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Characterization of neuropeptide Y (NPY) receptors in human hippocampus

Wei Li - No affiliation found

1991/07/05 Short communication DOI: 10.1016/0006-8993(91)90246-R Journal: Brain Research

Abstract:

AbstractWe identified a 50 kDa neuropeptide Y (NPY) receptor from human hippocampus by affinity labeling. NPY specific binding and labeling of the receptor were inhibited in parallel by increasing concentrations of unlabeled NPY (IC= 0.27nM and0.18nM, respectively). Peptide YY (PYY), but none of the pancreatic polypeptides, was as effective as NPY in displacing [125I]NPY. NPY fragments inhibited binding with the rank order of potency: NPY>NPY13–36 >NPY20–36≥NPY18–36 >NPY1–36free acid≥NPY26–36. These results demonstrate that the human hippocampal NPY receptor is a 50 kDa protein fitting the classification of a Y2 receptor subtype.