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NoteIrrelevance of growth phase with respect to the Bay n 7133 and ICI 153,066 susceptibilities of Candida albicans

William H. Beggs - No affiliation found

1986/01/01 Short communication DOI: 10.1016/0732-8893(86)90061-1 Journal: Diagnostic Microbiology and Infectious Disease

Abstract:

AbstractMiconazole at 10−5–10−4 M can kill Candidaalbicans in the logarithmic phase, but ketoconazole, the only established oral antifungal azole, cannot. Lethal potential in relation to growth phase was studied with Bay n 7133 and ICI 153,066, two recently developed oral triazoles. Each was strictly fungistatic regardless of phase of growth and was almost identical in effect to ketoconazole.