpen access

AbstractBALB/c and DBA/2 mice differ with respect to ease of tolerance induction with HGG, BALB/c mice being the resistant strain. When tested for susceptibility to tolerance induction with individual IgG subclasses, both strains were easily rendered unresponsive with IgG1 and IgG2 and less so with IgG4. A strain difference appeared with IgG3, where only BALB/c mice showed complete resistance to tolerance induction. Mixtures of the IgG subclasses Showed that IgG1 and IgG2 accounted for most of the tolerance to whole HGG seen in both strains, while addition of IgG3 to the mixture made DBA/2 completely tolerant but reversed the trend toward tolerance in the BALB/c mice. By rosette assay it was found that BALB/c macrophages had receptors for IgG3 (and to a lesser extent for IgG4). These results are consistent with the hypothesis that resistance to tolerance induction with HGG is dependent on the presence of a receptor on the macrophage for a minor IgG subclass.

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