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Only one type of benzo(a)pyrene-DNA adduct is detected in transformable mouse cells

Ko-yu Lo - No affiliation found

1981/04/15 Full-length article DOI: 10.1016/0006-291X(81)91238-9 Journal: Biochemical and Biophysical Research Communications

Abstract:

AbstractWhen highly transformable BALB3T3-A31 clone 1–13 cells are exposed to benzo(a)pyrene for various lengths of time, only one type of carcinogen-DNA adduct is detected. No minor adducts were found as reported in other cell systems. High pressure liquid chromatography identified this persistent adduct as 10-trans-7R-benzo(a)pyrene diolepoxide I-deoxyguanosine. Formation of benzo(a)pyrene-deoxyguanosine adduct, therefore, appears sufficient to initiate the transformation process induced by benzo(a)pyrene in 1–13 cells.