The amniotic band disruption complex. The pathogenesis of congenital limb ring-constrictions; an experimental study in the foetal rat
Review articleOpen access

AbstractThis paper reports the findings of an experimental foetal rat study which has shown that it is possible to produce mild, moderate and severe limb ring-constrictions by simulating the ligature effect of amniotic bands. Of the 40 experimental foetuses, 36 (90%) survived thein utero surgery and are included in the present study. Of these 36 foetuses, limb constriction rings were produced in 35 (97%), and anin utero limb amputation in one (3%).

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