Increased synthesis of a low molecular weight protein in vincristine-resistant cells
Review articleOpen access

AbstractA 19,000-dalton peptide (pI = 5.7) that is synthesized in increased amounts in vincristine-resistant Chinese hamster cells (DC-3FVCRd-5) has been identified by two-dimensional gel electrophoresis. Reduced amounts of the protein were present in a revertant line of DC-3FVCRd-5, and only trace amounts were detected in control DC-3F cells. A similar protein (Mr = 19,000; pI = 5.7) was also found in a vincristine-resistant mouse line. Two vincristine-resistant human neuroblastoma cell lines likewise contained elevated levels of a low molecular weight acidic protein. Increased biosynthesis of the 19,000-dalton polypeptide in DC-3FVCRd-5 cells coincides with the presence of a homogeneously staining region, HSR, on a metaphase chromosome.

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