Subchapter 30C - Bradykinin
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Abstract:

AbstractKinins [bradykinin (BK) and [Lys0]-BK] are the active peptides for the kallikrein-kinin system (KKS) and they are potent endothelium-dependent vasodilators that contribute to vasodilation and hypotension in the systemic circulation. Kinins induce thirst in mammals but inhibit drinking in teleosts. Kinins contract non-vascular smooth muscle in the bronchus and gut, increase vascular permeability, and are involved pain perception. In kidney, kinins induce natriuresis and diuresis, which lead to decrease in blood pressure. Kinins induce inflammatory responses via inducible B1 and constitutive B2 receptors in injured tissues. Kinins are paracrine hormones as they are rapidly degraded by various enzymes. Angiotensin converting enzyme (ACE), also known as kininase II, possesses a high affinity for BK for degradation. The hypotensive effect of ACE inhibition is partly due to the delayed degradation of BK.

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