Long-lasting potentiation of the dentate gyrus population spike by norepinephrine
Review articleOpen access
Abstract:

AbstractThe effects of iontophoretically applied norepinephrine (NE) on the dentate gyrus field potential evoked by perforant path stimulation were examined. NE potentiated the population spike by 20–400%, whereas the population EPSP was rarely increased. At 39% of the potentiated sites NE application resulted in long-lasting potentiation (LLP) suggesting a role for NE in long-term hippocampal plasticity.

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