Chapter 9 - Mesoporous Silica-Based Nano Drug-Delivery System Synthesis, Characterization, and Applications
Review articleOpen access
2019/01/01 Chapter DOI: 10.1016/B978-0-12-814033-8.00009-6
AbstractNanostructures have always been a fascinating drug delivery vehicle for addressing bioavailability, targeted delivery and enhancement of therapeutic potential of drugs. Recent developments have provided a strong scientific rationale for considering mesoporous silica nanoparticles as highly efficient drug delivery carriers. This chapter provides the most comprehensive detail on latest fabrication strategies of both ordered and hollow/rattle type mesoporous silica. Further the critical factors for efficient synthesis are discussed. Similarly, important parameters like size, surface properties, shape and structure playing a critical role in the biocompatibility are taken into account and the toxicological implications are also reviewed. Functionalization strategies for enhancement of drug loading and triggered release are elaborated. Biotechnological and biomedical applications of mesoporous silica nanostructures in treatment and management of cancer, bacterial and fungal pathogenesis, viral infections are summarized in addition to their applications in catalysis, food industries and sensors. Additionally the technology transfer, recent intellectual property rights related to mesoporous silica are also included along with the scope for future investigations on intra-cellular sustained release of drugs, genes and other therapeutic agents.
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