Molecular structure of fibrinogen I. Helical content and the role of the tyrosine moiety in the fibrinogen molecule
Review articleOpen access

Abstract1.1. The helical content of fibrinogen has been calculated from ultraviolet spectroscopy and appears to agree with values found by optical rotatory dispersion.2.2. The tyrosyl titration curve of fibrinogen has been reinvestigated and is time-dependent, thus indicating that the tyrosyl groups in the molecule are not all equivalent.3.3. A correlation of the helical content and availability of the tyrosyl moiety with time suggests that the tyrosyl group in the fibrinogen molecule may play a role in the retention of helical structure.

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