The amniotic band disruption complex. The pathogenesis of congenital limb ring-constrictions; an experimental study in the foetal rat
Review articleOpen access
Abstract:

AbstractThis paper reports the findings of an experimental foetal rat study which has shown that it is possible to produce mild, moderate and severe limb ring-constrictions by simulating the ligature effect of amniotic bands. Of the 40 experimental foetuses, 36 (90%) survived thein utero surgery and are included in the present study. Of these 36 foetuses, limb constriction rings were produced in 35 (97%), and anin utero limb amputation in one (3%).

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