Chapter 37 - Irisin
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AbstractIrisin is one of the most recently discovered and isolated hormones, derived from mouse skeletal muscle in 2012. Irisin is secreted from muscles in response to exercise and may mediate some beneficial effects of exercise in humans, such as weight loss and thermoregulation. Irisin consists of 112 aa residues. Irisin is a cleavage protein of fibronectin type III domain 5 (FNDC5). Mouse, rat, and human irisin are 100% identical; the rates of similarity are 85% for insulin, 90% for glucagon, and 83% for leptin. Irisin is expected to be a potential therapeutic agent for the treatment of obesity and its related conditions. FNDC5 converts to irisin after exercise. An increase of irisin causes the browning of human and mouse white adipose tissues.

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